dc.creator | Coste, G. | es |
dc.creator | Horlacher, T. | es |
dc.creator | Molina Sanz, Lidia | es |
dc.creator | Moreno Vargas, Antonio José | es |
dc.creator | Carmona Asenjo, Ana Teresa | es |
dc.creator | Robina Ramírez, Inmaculada | es |
dc.creator | Seeberger, P.H. | es |
dc.creator | Gerber-Lemaire, S. | es |
dc.date.accessioned | 2020-06-03T09:22:05Z | |
dc.date.available | 2020-06-03T09:22:05Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Coste, G., Horlacher, T., Molina Sanz, L., Moreno Vargas, A.J., Carmona Asenjo, A.T., Robina Ramírez, I.,...,Gerber-Lemaire, S. (2011). Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers. Synthesis, 11, 1759-1770. | |
dc.identifier.issn | 0039-7881 (impreso) | es |
dc.identifier.issn | 1437-210X (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/97381 | |
dc.description.abstract | Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues based on furylcarbopeptoid skeletons is described. Potent and selective ligands for bacterial 16S rRNA were identified using microarray techniques by determining the affinity of these derivatives toward bacterial and human ribosomal RNAs | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | Thieme Publishing; Georg Thieme Verlag | es |
dc.relation.ispartof | Synthesis, 11, 1759-1770. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Antibiotics | es |
dc.subject | 2-deoxystreptamine dimers | es |
dc.subject | Microarray | es |
dc.subject | Ribosomal RNA | es |
dc.subject | Solid-phase synthesis | es |
dc.title | Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.publisherversion | http://dx.doi.org/10.1055/s-0030-1260033 | es |
dc.identifier.doi | 10.1055/s-0030-1260033 | es |
dc.journaltitle | Synthesis | es |
dc.publication.issue | 11 | es |
dc.publication.initialPage | 1759 | es |
dc.publication.endPage | 1770 | es |