Dataset
Study the immunotoxic effect of reduced graphene [Dataset]
Autor/es | Cebadero Domínguez, Óscar
Casas Rodríguez, Antonio Puerto Rodríguez, María Cameán Fernández, Ana María Jos Gallego, Ángeles Mencía |
Compilador de datos | Cebadero Domínguez, Óscar |
Gestor de datos | Jos Gallego, Ángeles Mencía |
Contacto | Jos Gallego, Ángeles Mencía |
Departamento | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal |
Idioma (ISO) | inglés (eng) |
Fecha de difusión | 2023-12-20 |
Fecha de depósito | 2023-12-20 |
Fecha de creación | 2022 |
Resumen | The cytotoxicity response of reduced graphene oxide (rGO) was investigated in monocytes (THP-1) and human T cells (Jurkat). A mean effective concentration (EC50-24 h) of 121.45 ± 11.39 μg/mL and 207.51 ± 21.67 μg/mL for ... The cytotoxicity response of reduced graphene oxide (rGO) was investigated in monocytes (THP-1) and human T cells (Jurkat). A mean effective concentration (EC50-24 h) of 121.45 ± 11.39 μg/mL and 207.51 ± 21.67 μg/mL for cytotoxicity was obtained in THP-1 and Jurkat cells, respectively. rGO decreased THP-1 monocytes differentiation at the highest concentration after 48 h of exposure. Regarding the inflammatory response at genetic level, changes (up and downregulations) were observed depending on the cell line, the exposure time and the interleukins investigated. Apoptosis/ necrosis genes expression was not altered in THP-1 cells but in Jurkat cells BAX and BCL-2 were downregulated after 4h. Finally, rGO did not trigger a significant release of any cytokine at any exposure time assayed. Dataset contains the numerical values of the results obtained regarding cytotoxicity, differentiation, gene expression and interleukin leakage. |
Contenido | Numerical data of the results of cytotoxicity, differentiation, gene expression and interleukin leakage |
Agencias financiadoras | Junta de Andalucía European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | US-1259106
P18-RT-1993 |
Asociado a la publicación | Cebadero-Domínguez O, Casas-Rodríguez A, Puerto M, Cameán AM, Jos A. In vitro safety assessment of reduced graphene oxide in human monocytes and T cells. Environmental Research 232 (2023) 116356. https://doi.org/10.1016/j.envres.2023.116356 |
Cita | Cebadero Domínguez, Ó., Casas Rodríguez, A.,...,Jos Gallego, Á.M. (2022). Study the immunotoxic effect of reduced graphene [Dataset]. idUS (Depósito de Investigación de la Universidad de Sevilla). https://doi.org/10.12795/11441/152721 |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Cebadero et al 23 Environ Res ... | 23.75Kb | [Microsoft Excel 2007] | Acceso restringido. Petición a través del formulario. | |
readme_Cebadero et al 23 Environ ... | 5.345Kb | [Fichero de texto] | Ver/ | Fichero readme.txt |