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dc.creatorSánchez Cid, Pabloes
dc.creatorAlonso González, Maríaes
dc.creatorJiménez-Rosado, Mercedeses
dc.creatorRafii-El-Idrissi Benhnia, Mohammedes
dc.creatorRuiz-Mateos Carmona, Ezequieles
dc.creatorOstos Marcos, Francisco Josées
dc.creatorRomero García, Albertoes
dc.creatorPérez-Puyana, Víctor Manueles
dc.date.accessioned2024-05-28T06:36:51Z
dc.date.available2024-05-28T06:36:51Z
dc.date.issued2024-04
dc.identifier.citationSánchez Cid, P., Alonso González, M., Jiménez-Rosado, M., Rafii-El-Idrissi Benhnia, M., Ruiz-Mateos Carmona, E., Ostos Marcos, F.J.,...,Pérez-Puyana, V.M. (2024). Effect of different crosslinking agents on hybrid chitosan/collagen hydrogels for potential tissue engineering applications. International Journal of Biological Macromolecules, 263, part 2 (129858). https://doi.org/10.1016/j.ijbiomac.2024.129858.
dc.identifier.issn0141-8130es
dc.identifier.issn1879-0003es
dc.identifier.urihttps://hdl.handle.net/11441/159072
dc.description.abstractTissue engineering (TE) demands scaffolds that have the necessary resistance to withstand the mechanical stresses once implanted in our body, as well as excellent biocompatibility. Hydrogels are postulated as interesting materials for this purpose, especially those made from biopolymers. In this study, the microstructure and rheological performance, as well as functional and biological properties of chitosan and collagen hydrogels (CH/CG) crosslinked with different coupling agents, both natural such as d-Fructose (F), genipin (G) and transglutaminase (T) and synthetic, using a combination of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride with N-hydroxysuccinimide (EDC/NHS) will be assessed. FTIR tests were carried out to determine if the proposed crosslinking reactions for each crosslinking agent occurred as expected, obtaining positive results in this aspect. Regarding the characterization of the properties of each system, two main trends were observed, from which it could be established that crosslinking with G and EDC-NHS turned out to be more effective and beneficial than with the other two crosslinking agents, producing significant improvements with respect to the base CH/CG hydrogel. In addition, in vitro tests demonstrated the potential application in TE of these systems, especially for those crosslinked with G, T and EDC-NHS.es
dc.description.sponsorshipCITIUS, central services of the Universidad de Sevilla (Spain)es
dc.formatapplication/pdfes
dc.format.extent12 p.es
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofInternational Journal of Biological Macromolecules, 263, part 2 (129858).
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChitosanes
dc.subjectCollagenes
dc.subjectChemical crosslinkinges
dc.subjectRheologyes
dc.subjectBiocompatibilityes
dc.subjectTissue engineeringes
dc.titleEffect of different crosslinking agents on hybrid chitosan/collagen hydrogels for potential tissue engineering applicationses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Ingeniería Químicaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunologíaes
dc.relation.projectIDPID2021-124294OB-C21es
dc.relation.projectIDPAIDI DOCTOR 2019–2020 DOC_00586es
dc.relation.projectIDPAIDI DOCTOR 2019–2020 DOC_00963es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141813024006615?via%3Dihubes
dc.identifier.doi10.1016/j.ijbiomac.2024.129858es
dc.contributor.groupUniversidad de Sevilla. TEP229: Tecnología y Diseño de Productos Multicomponenteses
dc.contributor.groupUniversidad de Sevilla. CTS590: Inmunovirología (Sistema Sanitario Público de Andalucía. Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (FISEVI))es
dc.contributor.groupUniversidad de Sevilla. FQM206: Grupo de Cinética del Profesor Rodríguez Velascoes
dc.journaltitleInternational Journal of Biological Macromoleculeses
dc.publication.volumen263, part 2es
dc.publication.issue129858es
dc.contributor.funderMinisterio de Ciencia e Innovación (MICIN). Españaes
dc.contributor.funderEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)es
dc.contributor.funderJunta de Andalucíaes
dc.contributor.funderConsejo Superior de Investigaciones Científicas (CSIC)es

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