Artículo
A Lupin (Lupinus angustifolius) Protein Hydrolysate Exerts Anxiolytic-Like Effects in Western Diet-Fed ApoE−/− Mice
Autor/es | Santos-Sánchez, Guillermo
Ponce España, Eduardo ![]() ![]() ![]() ![]() López García, Juan Carlos ![]() ![]() ![]() ![]() ![]() ![]() ![]() Álvarez-Sánchez, Nuria Álvarez López, Ana Isabel ![]() ![]() ![]() Pedroche, Justo Millán-Linares, María del Carmen Lardone, Patricia Judith ![]() ![]() ![]() ![]() ![]() ![]() ![]() Bejarano, Ignacio Cruz Chamorro, Iván Carrillo Vico, Antonio ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Departamento | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología Universidad de Sevilla. Departamento de Psicología Experimental |
Fecha de publicación | 2022 |
Fecha de depósito | 2023-07-11 |
Publicado en |
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Resumen | Anxiety is the most prevalent psychiatric disorder worldwide, causing a substantial
economic burden due to the associated healthcare costs. Given that commercial anxiolytic treatments
may cause important side effects and ... Anxiety is the most prevalent psychiatric disorder worldwide, causing a substantial economic burden due to the associated healthcare costs. Given that commercial anxiolytic treatments may cause important side effects and have medical restrictions for prescription and high costs, the search for new natural and safer treatments is gaining attention. Since lupin protein hydrolysate (LPH) has been shown to be safe and exert anti-inflammatory and antioxidant effects, key risk factors for the anxiety process and memory impairment, we evaluated in this study the potential effects of LPH on anxiety and spatial memory in a Western diet (WD)-induced anxiety model in ApoE−/− mice. We showed that 20.86% of the 278 identified LPH peptides have biological activity related to anxiolytic/analgesic effects; the principal motifs found were the following: VPL, PGP, YL, and GQ. Moreover, 14 weeks of intragastrical LPH treatment (100 mg/kg) restored the WD-induced anxiety effects, reestablishing the anxiety levels observed in the standard diet (SD)-fed mice since they spent less time in the anxiety zones of the elevated plus maze (EPM). Furthermore, a significant increase in the number of head dips was recorded in LPH-treated mice, which indicates a greater exploration capacity and less fear due to lower levels of anxiety. Interestingly, the LPH group showed similar thigmotaxis, a well-established indicator of animal anxiety and fear, to the SD group, counteracting the WD effect. This is the first study to show that LPH treatment has anxiolytic effects, pointing to LPH as a potential component of future nutritional therapies in patients with anxiety. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España Consejería de Salud. Junta de Andalucía. |
Identificador del proyecto | AGL2012-40247-C02-01, AGL2012-40247-C02-02
![]() PC-0111-2016-0111, PEMP-0085-2020 ![]() |
Cita | Santos-Sánchez, G., Ponce España, E., López García, J.C., Álvarez-Sánchez, N., Álvarez López, A.I., Pedroche, J.,...,Carrillo Vico, A. (2022). A Lupin (Lupinus angustifolius) Protein Hydrolysate Exerts Anxiolytic-Like Effects in Western Diet-Fed ApoE−/− Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (17), 9828. https://doi.org/10.3390/ijms23179828. |
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Lupinus angustifolius.pdf | 2.274Mb | ![]() | Ver/ | |