Artículo
Transcriptomic analysis reveals an association of FCGBP with Parkinson’s disease
Autor/es | Gómez Garre, Pilar
Periñán Tocino, María Teresa Jesús, Silvia Bacalini, Maria Giulia Garagnani, Paolo Mollenhauer, Brit Pirazzini, Chiara Provini, Federica Trenkwalder, Claudia Franceschi, Claudio Mir Rivera, Pablo ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2022-11-12 |
Fecha de depósito | 2023-05-08 |
Publicado en |
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Resumen | Transcriptomics in Parkinson’s disease (PD) offers new insights into the molecular mechanism of PD pathogenesis. Several pathways, such as inflammation and protein degradation, have been identified by differential gene ... Transcriptomics in Parkinson’s disease (PD) offers new insights into the molecular mechanism of PD pathogenesis. Several pathways, such as inflammation and protein degradation, have been identified by differential gene expression analysis. Our aim was to identify gene expression differences underlying the disease etiology and the discovery of pre-symptomatic risk biomarkers for PD from a multicenter study in the context of the PROPAG-AGEING project. We performed RNA sequencing from 47 patients with de novo PD, 10 centenarians, and 65 healthy controls. Using identified differentially expressed genes, functional annotations were assigned using gene ontology to unveil significant enriched biological processes. The expression of 16 selected genes was validated using OpenArray® assays and samples from independent cohorts of 201 patients with advanced PD, 340 healthy siblings of PD patients, and 177 healthy controls. Differential gene expression analysis identified higher FCGBP expression in patients with de novo PD compared with healthy controls and compared with centenarians. Furthermore, FCGBP showed no differences in terms of population origin or aging process. The increased FCGBP expression was validated in patients with advanced PD and their siblings. Thus, we provided evidence for an upregulation of FCGBP mRNA levels not only in patients with PD but also in individuals at putative higher risk of PD, suggesting that it could be important in gut–brain PD interaction, mediating the connection between microbiota and intestinal inflammatory processes, as well as neuroinflammation and neurodegeneration. |
Agencias financiadoras | Programa "Juan Rodes" del Instituto de Salud Carlos III. Fondos FEDER Programa "Miguel Servet" del Instituto de Salud Carlos III. Fondos FEDER Programa "Nicolas Monardes" de la Consejería de Salud de la Junta de Andalucía Programa Marco Horizonte 2020 Ministerio de Educación, Cultura y Deporte (MECD). España |
Identificador del proyecto | B-0007-2019
![]() MSII14/00018 ![]() C-0048-2017 ![]() 634821 ![]() FPU16/05061 ![]() |
Cita | Gómez Garre, P., Periñán Tocino, M.T., Jesús, S., Bacalini, M.G., Garagnani, P., Mollenhauer, B.,...,Mir Rivera, P. (2022). Transcriptomic analysis reveals an association of FCGBP with Parkinson’s disease. NPJ Parkinson's Disease, 8 (1), 157. https://doi.org/10.1038/s41531-022-00415-7. |
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