Artículo
Silver-free gold-catalyzed heterocyclizations through intermolecular H-bonding activation.
Autor/es | Elías Rodríguez, María del Pilar
Matador Martínez, Esteban Benítez Narváez, Manuel Tejero, Tomás Díez Martín, Elena Fernández Fernández, Rosario Fátima Monge Fernández, David Lassaletta, José M. |
Departamento | Universidad de Sevilla. Departamento de Química orgánica |
Fecha de publicación | 2023-01-27 |
Fecha de depósito | 2024-05-23 |
Publicado en |
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Resumen | Modulable monosulfonyl squaramides have been shown to exert activation of gold(I) chloride complexes through H-bonding in an intermolecular way. Combinations of (PPh3)AuCl or IPrAuCl complexes and an optimal sulfonyl ... Modulable monosulfonyl squaramides have been shown to exert activation of gold(I) chloride complexes through H-bonding in an intermolecular way. Combinations of (PPh3)AuCl or IPrAuCl complexes and an optimal sulfonyl squaramidecocatalyst bearing two 3,5-bis(trifluoromethyl)phenyl groups efficiently catalyzed diverse heterocyclizations and a cyclopropanationreaction, avoiding in all cases undesired side reactions. Computational studies indicate that the Au−Cl bond breaks by transligationto the triple bond in a ternary complex formed by the actual AuCl···HBD catalyst and the substrate. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Junta de Andalucía Gobierno regional de Aragón |
Identificador del proyecto | PID2019-106358GB-C21
PID2019-106358GBC22 PID2019-104090RB-100 MSALAS-2022-19993 P18-FR-3531 P18- FR-644 US-1262867 DOC_00749 |
Cita | Elías Rodríguez, M.d.P., Matador Martínez, E., Benítez Narváez, M., Tejero, T., Díez Martín, E., Fernández Fernández, R.F.,...,Lassaletta, J.M. (2023). Silver-free gold-catalyzed heterocyclizations through intermolecular H-bonding activation.. Journal of Organic Chemistry, 88 (4), 2487-2492. https://doi.org/10.1021/acs.joc.2c02932. |
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