dc.creator | Muñoz Bravo, José Luis | es |
dc.creator | Flores Martínez, Álvaro | es |
dc.creator | Herrero Martín, Griselda | es |
dc.creator | Puri, Sapna | es |
dc.creator | Taketo, Makoto Mark | es |
dc.creator | Rojas González, Anabel | es |
dc.creator | Hebrok, Matthias | es |
dc.creator | Cano, David A. | es |
dc.date.accessioned | 2019-01-21T13:06:39Z | |
dc.date.available | 2019-01-21T13:06:39Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Muñoz Bravo, J.L., Flores Martínez, Á., Herrero Martín, G., Puri, S., Taketo, M.M., Rojas González, A.,...,Cano, D.A. (2016). Loss of pancreas upon activated Wnt signaling is concomitant with emergence of gastrointestinal identity. PLoS ONE, 11, 1-22. | |
dc.identifier.issn | 1932-6203 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/81779 | |
dc.description.abstract | Organ formation is achieved through the complex interplay between signaling pathways
and transcriptional cascades. The canonical Wnt signaling pathway plays multiple roles
during embryonic development including patterning, proliferation and differentiation in distinct
tissues. Previous studies have established the importance of this pathway at multiple
stages of pancreas formation as well as in postnatal organ function and homeostasis. In
mice, gain-of-function experiments have demonstrated that activation of the canonical Wnt
pathway results in pancreatic hypoplasia, a phenomenon whose underlying mechanisms
remains to be elucidated. Here, we show that ectopic activation of epithelial canonical Wnt
signaling causes aberrant induction of gastric and intestinal markers both in the pancreatic
epithelium and mesenchyme, leading to the development of gut-like features. Furthermore,
we provide evidence that β -catenin-induced impairment of pancreas formation depends on
Hedgehog signaling. Together, our data emphasize the developmental plasticity of pancreatic
progenitors and further underscore the key role of precise regulation of signaling pathways
to maintain appropriate organ boundaries. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Public Library of Science | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Loss of pancreas upon activated Wnt signaling is concomitant with emergence of gastrointestinal identity | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0164714 | es |
dc.identifier.doi | 10.1371/journal.pone.0164714 | es |
idus.format.extent | 22 p. | es |
dc.journaltitle | PLoS ONE | es |
dc.publication.volumen | 11 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 22 | es |