dc.creator | Santos-Sánchez, Guillermo | es |
dc.creator | Ponce España, Eduardo | es |
dc.creator | López García, Juan Carlos | es |
dc.creator | Álvarez-Sánchez, Nuria | es |
dc.creator | Álvarez López, Ana Isabel | es |
dc.creator | Pedroche, Justo | es |
dc.creator | Millán-Linares, María del Carmen | es |
dc.creator | Lardone, Patricia Judith | es |
dc.creator | Bejarano, Ignacio | es |
dc.creator | Cruz Chamorro, Iván | es |
dc.creator | Carrillo Vico, Antonio | es |
dc.date.accessioned | 2023-07-11T12:47:20Z | |
dc.date.available | 2023-07-11T12:47:20Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Santos-Sánchez, G., Ponce España, E., López García, J.C., Álvarez-Sánchez, N., Álvarez López, A.I., Pedroche, J.,...,Carrillo Vico, A. (2022). A Lupin (Lupinus angustifolius) Protein Hydrolysate Exerts Anxiolytic-Like Effects in Western Diet-Fed ApoE−/− Mice. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (17), 9828. https://doi.org/10.3390/ijms23179828. | |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/147868 | |
dc.description.abstract | Anxiety is the most prevalent psychiatric disorder worldwide, causing a substantial
economic burden due to the associated healthcare costs. Given that commercial anxiolytic treatments
may cause important side effects and have medical restrictions for prescription and high costs, the
search for new natural and safer treatments is gaining attention. Since lupin protein hydrolysate
(LPH) has been shown to be safe and exert anti-inflammatory and antioxidant effects, key risk factors
for the anxiety process and memory impairment, we evaluated in this study the potential effects of
LPH on anxiety and spatial memory in a Western diet (WD)-induced anxiety model in ApoE−/−
mice. We showed that 20.86% of the 278 identified LPH peptides have biological activity related to
anxiolytic/analgesic effects; the principal motifs found were the following: VPL, PGP, YL, and GQ.
Moreover, 14 weeks of intragastrical LPH treatment (100 mg/kg) restored the WD-induced anxiety
effects, reestablishing the anxiety levels observed in the standard diet (SD)-fed mice since they spent
less time in the anxiety zones of the elevated plus maze (EPM). Furthermore, a significant increase
in the number of head dips was recorded in LPH-treated mice, which indicates a greater exploration
capacity and less fear due to lower levels of anxiety. Interestingly, the LPH group showed similar
thigmotaxis, a well-established indicator of animal anxiety and fear, to the SD group, counteracting
the WD effect. This is the first study to show that LPH treatment has anxiolytic effects, pointing to
LPH as a potential component of future nutritional therapies in patients with anxiety. | es |
dc.format | application/pdf | es |
dc.format.extent | 16 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI AG | es |
dc.relation.ispartof | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (17), 9828. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Lupin | es |
dc.subject | Peptides | es |
dc.subject | Protein hydrolysates | es |
dc.subject | Anxiety | es |
dc.subject | ApoE−/− | es |
dc.subject | Functional foods | es |
dc.subject | Peptidomics | es |
dc.title | A Lupin (Lupinus angustifolius) Protein Hydrolysate Exerts Anxiolytic-Like Effects in Western Diet-Fed ApoE−/− Mice | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psicología Experimental | es |
dc.relation.projectID | AGL2012-40247-C02-01, AGL2012-40247-C02-02 | es |
dc.relation.projectID | PC-0111-2016-0111, PEMP-0085-2020 | es |
dc.relation.publisherversion | https://www.mdpi.com/1422-0067/23/17/9828 | es |
dc.identifier.doi | 10.3390/ijms23179828 | es |
dc.journaltitle | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | es |
dc.publication.volumen | 23 | es |
dc.publication.issue | 17 | es |
dc.publication.initialPage | 9828 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.contributor.funder | Consejería de Salud. Junta de Andalucía. | es |