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dc.creatorPavillard, Luís E.es
dc.creatorCañadas-Lozano, Diegoes
dc.creatorAlcocer-Gómez, Elísabetes
dc.creatorMarín Aguilar, Fabiolaes
dc.creatorPereira, Sheilaes
dc.creatorRobertson, Avril A.B.es
dc.creatorMuntané Relat, Jordies
dc.creatorRyffel, Bernhardes
dc.creatorCooper, Matthew A.es
dc.creatorQuiles, José L.es
dc.creatorBullon, Pedroes
dc.creatorRuiz-Cabello, Jesúses
dc.creatorCordero, Mario D.es
dc.date.accessioned2024-05-07T15:25:22Z
dc.date.available2024-05-07T15:25:22Z
dc.date.issued2017-09-08
dc.identifier.issn1949-2553es
dc.identifier.urihttps://hdl.handle.net/11441/157839
dc.description.abstractThe NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction induced by high-caloric diets. In this study, we investigate the molecular mechanisms by which NLRP3 inhibition may attenuate diet-induced cardiac injury. Here we show the cardiac damage induced by high sugar diet (HSD), high fat diet (HFD) or high sugar/fat diet (HSFD) over 15 weeks. Genetic ablation of NLRP3 protected against this damage by autophagy induction and apoptotic control. Furthermore, NLRP3 inhibition by the selective small molecule MCC950 resulted in similar autophagy induction and apoptotic control in hearts after diets. These data were reproduced in THP-1 cells treated with MCC950 and cultured in media supplemented with serum from mice dosed with MCC950 and fed with diets. NLRP3 inhibition exerted beneficial metabolic, and autophagic adaptations in hearts from obesogenic diets. The inhibition of NLRP3 activation may hold promise in the treatment of metabolic and cardiovascular diseases.es
dc.formatapplication/pdfes
dc.format.extent17 p.es
dc.language.isoenges
dc.publisherImpact Journals LLCes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleNLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy inductiones
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Estomatologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.contributor.affiliationInstituto de Biomedicina de Sevilla (IBIS)
dc.relation.projectIDCTS113es
dc.relation.projectIDPI-0036-2014es
dc.relation.publisherversionhttps://www.oncotarget.com/article/20763/text/es
dc.identifier.doi10.18632/oncotarget.20763es
dc.journaltitleOncotargetes
dc.publication.volumen8es
dc.publication.issue59es
dc.publication.initialPage99740es
dc.publication.endPage99756es
dc.contributor.funderGrupo de Investigacion Junta de Andaluciaes
dc.contributor.funderConsejería de Salud Junta de Andalucíaes

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