Artículo
Dynamic Kinetic Resolution of Hetero biaryl Ketones by Zinc- Catalyzed Asymmetr ic Hydrosil ylation
Autor/es | Hornillos, Valentín
Carmona, José A. Ros Lao, Abel Iglesias Sigüenza, Francisco Javier López Serrano, Joaquín Fernández Fernández, Rosario Fátima Lassaletta, José M. |
Departamento | Universidad de Sevilla. Departamento de Química orgánica Universidad de Sevilla. Departamento de Química Inorgánica |
Fecha de publicación | 2018 |
Fecha de depósito | 2019-02-01 |
Publicado en |
|
Premios | Premio Anual Publicación Científica Destacada de la US. Facultad de Química |
Resumen | Adiastereo-
and
highly
enantioselective
dynamic
kinetic
resolution
(DKR)
of configurationally
labile
hetero-
biaryl
ketones
is described.
The
DKR
proceeds
by zinc-
catalyze
dhydrosilylation
of the ... Adiastereo- and highly enantioselective dynamic kinetic resolution (DKR) of configurationally labile hetero- biaryl ketones is described. The DKR proceeds by zinc- catalyze dhydrosilylation of the carbonyl group ,thus leading to secondary alcohols bearing axial and central chirality .The strategy relies on the labilization of the stereogenic axis that takes place thanks to aLewis acid–base interaction between anitrogen atom in the heterocycle and the ketone carbonyl group .The synthetic utility of the methodology is demonstrated through stereospecific transformations into either N,N-ligands or appealing axially chiral, bifunctional thiourea organocata- lysts. |
Identificador del proyecto | CTQ2016-76908-C2-1-P
CTQ2016-76908-C2-2-P RYC-2013-12585 2012/FQM 10787 291780 |
Cita | Hornillos, V., Carmona, J.A., Ros Lao, A., Iglesias Sigüenza, F.J., López Serrano, J., Fernández Fernández, R.F. y Lassaletta, J.M. (2018). Dynamic Kinetic Resolution of Hetero biaryl Ketones by Zinc- Catalyzed Asymmetr ic Hydrosil ylation. Angewandte Chemie International Edition, 57, 3777-3781. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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anie201713200_Hornillos.pdf | 3.009Mb | [PDF] | Ver/ | Versión post-print |