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Rearrangement of cell types in the rat carotid body neurogenic niche induced by chronic intermittent hypoxia
dc.creator | Caballero Eraso, Candela | es |
dc.creator | Colinas Miranda, Olalla | es |
dc.creator | González Montelongo, Rafaela | es |
dc.creator | Cabeza, Jose M. | es |
dc.creator | Gao Chen, Lin | es |
dc.creator | Pardal Redondo, Ricardo | es |
dc.creator | López Barneo, José | es |
dc.creator | Ortega Sáenz, Patricia | es |
dc.date.accessioned | 2024-09-17T13:50:51Z | |
dc.date.available | 2024-09-17T13:50:51Z | |
dc.date.issued | 2023-01-17 | |
dc.identifier.citation | Caballero Eraso, C., Colinas Miranda, O., González Montelongo, R., Cabeza, J.M., Gao Chen, L., Pardal Redondo, R.,...,Ortega Sáenz, P. (2023). Rearrangement of cell types in the rat carotid body neurogenic niche induced by chronic intermittent hypoxia. Journal of physiology-London, 601 (5), 1017-1036. https://doi.org/10.1113/JP283897. | |
dc.identifier.issn | 0022-3751 | es |
dc.identifier.issn | 1469-7793 | es |
dc.identifier.uri | https://hdl.handle.net/11441/162567 | |
dc.description.abstract | The carotid body (CB) is a prototypical acute oxygen (O2)-sensing organ that mediates reflex hyperventilation and increased cardiac output in response to hypoxaemia. CB overactivation, secondary to the repeated stimulation produced by the recurrent episodes of intermittent hypoxia, is believed to contribute to the pathogenesis of sympathetic hyperactivity present in sleep apnoea patients. Although CB functional plasticity induced by chronic intermittent hypoxia (CIH) has been demonstrated, the underlying mechanisms are not fully elucidated. Here, we show that CIH induces a small increase in CB volume and rearrangement of cell types in the CB, characterized by a mobilization of immature quiescent neuroblasts, which enter a process of differentiation into mature, O2-sensing and neuron-like, chemoreceptor glomus cells. Prospective isolation of individual cell classes has allowed us to show that maturation of CB neuroblasts is paralleled by an upregulation in the expression of specific glomus cell genes involved in acute O2-sensing. CIH enhances mitochondrial responsiveness to hypoxia in maturing neuroblasts as well as in glomus cells. These data provide novel perspectives on the pathogenesis of CB-mediated sympathetic overflow that may lead to the development of new pharmacological strategies of potential applicability in sleep apnoea patients. | es |
dc.format | application/pdf | es |
dc.format.extent | 20 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.relation.ispartof | Journal of physiology-London, 601 (5), 1017-1036. | |
dc.subject | Carotid body | es |
dc.subject | Neurogenic niche | es |
dc.subject | Neuroblasts | es |
dc.subject | Chronic intermittent hypoxia | es |
dc.subject | Sympathetic overactivation | es |
dc.subject | Sleep apnea | es |
dc.subject | Prospective cell isolation | es |
dc.subject | Oxygen sensing cells | es |
dc.title | Rearrangement of cell types in the rat carotid body neurogenic niche induced by chronic intermittent hypoxia | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.contributor.affiliation | Instituto de Biomedicina de Sevilla (IBIS) | es |
dc.relation.projectID | PI-0125-2016 | es |
dc.relation.projectID | PID2019-106410RB-I00 | es |
dc.relation.projectID | PID2019-110817R | es |
dc.relation.publisherversion | https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP283897 | es |
dc.identifier.doi | 10.1113/JP283897 | es |
dc.journaltitle | Journal of physiology-London | es |
dc.publication.volumen | 601 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 1017 | es |
dc.publication.endPage | 1036 | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Junta de Andalucía. Consejería de Salud | es |
dc.contributor.funder | Ministerio de Ciencias, Innovación y Salud. | es |
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