NameMir Rivera, Pablo
DepartmentMedicina
Knowledge areaMedicina
Professional categoryProfesor Titular de Universidad (Pza. V)
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PhD Thesis
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Estudio de biomarcadores de neuroimagen multimodal implicados en la enfermedad de Parkinson

Labrador Espinosa, Miguel Ángel; Grothe, Michel J.; Mir Rivera, Pablo (2024)
Las discinesias inducidas por levodopa (DILs) y el deterioro cognitivo constituyen unas de las manifestaciones clínicas ...
PhD Thesis
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Estudio de la respuesta inmune periférica en la enfermedad de Parkinson

Muñoz Delgado, Laura; Mir Rivera, Pablo (2023)
Los mecanismos fisiopatológicos implicados de la enfermedad de Parkinson (EP) no se conocen por completo, pero la evidencia ...
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Peripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease

Muñoz-Delgado, Laura; Macías-García, Daniel; Periñán, María Teresa; Jesús, Silvia; Adarmes-Gómez, Astrid D.; Bonilla Toribio, Marta; García Díaz, Sergio; Mir Rivera, Pablo (Springer, 2023)
Peripheral inflammatory immune responses are thought to play a major role in the pathogenesis of Parkinson’s disease (PD). ...
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Embracing monogenic Parkinson's disease: the MJFF global genetic PD cohort

Vollstedt, Eva Juliane; Schaake, Susen; Lohmann, Katja; Padmanabhan, Shalini; Brice, Alexis; Lesage, Suzanne; Mir Rivera, Pablo; Klein, Christine (Wiley, 2023)
ABSTRACT: Background: As gene-targeted therapies are increasingly being developed for Parkinson’s disease (PD), identifying ...
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Homocysteine levels, genetic background, and cognitive impairment in Parkinson’s disease

Periñán Tocino, María Teresa; Macías García, Daniel; Jesús, Silvia; Martín Rodríguez, Juan Francisco; Muñoz Delgado, Laura; Jiménez Jaraba, María Valle; Mir Rivera, Pablo (Springer Nature, 2023)
Background: Hyperhomocysteinemia is considered an independent risk factor for cognitive impairment. Objective: To study ...
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Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Jain, Pritesh; Miller-Fleming, Tyne; Topaloudi, Apostolia; Yu, Dongmei; Drineas, Petros; Georgitsi, Marianthi; Mir Rivera, Pablo; Paschou, Peristera (Nature Publishing Group, 2023)
Tourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a ...
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Mendelian randomisation confirms the role of Y-chromosome loss in Alzheimer’s disease aetiopathogenesis in men

García-González, Pablo; Rojas, Itziar de; Moreno-Grau, Sonia; Montrreal, Laura; Puerta, Raquel; Alarcón-Martín, Emilio; Mir Rivera, Pablo; Ruiz, Agustín (MDPI, 2023)
Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with ...
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Sex differences in motor and non-motor symptoms among Spanish patients with Parkinson’s disease

Santos-García, Diego; Laguna, Ariadna; Hernández-Vara, Jorge; de Deus Fonticoba, Teresa; Cores Bartolomé, Carlos; Feal Painceiras, María J.; Mir Rivera, Pablo (MDPI, 2023)
Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations ...
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Falls predict acute hospitalization in Parkinson's disease

Santos García, Diego; de Deus Fonticoba, Teresa; Cores, Carlos; Suárez Castro, Ester; Hernández Vara, Jorge; Jesús, Silvia; Mir Rivera, Pablo; Martínez-Martín, Pablo (IOS Press, 2023)
Background: There is a need for identifying risk factors for hospitalization in Parkinson’s disease (PD) and also ...
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Corticospinal adaptations following resistance training and its relationship with strength: A systematic review and multivariate meta-analysis

Gómez Feria, José; Martín Rodríguez, Juan Francisco; Mir Rivera, Pablo (Elsevier, 2023)
Neural adaptations to resistance training (RT) and their correlation with muscle strength remain partially understood. We ...
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Mutations, Genes, and Phenotypes Related to Movement Disorders and Ataxias

Martínez Rubio, Dolores; Hinarejos, Isabel; Sancho, Paula; Gorría Redondo, Nerea; Bernadó Fonz, Raquel; Tello, Cristina; Mir Rivera, Pablo; Espinós, Carmen (MDPI, 2022)
Our clinical series comprises 124 patients with movement disorders (MDs) and/or ataxia with cerebellar atrophy (CA), many ...
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Efficacy and safety clinical trial with efavirenz in patients diagnosed with adult Niemann-pick type C with cognitive impairment

Gascón Bayarri, Jordi; Simon, Petru Cristian; Llop, Roser; Carnaval, Thiago; Ledesma, María Dolores; Rico, Imma; Mir Rivera, Pablo; Videla, Sebastián (Lippincott, Williams & Wilkins, 2022)
Background: Niemann-Pick disease Type C (NPC) is a genetic, incurable, neurodegenerative disorder. This orphan disease ...
PhD Thesis
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Estudio de la vía cerebelo-cortical en el síndrome de Tourette mediante estimulación magnética transcraneal

Álvarez de Toledo Blandón, María de la Paloma; Mir Rivera, Pablo; Martín Rodríguez, Juan Francisco (2022)
El síndrome de Tourette (ST) es un trastorno del neurodesarrollo caracterizado por la presencia de tics motores y vocales ...
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Transcriptomic analysis reveals an association of FCGBP with Parkinson’s disease

Gómez Garre, Pilar; Periñán Tocino, María Teresa; Jesús, Silvia; Bacalini, Maria Giulia; Garagnani, Paolo; Mollenhauer, Brit; Pirazzini, Chiara; Provini, Federica; Trenkwalder, Claudia; Franceschi, Claudio; Mir Rivera, Pablo (Nature Research, 2022)
Transcriptomics in Parkinson’s disease (PD) offers new insights into the molecular mechanism of PD pathogenesis. Several ...
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Enhancing neuroimaging genetics through meta-analysis for Tourette syndrome (ENIGMA-TS) A worldwide platform for collaboration

Paschou, Peristera; Jin, Yin; Müller-Vahl, Kirsten; Möller, Harald E.; Rizzo, Renata; Hoekstra, Pieter J.; Mir Rivera, Pablo; Martín Rodríguez, Juan Francisco; Black, Kevin J. (Frontiers Media, 2022)
Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric ...
PhD Thesis
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Estudio de factores genéticos y otros marcadores moleculares en la enfermedad de Parkinson

Periñán Tocino, María Teresa; Mir Rivera, Pablo; Gómez Garre, María del Pilar (2022)
La enfermedad de Parkinson (EP) es el segundo trastorno neurodegenerativo más común, que afecta al 2-3% de la población ...
PhD Thesis
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Biomarcadores séricos y riesgo vascular en la enfermedad de Parkinson esporádica y familiar

Macías García, Daniel; Mir Rivera, Pablo (2022)
La enfermedad de Parkinson (EP) es una enfermedad neurodegenerativa cuya etiopatogenia aún se desconoce en su totalidad. ...
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Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson’s disease patients

Meoni, Gaia; Tenori, Leonardo; Schade, Sebastian; Licari, Cristina; Pirazzini, Chiara; Bacalini, Maria Giulia; Periñán Tocino, María Teresa; Labrador-Espinosa, Miguel Á.; Mir Rivera, Pablo; Luchinat, Claudio (SPRINGER, 2022)
Parkinson’s disease (PD) is the neurological disorder showing the greatest rise in prevalence from 1990 to 2016. Despite ...
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Hair cortisol‑a stress marker in children and adolescents with chronic tic disorders? A large European cross‑sectional study

Buse, Judith; Rothe, Josefine; Uhlmann, Anne; Bodmer, Benjamin; Kirschbaum, Clemens; Hoekstra, Pieter J.; Dietrich, Andrea; Roessner, Veit; Mir Rivera, Pablo (Springer, 2022)
Background There is clear evidence that tic disorders (TDs) are associated with psychosocial stress as well as emotional ...
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Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson’s disease patients

Zago, Elisa; Dal Molin, Alessandra; Dimitri, Giovanna Maria; Xumerle, Luciano; Pirazzini, Chiara; Bacalini, Maria Giulia; Periñán Tocino, María Teresa; Mir Rivera, Pablo; Labrador-Espinosa, Miguel Á. (Nature Publishing Group, 2022)
Advanced age represents one of the major risk factors for Parkinson’s Disease. Recent biomedical studies posit a role for ...
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Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study

Santos García, Diego; Deus Fonticoba, Teresa de; Cores Bartolomé, Carlos; Feal Painceiras, María; Suárez Castro, Ester; Canfield, Héctor; Mir Rivera, Pablo (MDPI, 2022)
Objective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson’s ...
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MNCD: A New Tool for Classifying Parkinson’s Disease in Daily Clinical Practice

Santos García, Diego; Álvarez Sauco, María; Calopa, Matilde; Carrillo, Fátima; Escamilla-Sevilla, Francisco; Freire, Eric; Mir Rivera, Pablo; Sesar Ignacio, Ángel (MDPI, 2022)
Background and objective: Parkinson’s disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis ...
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Increased Stroke Risk in Patients with Parkinson’s Disease with LRRK2 Mutations

Macías-García, Daniel; Periñán Tocino, María Teresa; Muñoz Delgado, Laura; Jesús, Silvia; Jiménez Jaraba, María Valle; Buiza Rueda, Dolores; Bonilla Toribio, Marta; Adarmes-Gómez, Astrid; Carrillo, Fátima; Gómez Garre, Pilar; Mir Rivera, Pablo (WILEY, 2022)
Parkinson’s disease (PD) is associated with an increasedstroke risk, however, no relationship between coronary arterydisease ...
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Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

Storm, Catherine S.; Kia, Demis A.; Almramhi, Mona M.; Bandres-Ciga, Sara; Finan, Chris; Hingorani, Aroon D.; Wood, Nicholas W.; Mir Rivera, Pablo; Periñán Tocino, María Teresa (Nature Research, 2021)
Parkinson’s disease is a neurodegenerative movement disorder that currently has no disease-modifying treatment, partly ...
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Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease

Martínez Horta, Saul; Bejr-Kasem, Helena; Horta Barba, Andrea; Pascual Sedano, Berta; Santos García, Diego; Deus Fonticoba, Teresa de; Mir Rivera, Pablo; Kulisevsky, Jaime (BMC, 2021)
Background Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) ...
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Clinical Practice Patterns in Tic Disorders Among Movement Disorder Society Members

Ganos, Christos; Sarva, Harini; Kurvits, Lille; Gilbert, Donald L.; Hartmann, Andreas; Worbe, Yulia; Mir Rivera, Pablo; Martino, Davide (Ubiquity Press, 2021)
Background: Tic disorders belong to the broad spectrum of pediatric and adult movement disorders. The wide variability in ...
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Predictors of Loss of Functional Independence in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group

Santos García, Diego; Deus Fonticoba, Teresa de; Cores Bartolomé, Carlos; Naya Ríos, Lucía; García Roca, Lucía; Mir Rivera, Pablo;  (MDPI, 2021)
Background and objective: The aim of this study was to compare the progression of independence in activities of daily ...
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Insights into the expanding phenotypic spectrum of inherited disorders of biogenic amines

Kuseyri Hübschmann, Oya; Horvath, Gabriella; Cortès-Saladelafont, Elisenda; Yıldız, Yılmaz; Mastrangelo, Mario; Pons, Roser; Mir Rivera, Pablo; Opladen, Thomas (Nature Research, 2021)
Inherited disorders of neurotransmitter metabolism are rare neurodevelopmental diseases presenting with movement disorders ...
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Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients

Baldelli, Luca; Schade, Sebastian; Jesús Maestre, Silvia; Schreglmann, Sebastian R.; Gómez Garre, María del Pilar; Mir Rivera, Pablo; Labrador-Espinosa, Miguel Á.; Periñán Tocino, María Teresa (Nature Research, 2021)
A prodromal phase of Parkinson’s disease (PD) may precede motor manifestations by decades. PD patients’ siblings are at ...
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Investigation of gene–environment interactions in relation to tic severit

Abdulkadir, Mohamed; Yu, Dongmei; Osiecki, Lisa; King, Robert A.; Fernandez, Thomas V.; Brown, Lawrence W.; Mir Rivera, Pablo; Hoekstra, Pieter J. (Springer, 2021)
Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investi ...
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Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project

Santos García, Diego; Blázquez-Estrada, Marta; Calopa, Matilde; Escamilla-Sevilla, Francisco; Freire, Eric; Mir Rivera, Pablo; Luquín, María-Rosario (MDPI, 2021)
Abstract: Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common neurodegenerative ...
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Assessment of intellectual impairment, health-related quality of life, and behavioral phenotype in patients with neurotransmitter related disorders Data from the iNTD registry

Keller, Mareike; Brennenstuhl, Heiko; Kuseyri Hübschmann, Oya; Manti, Filippo; Julia Palacios, Natalia Alexandra; Friedman, Jennifer; Mir Rivera, Pablo; Cheuk Wing (Spinger, 2021)
Inherited disorders of neurotransmitter metabolism are a group of rare diseases, which are caused by impaired synthesis, ...
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Predictors of global non-motor symptoms burden progression in Parkinson’s disease. Results from the COPPADIS cohort at 2-year follow-up

Santos García, Diego; Deus, Teresa de; Cores, Carlos; Canfield, Hector; Paz González, José M.; Martínez Miró, Cristina; Mir Rivera, Pablo (MDPI, 2021)
Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson’s disease (PD) patients. ...
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In vivo cholinergic basal forebrain degeneration and cognition in Parkinson's disease: Imaging results from the COPPADIS study

Grothe, Michel J.; Labrador-Espinosa, Miguel Á.; Silvia, Jesús; Macías-García, Daniel; Adarmes-Gómez, Astrid; Carrillo, Fátima; Iglesias Camacho, Elena; Franco-Rosado, Pablo; Roldán Lora, Florinda; Martin Rodríguez, Juan Francisco; Mir Rivera, Pablo; Aguilar Barberá, Miquel; Escalante Arroyo, Sonia; Solano Vila, Berta; de Deus Fonticoba, Teresa; Carrillo Padilla, Francisco; Infante Ceberio, Jon; Hernández Vara, Jorge; de Fábregues Boixar, Oriol; Kulisevsky, Jaime; Martínez Martín, Pablo; Santos García, Diego; Pastor, Pau; Ruíz Martínez, Javier; Cots Foraster, Anna; Pueyo Morlans, Mercedes; Pascual Sedano, Berta; González Aramburu, Isabel (Elsevier, 2021)
Introduction: We aimed to assess associations between multimodal neuroimaging measures of cholinergic basal forebrain (CBF) ...
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Staging Parkinson’s disease combining motor and nonmotor symptoms correlates with disability and quality of life

Santos García, D.; de Deus Fonticoba, T.; Paz González, J. M.; Cores Bartolomé, C.; Valdés Aymerich, L.; Muñoz Enríquez, J. G.; Mir Rivera, Pablo; Martínez-Martín, P. (HINDAWI LTD, 2021)
In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow to know ...
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Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage

Chen, Zhongbo; Zhang, David; Reynolds, Regina H.; Labrador-Espinosa, Miguel Á.; Periñán Tocino, María Teresa; Mir Rivera, Pablo; Ryten, Mina (Nature Research, 2021)
Knowledge of genomic features specific to the human lineage may provide insights into brain-related diseases. We leverage ...
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Mapa epidemiológico transversal de las ataxias y paraparesias espásticas hereditarias en España

Ortega Suero, G.; Abenza Abildúa, M. J.; Serrano Munuera, C.; Rouco Axpe, I.; Arpa Gutiérrez, F. J.; Adarmes Gómez, A. D.; Mir Rivera, Pablo; Sobrido Gómez, M. J. (Elsevier, 2021)
Introducción Las ataxias (AT) y paraparesias espásticas hereditarias (PEH) son síndromes neurodegenerativos raros. Nos ...
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Uso de la infusión intestinal continua de levodopa-carbidopa en pacientes con enfermedad de Parkinson avanzada en España. Subanálisis por comunidades autónomas

Santos-García, D.; Catalán, M.J.; Puente, V.; Valldeoriola, F.; Regidor, I.; Mir Rivera, Pablo (Elsevier, 2021)
Objetivos: Comparar las características de los pacientes con enfermedad de Parkinson avan- zada en tratamiento con infusión ...
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A European Observational Study to Evaluate the Safety and the Effectiveness of Safinamide in Routine Clinical Practice: The SYNAPSES Trial

Abbruzzese, Giovanni; Kulisevsky, Jaime; Bergmans, Bruno; Gómez Esteban, Juan C.; Kägi, Georg; Raw, Jason; Stefani, Alessandro; Warnecke, Tobias; Jost, Wolfgang H.; Mir Rivera, Pablo (IOS Press, 2021)
Background: Safinamide modulates both dopaminergic and glutamatergic systems with positive effects on motor and non-motor ...
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Manejo de la enfermedad de Parkinson y otros trastornos del movimiento en mujeres en edad fértil: parte 2

García-Ramos, R.; Santos-García, D.; Alonso-Cánovas, A.; Álvarez-Sauco, M.; Ares, B.; Ávila, A.; Mir Rivera, Pablo (Science Direct, 2021)
Introducción Muchas enfermedades que cursan con trastornos del movimiento hipercinético comienzan o afectan a mujeres en ...
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Genomic characterization of host factors related to SARS-CoV-2 infection in people with dementia and control populations: the GR@ACE/DEGESCO study

Rojas, Itziar de; Hernández, Isabel; Montrreal, Laura; Quintela, Inés; Calero, Miguel; Royo, José Luis; Macías Sánchez, Juan; Pineda Vergara, Juan Antonio; Mir Rivera, Pablo; Ruiz, Agustín (MDPI, 2021)
Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility ...
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Synaptic processes and immune-related pathways implicated in Tourette syndrome

Madruga Garrido, Marcos; Mir Rivera, Pablo (NATURE PUBLISHING GROUP, 2021)
Tourette syndrome (TS) is a neuropsychiatric disorder of complex genetic architecture involving multiple interacting genes. ...
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Spinocerebellar ataxia type 8: First families detected in Spain

Arias, M.; Mir Rivera, Pablo; Fernández-Matarrubia, M.; Arpa, J.; García-Ramos, R.; Blanco-Arias, P.; Quintans, B.; Sobrido, M. J (Elsevier Doyma, 2021)
Introducción La ARCA1/SCAR8 es una heredoataxia recesiva causada por mutaciones en el gen SYNE1, que fue descrita inicialmente ...
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Long runs of homozygosity are associated with Alzheimer’s disease

Moreno-Grau, Sonia; Fernández, María Victoria; de Rojas, Itziar; García-González, Pablo; Hernández, Isabel; Farias, Fabiana; Pineda Vergara, Juan Antonio; Macías Sánchez, Juan; Mir Rivera, Pablo; Periñán Tocino, María Teresa (Nature Publishing Group, 2021)
Long runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of inbreeding and ...
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Directional deep brain stimulation for Parkinson's disease: results of an international crossover study with randomized, double-blind primary endpoint

Schnitzler, A.; Mir Rivera, Pablo; Brodsky, M. A.; Verhagen, L.; Groppa, S.; Álvarez, R.; Vesper, J. (Blackwell Publishing INC, 2021)
Objective: Published reports on directional deep brain stimulation (DBS) have been limited to small, single-center ...
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Predictors of clinically significant quality of life impairment in Parkinson’s disease

Santos García, Diego; Deus Fonticoba, Teresa de; Cores, Carlos; Muñoz, Guillermo; Paz González, José M.;; Martínez Miró, Cristina; Mir Rivera, Pablo (Springer, 2021)
Quality of life (QOL) plays an important role in independent living in Parkinson’s disease (PD) patients, being crucial ...
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Diplopia is frequent and associated with motor and non-motor severity in Parkinson’s disease: results from the COPPADIS cohort at 2-year follow-up

Santos García, Diego; Naya Ríos, Lucía; Deus Fonticoba, Teresa de; Cores Bartolomé, Carlos; García Roca, Lucía; Feal Painceiras, María; Mir Rivera, Pablo (MDPI, 2021)
Background and objective: Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was ...
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Manejo de la enfermedad de Parkinson y otros trastornos del movimiento en mujeres en edad fértil: Parte 1

García-Ramos, R.; Santos-García, D.; Alonso-Cánovas, A.; Álvarez-Sauco, M.; Ares, B.; Ávila, A.; Mir Rivera, Pablo; Martínez Castrillo, J. C. (Science Direct, 2021)
Introducción El manejo de la enfermedad de Parkinson en la mujer en edad fértil nos plantea como principal reto el manejo ...
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Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

de Rojas, Itziar; Moreno-Grau, Sonia; Tesi, Niccolo; Grenier-Boley, Benjamin; Andrade, Victor; Jansen, Iris E.; Macías Sánchez, Juan; Mir Rivera, Pablo; Periñán Tocino, María Teresa; Rodriguez-Rodriguez, Eloy (NATURE PUBLISHING GROUP, 2021)
ARTICLE Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores Genetic discoveries of ...
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NR4A2 Mutations Can Cause Intellectual Disability and Language Impairment With Persistent Dystonia-Parkinsonism

Jesús, Silvia; Hinarejos, Isabel; Carrillo, Fátima; Martínez Rubio, Dolores; Macías-García, Daniel; Sánchez-Monteagudo, Ana; Adarmes, Astrid; Mir Rivera, Pablo; Espinós, Carmen (2021)
The NR4A2/NURR1 gene (MIM*601828) has recently been associated with autosomal-dominant early-onset dystonia-parkinsonism ...
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Consenso de expertos españoles sobre el uso de la safinamida en la enfermedad de Parkinson

Valldeoriola, F.; Grandas, F.; Arbelo, J. M.; Blázquez Estrada, M.; Mir Rivera, Pablo; Yáñez Baña, R. M. (Science Direct, 2021)
La safinamida es un nuevo fármaco para el tratamiento de pacientes con enfermedad de Parkinson (EP) con fluctuaciones como ...
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Levodopa-induced dyskinesia in Parkinson disease specifically associates with dopaminergic depletion in sensorimotor-related functional subregions of the striatum

Labrador-Espinosa, Miguel Á.; Grothe, Michel J.; Macías-García, Daniel; Jesús, Silvia; Adarmes-Gómez, Astrid; Muñoz-Delgado, Laura; Fernández-Rodríguez, Paula; Martín Rodríguez, Juan Francisco; García-Solís, David; Mir Rivera, Pablo (Lippincott, Williams & Wilkins, 2021)
Purpose: To determine whether the development of levodopa-induced dyskinesia (LID) in Parkinson disease (PD) specifically ...
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Serum lipid profile among sporadic and familial forms of Parkinson's disease

Macías-García, D.; Periñán Tocino, María Teresa; Muñoz-Delgado, L.; Jiménez-Jaraba, M. V.; Labrador-Espinosa, Miguel Á.; Jesús, S.; Buiza-Rueda, D.; Mir Rivera, Pablo (Springer, 2021)
Brain cholesterol metabolism has been described as altered in Parkinson’s disease (PD) patients. Serum lipid levels have ...
PhD Thesis
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Predictores pronósticos en los trastornos psicóticos agudos y transitorios

López Díaz, Álvaro; Ruiz Veguilla, Miguel; Mir Rivera, Pablo (2020)
En la Décima Revisión de la Clasificación Internacional de Enfermedades (CIE-10) se introdujo la categoría ' trastornos ...
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Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information

Guelfi, Sebastian; D’Sa, Karishma; Botía, Juan A.; Vandrovcova, Jana; Reynolds, Regina H.; Zhang, David; Mir Rivera, Pablo; Labrador-Espinosa, Miguel Á.; Periñán Tocino, María Teresa (Nature publishing group, 2020)
Genome-wide association studies have generated an increasing number of common genetic variants associated with neurological ...
PhD Thesis
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Evaluación neuropsicológica y neurofisiológica en pacientes adultos con diabetes mellitus tipo 1

Castellano Guerrero, Ana María; Martínez Brocca, María Asunción; Mir Rivera, Pablo (2020)
Objetivos: Estudiar si existen evidencias de deterioro cognitivo en pacientes adultos con Diabetes Mellitus tipo 1 (DM1) ...
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A genetic analysis of a Spanish population with early onset Parkinson’s disease

Tejera-Parrado, Cristina; Mir Rivera, Pablo; Teresa Periñán, María; Vela Desojo, Lydia; Abreu Rodríguez, Irene; Alonso Cánovas, Araceli; Gómez-Garre, Pilar (Public Library Science, 2020)
Introduction Both recessive and dominant genetic forms of Parkinson’s disease have been described. The aim of this study ...
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Non‑motor symptom burden in patients with parkinson’s disease with impulse control disorders and compulsive behaviours: results from the coppADiS cohort

Jesús, S.; Labrador Espinosa, Miguel Ángel; Adarmes, A. D.; Méndel del Barrio, C.; Martínez Castrillo, J. C.; Alonso Cánovas, Araceli; Mir Rivera, Pablo (Springer Nature, 2020)
The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in ...
PhD Thesis
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Estudio de las bases genéticas implicadas en la enfermedad de Parkinson

Tejera Parrado, Cristina; Gómez Garre, María del Pilar; Mir Rivera, Pablo (2019)
La enfermedad de Parkinson (EP) es la segunda enfermedad neurodegenerativa más común caracterizada por la degeneración de ...
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Quantitative Intensity Harmonization of Dopamine Transporter SPECT Images Using Gamma Mixture Models

Llera, Alberto; Huertas Fernández, Ismael; Mir Rivera, Pablo; Beckmann, Christian F. (Springer, 2018)
PURPOSE: Differences in site, device, and/or settings may cause large variations in the intensity profile of dopamine ...
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European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents

Schrag, Anette; Martino, Davide; Apter, Alan; Ball, Juliane; Bartolini, Erika; Benaroya-Milshtein, Noa; Buttiglione, Maura; Cardona, Francesco; Mir Rivera, Pablo (Springer Berlin Heidelberg, 2018)
Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal ...
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Consenso de expertos españoles sobre el uso de la safinamida en la enfermedad de Parkinson

Valldeoriola, F.; Grandas, F.; Arbelo, J. M.; Blázquez Estrada, M.; Calopa Garriga, M.; Mir Rivera, Pablo (Elsevier, 2018)
La safinamida es un nuevo fármaco para el tratamiento de pacientes con enfermedad de Parkinson (EP) con fluctuaciones como ...
PhD Thesis
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Clinical correlates and advanced processing of the dopamine transporter spect - applications in parkinsonism

Huertas Fernández, Ismael; Mir Rivera, Pablo (2017)
La visualización del transportador de dopamina (DAT) a través del SPECT con [123I]FP-CIT es una prueba de imagen ampliamente ...
PhD Thesis
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Estudio mediante estimulación magnética transcraneal del cerebelo y de la corteza parietal posterior en la distonia primaria cervical

Porcacchia, Paolo; Mir Rivera, Pablo (2017)
III. OBJETIVOS DEL ESTUDIO OBJETIVOS GENERALES En los pacientes con distonía primaria cervical conocer el funcionamiento ...
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Consensus on the Definition of Advanced Parkinson's Disease: A Neurologists-Based Delphi Study (CEPA Study)

Luquin, MR; Kulisevsky, Jaime; Martinez Martin, Pablo; Mir Rivera, Pablo; Tolosa, Eduardo (Hindawi, 2017)
To date, no consensus exists on the key factors for diagnosing advanced Parkinson disease (APD). To obtain consensus on ...
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Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease

Huertas Fernández, Ismael; Jesús, Silvia; García Gómez, Francisco Javier; Lojo, José Antonio; Bernal Bernal, Inmaculada; Bonilla Toribio, Marta; Martín Rodríguez, Juan Francisco; García Solís, David; Gómez Garre, María del Pilar; Mir Rivera, Pablo (Public Library of Science, 2017)
The dual syndrome hypothesis for cognitive impairment in Parkinson's disease (PD) establishes a dichotomy between a ...
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Tremor stability index: a new tool for differential diagnosis in tremor syndromes

Di Biase, Lazzaro; Brittain, John-Stuart; Shah, Syed Ahmar; Pedrosa, David J.; Cagnan, Hayriye; Mathy, Alexandre; Chen, Chiung Chu; Martín Rodríguez, Juan Francisco; Mir Rivera, Pablo; Timmerman, Lars; Schwingenschuh, Petra; Bhatia, Kailash; Di Lazzaro, Vincenzo; Brown, Peter (Oxford University Press, 2017)
Misdiagnosis among tremor syndromes is common, and can impact on both clinical care and research. To date no validated ...
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GBA Variants Influence Motor and Non-Motor Features of Parkinson’s Disease.

Jesús Maestre, Silvia; Huertas Fernández, Ismael; Bernal Bernal, Inmaculada; Bonilla Toribio, Marta; Cáceres-Redondo, María Teresa; Vargas González, Laura; Calderón Sandubete, Enrique José; Mir Rivera, Pablo (Public Library Of Science, 2016)
The presence of mutations in glucocerebrosidase (GBA) gene is a known factor increasing the risk of developing Parkinson’s ...
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The social impact of Parkinson’s disease in Spain: Report by the Spanish Foundation for the Brain

García- Ramos, R.; López Valdés, E.; Ballesteros, L.; Jesús, S.; Mir Rivera, Pablo (Elsevier, 2016)
Introduction: Understanding the social and economic impact of Parkinson’s disease is essential for resource planning and ...
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Trait- and state-dependent cortical inhibitory deficits in bipolar disorder

Ruiz Veguilla, Miguel; Martín Rodríguez, Juan Francisco; Palomar, Francisco J.; Porcacchia, Paolo; Álvarez de Toledo, Paloma; Perona Garcelán, Salvador Félix; Rodríguez Testal, Juan Francisco; Huertas-Fernández, Ismael; Mir Rivera, Pablo (Wiley, 2016)
Objectives Euthymic patients with bipolar disorder (BD) have deficits in cortical inhibition. However, whether cortical ...
PhD Thesis
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Características clínicas, neurofisiológicas y de imagen con SPECT I123-FP-CIT en el parkinsonismo vascular

Benítez Rivero, Sonia; Mir Rivera, Pablo (2015)
La definición actual de parkinsonismo vascular (PV) es la aparición de signos parkinsonianos (definido por la presencia ...
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Aberrant cortical associative plasticity associated with severe adult Tourette syndrome

Martín Rodríguez, Juan Francisco; Ruiz Rodríguez, María Adilia; Palomar, Francisco J.; Cáceres Redondo, María Teresa; Vargas, Laura; Porcacchia, Paolo; Gómez-Crespo, Mercedes; Huertas-Fernández, Ismael; Carrillo, Fátima; Madruga-Garrido, Marcos; Mir Rivera, Pablo (Wiley, 2015)
Background. Recent studies have shown altered cortical plasticity in adult patients with Tourette syndrome. However, the ...
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Machine learning models for the differential diagnosis of vascular parkinsonism and Parkinson's disease using [(123)I]FP-CIT SPECT

Huertas Fernández, Ismael; García Gómez, Francisco Javier; García Solís, David; Benítez Rivero, Sonia; Marín Oyaga, Víctor A.; Jesús, Silvia; Cáceres Redondo, María Teresa; Lojo, José Antonio; Martín Rodríguez, Juan Francisco; Carrillo García, Fátima María; Mir Rivera, Pablo (Springer, 2015)
Purpose: The study’s objective was to develop diagnostic predictive models using data from two commonly used [(123)I]FP-CIT ...
PhD Thesis
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Estudio del papel del cerebelo en la enfermedad de Parkinson mediante estimulación magnética transcraneal

Carrillo García, Fátima María; Mir Rivera, Pablo; Villar Ortiz, José (2014)
Se han descrito cambios funcionales en la activación del cerebelo en la enfermedad de Parkinson (EP) mediante diferentes ...
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Effects of Two Weeks of Cerebellar Theta Burst Stimulation in Cervical Dystonia Patients

Koch, Giacomo; Porcacchia, Paolo; Carrillo, Fátima; Cáceres-Redondo, María Teresa; Brusa, Livia; Mir Rivera, Pablo (Elsevier, 2014)
Dystonia is generally regarded as a disorder of the basal ganglia and their efferent connections to the thalamus and ...
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Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia

Porcacchia, Paolo; Palomar, Francisco J.; Cáceres-Redondo, María Teresa; Huertas Fernández, Ismael; Martín Rodríguez, Juan Francisco; Carrillo, Fátima; Koch, Giacomo; Mir Rivera, Pablo (Elsevier, 2014)
Background: Dystonia is considered as a motor network disorder involving the dysfunction of the posterior parietal cortex, ...
PhD Thesis
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Estudio mediante estimulación magnética transcraneal de las cortezas somatosensorial primaria y parietal posterior en la enfermedad de Parkinson

Palomar Simón, Francisco José; Mir Rivera, Pablo (2012)
La enfermedad de parkinson (ep) es la segunda enfermedad neurodegenerativa más frecuente detrás de la enfermedad de ...