Dataset
Genotoxicity evaluation of graphene in vitro assays [dataset]
Autor/es | Cebadero Domínguez, Óscar
Medrano Padial, Concepción Puerto Rodríguez, María Sánchez Ballester, Soraya Cameán Fernández, Ana María Jos Gallego, Ángeles Mencía |
Compilador de datos | Cebadero Domínguez, Óscar |
Gestor de datos | Puerto Rodríguez, María |
Contacto | Puerto Rodríguez, María |
Departamento | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal |
Idioma (ISO) | inglés (eng) |
Fecha de difusión | 2023-12-20 |
Fecha de depósito | 2023-12-20 |
Fecha de creación | 2021 |
Resumen | The aim of this study was to assess the potential mutagenicity and genotoxicity of graphene oxide (GO) and reduced-graphene oxide (rGO) following the recommendations of the European Food Safety Authority (EFSA). Thus, the ... The aim of this study was to assess the potential mutagenicity and genotoxicity of graphene oxide (GO) and reduced-graphene oxide (rGO) following the recommendations of the European Food Safety Authority (EFSA). Thus, the mouse lymphoma assay (MLA) and the micronucleus test (MN) were performed in L5178YTk ± cells, and the Caco-2 cells were used for the standard and modified comet assays. The results indicated that GO (0–250 μg/mL) was not mutagenic in the MLA. However, rGO revealed mutagenic activity from 250 μg/mL and 125 μg/mL after 4h and 24h of exposure, respectively. In the MN test, negative results were obtained for both compounds at the concentrations assayed (0–250 μg/mL) for GO/rGO. Moreover, no DNA strand breaks, or oxidative DNA damage were detected in Caco-2 cells exposed to GO (0–250 μg/mL) and rGO (0–176.3 μg/mL for 24h and 0–166.5 μg/mL for 48h). Dataset contains the numerical values of the results obtained regarding to MLA assay 4 and 24 h, MN test 24h and comet assay 24 and 48h. |
Contenido | Numerical data of the results of MLA assay, MN test and comet assay |
Agencias financiadoras | Junta de Andalucía European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | US-1259106
P18-RT-1993 |
Asociado a la publicación | Cebadero-Domínguez, O.; Minguez, O.; Medrano-Padial, C.; Puerto, M.; Sánchez-Ballester, S.; Cameán, A.M.; Jos, A. Genotoxicity evaluation of graphene derivatives by a battery of in vitro assays. Chemico-Biological Interactions 372 (2023) 110367. https://doi.org.10.1016/j.cbi.2023.110367 |
Cita | Cebadero Domínguez, Ó., Medrano Padial, C.,...,Jos Gallego, Á.M.. Genotoxicity evaluation of graphene in vitro assays [dataset]. idUS (Depósito de Investigación de la Universidad de Sevilla). https://doi.org/10.12795/11441/152713 |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Cebadero et al., 2023 Chemic-Biol ... | 43.18Kb | [Microsoft Excel 2007] | Acceso restringido. Petición a través del formulario. | |
readme_Cebadero et al_2023 ... | 6.470Kb | [Fichero de texto] | Ver/ | Fichero readme.txt |