dc.creator | Arnold, Anne Sophie | es |
dc.creator | Gill, Jonathan | es |
dc.creator | Christe, Martine | es |
dc.creator | Ruiz Laza, Rocío | es |
dc.creator | McGuirk, Shawn | es |
dc.creator | St-Pierre, Julie | es |
dc.creator | Tabares, Lucía | es |
dc.creator | Handschin, Christoph | es |
dc.date.accessioned | 2023-05-19T13:26:40Z | |
dc.date.available | 2023-05-19T13:26:40Z | |
dc.date.issued | 2014-04-04 | |
dc.identifier.citation | Arnold, A.S., Gill, J., Christe, M., Ruiz Laza, R., McGuirk, S., St-Pierre, J.,...,Handschin, C. (2014). Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha. NATURE COMMUNICATIONS, 5, 3569. https://doi.org/10.1038/ncomms4569. | |
dc.identifier.issn | 2041-1723 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146456 | |
dc.description.abstract | The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In
the mature muscle, the relative levels of physical activity are the major determinants of NMJ
function. Classically, motor neuron-mediated activation patterns of skeletal muscle have been
thought of as the major drivers of NMJ plasticity and the ensuing fibre-type determination in
muscle. Here we use muscle-specific transgenic animals for the peroxisome proliferatoractivated receptor g co-activator 1a (PGC-1a) as a genetic model for trained mice to elucidate
the contribution of skeletal muscle to activity-induced adaptation of the NMJ. We find that
muscle-specific expression of PGC-1a promotes a remodelling of the NMJ, even in the
absence of increased physical activity. Importantly, these plastic changes are not restricted to
post-synaptic structures, but extended to modulation of presynaptic cell morphology and
function. Therefore, our data indicate that skeletal muscle significantly contributes to the
adaptation of the NMJ subsequent to physical activity | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | NATURE PUBLISHING GROUP | es |
dc.relation.ispartof | NATURE COMMUNICATIONS, 5, 3569. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.relation.publisherversion | https://www.nature.com/articles/ncomms4569 | es |
dc.identifier.doi | 10.1038/ncomms4569 | es |
dc.journaltitle | NATURE COMMUNICATIONS | es |
dc.publication.volumen | 5 | es |
dc.publication.initialPage | 3569 | es |