Artículo
Homocysteine levels, genetic background, and cognitive impairment in Parkinson’s disease
Autor/es | Periñán Tocino, María Teresa
Macías García, Daniel Jesús, Silvia Martín Rodríguez, Juan Francisco Muñoz Delgado, Laura Jiménez Jaraba, María Valle Mir Rivera, Pablo |
Departamento | Universidad de Sevilla. Departamento de Psicología Experimental Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2023 |
Fecha de depósito | 2023-05-23 |
Publicado en |
|
Resumen | Background: Hyperhomocysteinemia is considered an independent risk factor for cognitive impairment.
Objective: To study the correlation between homocysteine levels and cognitive impairment in patients with PD.
Methods: ... Background: Hyperhomocysteinemia is considered an independent risk factor for cognitive impairment. Objective: To study the correlation between homocysteine levels and cognitive impairment in patients with PD. Methods: We conducted a case–control study that included 246 patients with PD, of whom 32 were cognitively impaired. The levels of homocysteine, folate, and vitamin B12 were measured in peripheral blood. Multivariate logistic regression analysis was applied to determine differences in homocysteine levels between PD patients with and without cognitive impairment. A meta-analysis was performed to clarify the role of Hcy levels in PD with cognitive decline. Five polymorphisms in genes involved in Hcy metabolism, including MTHFR rs1801133 and rs1801131, COMT rs4680, MTRR rs1801394, and TCN2 rs1801198, were genotyped. Results: Our case–control study showed that homocysteine levels were associated with cognitive impairment in PD after adjusting for possible confounding factors such as levodopa equivalent daily dose. The results of our meta-analysis further supported the positive association between homocysteine levels and cognition in PD. We found that the MTHFR rs1801133 TT genotype led to higher homocysteine levels in PD patients, whereas the MTHFR rs1801131 CC genotype resulted in higher folate levels. However, the polymorphisms studied were not associated with cognitive impairment in PD. Conclusions: Increased homocysteine levels were a risk factor for cognitive decline in PD. However, no association was found between polymorphisms in genes involved in homocysteine metabolism and cognitive impairment in PD. Large-scale studies of ethnically diverse populations are required to definitively assess the relationship between MTHFR and cognitive impairment in PD. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Instituto de Salud Carlos III European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Junta de Andalucía Universidad de Sevilla |
Identificador del proyecto | RTC2019-007150-1
PI14/01823 PI16/01575 PI18/01898 PI19/01576 CVI-02526 CTS-7685 PI-0471-2013 PE-0210-2018 PI-0459-2018 PE-0186-2019 C-0048-2017 B-0007-2019 CM18/00142 USE-18817-A CM21/00051 |
Cita | Periñán Tocino, M.T., Macías García, D., Jesús, S., Martín Rodríguez, J.F., Muñoz Delgado, L., Jiménez Jaraba, M.V. y Mir Rivera, P. (2023). Homocysteine levels, genetic background, and cognitive impairment in Parkinson’s disease. Journal of Neurology, 270, 477-485. https://doi.org/10.1007/s00415-022-11361-y. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
s00415-022-11361-y(1).pdf | 658.4Kb | [PDF] | Ver/ | |