dc.creator | Santos García, D. | es |
dc.creator | de Deus Fonticoba, T. | es |
dc.creator | Paz González, J. M. | es |
dc.creator | Cores Bartolomé, C. | es |
dc.creator | Valdés Aymerich, L. | es |
dc.creator | Muñoz Enríquez, J. G. | es |
dc.creator | Mir Rivera, Pablo | es |
dc.creator | Martínez-Martín, P. | es |
dc.date.accessioned | 2022-11-15T16:53:31Z | |
dc.date.available | 2022-11-15T16:53:31Z | |
dc.date.issued | 2021-05-15 | |
dc.identifier.citation | Santos García, D., de Deus Fonticoba, T., Paz González, J.M., Cores Bartolomé, C., Valdés Aymerich, L., Muñoz Enríquez, J.G.,...,Martínez-Martín, P. (2021). Staging Parkinson’s disease combining motor and nonmotor symptoms correlates with disability and quality of life. Parkinsons Disease, 2021, 8871549. https://doi.org/10.1155/2021/8871549. | |
dc.identifier.issn | 2090-8083 | es |
dc.identifier.issn | 2042-0080 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139458 | |
dc.description.abstract | In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow to
know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr’s motor stage (H&Y) and the
nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the
disability and the patient’s quality of life (QoL) with regard to a defined clinical stage. Materials and Methods. Cross-sectional
study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4,
stage IV/V) and NMSB (A: NMSS � 0–20; B: NMSS � 21–40; C: NMSS � 41–70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A
to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL
(Activities of Daily Living) scale. Results. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB
(p < 0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less
autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p < 0.005; e.g., PDQ-39SI in 1D [n � 15] vs 2A
[n � 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; p < 0.0001). Conclusion. +e HY.NMSB scale is simple and reflects the degree of patient in volvement more accurately than the H&Y. Patients with a lower H&Y stage may be more affected if they have a greater
NMS burden. | es |
dc.format | application/pdf | es |
dc.format.extent | 16 p. | es |
dc.language.iso | eng | es |
dc.publisher | HINDAWI LTD | es |
dc.relation.ispartof | Parkinsons Disease, 2021, 8871549. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Parkinson’s Disease | es |
dc.subject | Neurodegenerative disorder | es |
dc.subject | Motor and nonmotor symptoms (NMS) | es |
dc.title | Staging Parkinson’s disease combining motor and nonmotor symptoms correlates with disability and quality of life | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.hindawi.com/journals/pd/2021/8871549/ | es |
dc.identifier.doi | 10.1155/2021/8871549 | es |
dc.journaltitle | Parkinsons Disease | es |
dc.publication.volumen | 2021 | es |
dc.publication.initialPage | 8871549 | es |