Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers

Coste, G.; Horlacher, T.; Molina Sanz, Lidia; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Robina Ramírez, Inmaculada; Seeberger, P.H.; Gerber-Lemaire, S.

doi:10.1055/s-0030-1260033

Artículo

dc.creator	Coste, G.	es
dc.creator	Horlacher, T.	es
dc.creator	Molina Sanz, Lidia	es
dc.creator	Moreno Vargas, Antonio José	es
dc.creator	Carmona Asenjo, Ana Teresa	es
dc.creator	Robina Ramírez, Inmaculada	es
dc.creator	Seeberger, P.H.	es
dc.creator	Gerber-Lemaire, S.	es
dc.date.accessioned	2020-06-03T09:22:05Z
dc.date.available	2020-06-03T09:22:05Z
dc.date.issued	2011
dc.identifier.citation	Coste, G., Horlacher, T., Molina Sanz, L., Moreno Vargas, A.J., Carmona Asenjo, A.T., Robina Ramírez, I.,...,Gerber-Lemaire, S. (2011). Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers. Synthesis, 11, 1759-1770.
dc.identifier.issn	0039-7881 (impreso)	es
dc.identifier.issn	1437-210X (electrónico)	es
dc.identifier.uri	https://hdl.handle.net/11441/97381
dc.description.abstract	Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues based on furylcarbopeptoid skeletons is described. Potent and selective ligands for bacterial 16S rRNA were identified using microarray techniques by determining the affinity of these derivatives toward bacterial and human ribosomal RNAs	es
dc.format	application/pdf	es
dc.format.extent	12 p.	es
dc.language.iso	eng	es
dc.publisher	Thieme Publishing; Georg Thieme Verlag	es
dc.relation.ispartof	Synthesis, 11, 1759-1770.
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Antibiotics	es
dc.subject	2-deoxystreptamine dimers	es
dc.subject	Microarray	es
dc.subject	Ribosomal RNA	es
dc.subject	Solid-phase synthesis	es
dc.title	Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers	es
dc.type	info:eu-repo/semantics/article	es
dcterms.identifier	https://ror.org/03yxnpp24
dc.type.version	info:eu-repo/semantics/publishedVersion	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.contributor.affiliation	Universidad de Sevilla. Departamento de Química orgánica	es
dc.relation.publisherversion	http://dx.doi.org/10.1055/s-0030-1260033	es
dc.identifier.doi	10.1055/s-0030-1260033	es
dc.journaltitle	Synthesis	es
dc.publication.issue	11	es
dc.publication.initialPage	1759	es
dc.publication.endPage	1770	es

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