Artículo
Staging Parkinson’s disease combining motor and nonmotor symptoms correlates with disability and quality of life
Autor/es | Santos García, D.
de Deus Fonticoba, T. Paz González, J. M. Cores Bartolomé, C. Valdés Aymerich, L. Muñoz Enríquez, J. G. Mir Rivera, Pablo Martínez-Martín, P. |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2021-05-15 |
Fecha de depósito | 2022-11-15 |
Publicado en |
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Resumen | In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow to
know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr’s ... In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr’s motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient’s quality of life (QoL) with regard to a defined clinical stage. Materials and Methods. Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0–20; B: NMSS = 21–40; C: NMSS = 41–70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p < 0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p < 0.005; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p < 0.0001). Conclusion. +e HY.NMSB scale is simple and reflects the degree of patient in volvement more accurately than the H&Y. Patients with a lower H&Y stage may be more affected if they have a greater NMS burden. |
Cita | Santos García, D., de Deus Fonticoba, T., Paz González, J.M., Cores Bartolomé, C., Valdés Aymerich, L., Muñoz Enríquez, J.G.,...,Martínez-Martín, P. (2021). Staging Parkinson’s disease combining motor and nonmotor symptoms correlates with disability and quality of life. Parkinsons Disease, 2021, 8871549. https://doi.org/10.1155/2021/8871549. |
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