Article
The Multitasker Protein: A Look at the Multiple Capabilities of NUMB
Author/s | Ortega Campos, Sara M.
García Heredia, José Manuel |
Department | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular |
Publication Date | 2023 |
Deposit Date | 2023-04-20 |
Published in |
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Abstract | NUMB, a plasma membrane-associated protein originally described in Drosophila, is involved in determining cell function and fate during early stages of development. It is secreted asymmetrically in dividing cells, with one ... NUMB, a plasma membrane-associated protein originally described in Drosophila, is involved in determining cell function and fate during early stages of development. It is secreted asymmetrically in dividing cells, with one daughter cell inheriting NUMB and the other inheriting its antagonist, NOTCH. NUMB has been proposed as a polarizing agent and has multiple functions, including endocytosis and serving as an adaptor in various cellular pathways such as NOTCH, Hedgehog, and the P53-MDM2 axis. Due to its role in maintaining cellular homeostasis, it has been suggested that NUMB may be involved in various human pathologies such as cancer and Alzheimer’s disease. Further research on NUMB could aid in understanding disease mechanisms and advancing the field of personalized medicine and the development of new therapies. |
Funding agencies | Ministerio de Ciencia e Innovación (MICIN). España Centro de Investigación Biomédica en Red (CIBER) Consejeria de Salud Asociación Española Contra el Cáncer (AECC) |
Project ID. | RTI2018-097455-B-I00
PID2021-122629OB-I00 CB16/12/00275 PI-0397-2017 GC16173720CAR |
Citation | Ortega Campos, S.M. y García Heredia, J.M. (2023). The Multitasker Protein: A Look at the Multiple Capabilities of NUMB. Cells, 12 (2), 333. https://doi.org/10.3390/cells12020333. |
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