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dc.creatorLuna Varo, Rosa Maríaes
dc.creatorGarcía Rondón, Anaes
dc.creatorPérez Calero, Carmenes
dc.creatorSalas Armenteros, Irenees
dc.creatorAguilera López, Andréses
dc.date.accessioned2020-06-25T16:10:32Z
dc.date.available2020-06-25T16:10:32Z
dc.date.issued2019
dc.identifier.citationLuna Varo, R.M., García Rondón, A., Pérez Calero, C., Salas Armenteros, I. y Aguilera López, A. (2019). The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops. Cold Spring Harbor Symposia on Quantitative Biology, 039594.
dc.identifier.issn0091-7451es
dc.identifier.issn1943-4456es
dc.identifier.urihttps://hdl.handle.net/11441/98270
dc.description.abstractDifferent proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and RNA export. If these processes are not properly controlled, the nascent RNA can thread back and hybridize to the DNA template forming R-loops capable of stalling replication, leading to DNA breaks. Given the transcriptional promiscuity of the genome, which leads to large amounts of RNAs from mRNAs to different types of ncRNAs, these can become a major threat to genome integrity if they form R-loops. Consequently, cells have evolved nuclear factors to prevent this phenomenon that includes THO, a conserved eukaryotic complex acting in transcription elongation and RNA processing and export that upon inactivation causes genome instability linked to R-loop accumulation. We revise and discuss here the biological relevance of THO and a number of RNA helicases, including the THO partner UAP56/DDX39B, as a paradigm of the cellular mechanisms of cotranscriptional R-loop prevention.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherCold Spring Harbor Laboratory Presses
dc.relation.ispartofCold Spring Harbor Symposia on Quantitative Biology, 039594.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleThe THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loopses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Genéticaes
dc.relation.publisherversionhttps://doi.org/10.1101/sqb.2019.84.039594es
dc.identifier.doi10.1101/sqb.2019.84.039594es
dc.journaltitleCold Spring Harbor Symposia on Quantitative Biologyes
dc.publication.initialPage039594es

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