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dc.creatorMartínez de Pablos, Rocíoes
dc.creatorFernández Villarán, Ruthes
dc.creatorArgüelles Castilla, Sandroes
dc.creatorHerrera Carmona, Antonio Josées
dc.creatorVenero Recio, José Luises
dc.creatorAyala Gómez, Antonioes
dc.date.accessioned2019-02-19T08:54:55Z
dc.date.available2019-02-19T08:54:55Z
dc.date.issued2006
dc.identifier.citationMartínez de Pablos, R., Fernández Villarán, R., Argüelles Castilla, S., Herrera Carmona, A.J., Venero Recio, J.L. y Ayala Gómez, A. (2006). Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex. Journal of Neuroscience, 26 (21), 5709-5719.
dc.identifier.issn1529-2401es
dc.identifier.urihttps://hdl.handle.net/11441/83199
dc.description.abstractInflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because sensitivity to inflammation is not equal in all brain structures, a direct relationship is not clear. Our aim was to test whether some physiological circumstances, such as stress, could enhance susceptibility to inflammation in the prefrontal cortex (PFC), which shows a relative resistance to inflammation. PFC is important in many brain functions and is a target for some neurodegenerative diseases. We induced an inflammatory process by a single intracortical injection of 2 μg of lipopolysaccharide (LPS), a potent proinflammogen, in nonstressed and stressed rats. We evaluated the effect of our treatment on inflammatory markers, neuronal populations, BDNF expression, and behavior of several mitogen-activated protein (MAP) kinases and the transcription factor cAMP response element-binding protein. Stress strengthens the changes induced by LPS injection: microglial activation and proliferation with an increase in the levels of the proinflammatory cytokine tumor necrosis factor-α; loss of cells such as astroglia, seen as loss of glial fibrillary acidic protein immunoreactivity, and neurons, studied by neuronal-specific nuclear protein immunohistochemistry and GAD67 and NMDA receptor 1A mRNAs expression by in situ hybridization. A significant increase in the BDNF mRNA expression and modifications in the levels of MAP kinase phosphorylation were also found. In addition, we observed a protective effect from RU486 [mifepristone (11β-[p-(dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one)], a potent inhibitor of the glucocorticoid receptor activation. All of these data show a synergistic effect between inflammation and stress, which could explain the relationship described between stress and some neurodegenerative pathologies.es
dc.description.sponsorshipEspaña,Ministerio de Educación y Ciencia Grants SAF2002-01952 and SAF2004-06601es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherSociety for Neurosciencees
dc.relation.ispartofJournal of Neuroscience, 26 (21), 5709-5719.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectprefrontal cortexes
dc.subjectstresses
dc.subjectinflammationes
dc.subjectneuronal deathes
dc.subjectBDNFes
dc.subjectMAP kinaseses
dc.titleStress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortexes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legales
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica y Biología Moleculares
dc.relation.projectIDGrants SAF2002-01952 and SAF2004-06601es
dc.relation.publisherversionhttp://dx.doi.org//10.1523/JNEUROSCI.0802-06.2006es
dc.identifier.doidoi.org/10.1523/JNEUROSCI.0802-06.2006es
idus.format.extent10 p.es
dc.journaltitleJournal of Neurosciencees
dc.publication.volumen26es
dc.publication.issue21es
dc.publication.initialPage5709es
dc.publication.endPage5719es
dc.contributor.funderMinisterio de Educación y Ciencia (MEC). España

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional