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Artículo
Transcription-mediated replication hindrance: a major driver of genome instability
dc.creator | Gómez González, Belén | es |
dc.creator | Aguilera López, Andrés | es |
dc.date.accessioned | 2019-11-25T19:32:20Z | |
dc.date.available | 2019-11-25T19:32:20Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Gómez González, B. y Aguilera López, A. (2019). Transcription-mediated replication hindrance: a major driver of genome instability. Genes and Development, 33 (15-16), 1008-1026. | |
dc.identifier.issn | 1549-5477 | es |
dc.identifier.uri | https://hdl.handle.net/11441/90520 | |
dc.description.abstract | Genome replication involves dealing with obstacles that can result from DNA damage but also from chromatin alterations, topological stress, tightly bound proteins or non-B DNA structures such as R loops. Experimental evidence reveals that an engaged transcription machinery at the DNA can either enhance such obstacles or be an obstacle itself. Thus, transcription can become a potentially hazardous process promoting localized replication fork hindrance and stress, which would ultimately cause genome instability, a hallmark of cancer cells. Understanding the causes behind transcription–replication conflicts as well as how the cell resolves them to sustain genome integrity is the aim of this review. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Cold Spring Harbor Laboratory Press | es |
dc.relation.ispartof | Genes and Development, 33 (15-16), 1008-1026. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Transcription-mediated replication hindrance: a major driver of genome instability | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.publisherversion | http://dx.doi.org/10.1101/gad.324517.119 | es |
dc.identifier.doi | 10.1101/gad.324517.119 | es |
idus.format.extent | 18 p. | es |
dc.journaltitle | Genes and Development | es |
dc.publication.volumen | 33 | es |
dc.publication.issue | 15-16 | es |
dc.publication.initialPage | 1008 | es |
dc.publication.endPage | 1026 | es |
Ficheros | Tamaño | Formato | Ver | Descripción |
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pub1008.pdf | 1.324Mb | [PDF] | Ver/ | |