NameGarcía Heredia, José Manuel
DepartmentBioquímica Vegetal y Biología Molecular
Knowledge areaBioquímica y Biología Molecular
Professional categoryProfesor Titular de Universidad
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  • No. publications

    25

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Presentation
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A Feature Selection and Association Rule Approach to Identify Genes Associated with Metastasis and Low Survival in Sarcoma

Linares Barrera, María Lourdes; Martínez Ballesteros, María del Mar; García Heredia, José Manuel; Riquelme Santos, José Cristóbal (SpringerLink, 2023)
Sarcomas are rare mesodermal tumors of heterogeneous nature and have a higher incidence in children. The relative 5-year ...
Article
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The Multitasker Protein: A Look at the Multiple Capabilities of NUMB

Ortega Campos, Sara M.; García Heredia, José Manuel (Multidisciplinary Digital Publishing Institute (MDPI), 2023)
NUMB, a plasma membrane-associated protein originally described in Drosophila, is involved in determining cell function ...
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A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules

García Heredia, José Manuel; Perez, Marco; Verdugo Sivianes, Eva María; Martínez Ballesteros, María del Mar; Ortega Campos, Sara M.; Carnero, Amancio (Springer Nature, 2023)
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PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208

Muñoz Galván, Sandra; Rivero, María; Peinado Serrano, Javier; Martinez Pérez, Julia; Fernández Fernández, María del Carmen; Ortiz, María José; García Heredia, José Manuel; Carnero Moya, Amancio (MDPI, 2020)
Colorectal cancer (CRC) is the third most common cancer worldwide. The standard treatment in locally advanced rectal cancer ...
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Autoencoded DNA methylation data to predict breast cancer recurrence: Machine learning models and gene-weight significance

Macías García, Laura; Martínez Ballesteros, María del Mar; Luna Romera, José María; García Heredia, José Manuel; García Gutiérrez, Jorge; Riquelme Santos, José Cristóbal (Elsevier, 2020)
Breast cancer is the most frequent cancer in women and the second most frequent overall after lung cancer. Although the ...
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Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment

Pérez, Marco; García Heredia, José Manuel; Felipe Abrio, Blanca; Muñoz Galván, Sandra; Martín Broto, Javier; Carnero Moya, Amancio (Springer Nature, 2020)
Sarcomas constitute a rare heterogeneous group of tumors, including a wide variety of histological subtypes. Despite ...
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Role of Mitochondria in Cancer Stem Cell Resistance

García Heredia, José Manuel; Carnero Moya, Amancio (Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Cancer stem cells (CSC) are associated with the mechanisms of chemoresistance to different cytotoxic drugs or radiotherapy, ...
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Breast tumor cells promotes the horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein between subsets of neoplastic cells

García Heredia, José Manuel; Otero Albiol, Daniel; Pérez, Marco; Pérez Castejón, Elena; Muñoz Galván, Sandra; Carnero, Amancio (Springer Nature, 2020)
MAP17 (PDZK1IP1) is a small protein regulating inflammation and tumor progression, upregulated in a broad range of carcinomas. ...
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New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools

Muñoz Galván, Sandra; Felipe Abrio, Blanca; García Carrasco, Miguel; Domínguez Piñol, Julia; Suarez Martínez, Elisa; Verdugo Sivianes, Eva María; Espinosa Sánchez, Asunción; Navas Maldonado, Lola Eufemia; Otero Abiol, Daniel; García Heredia, José Manuel; Carnero Moya, Amancio (BMC, 2019)
BACKGROUND: Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and ...
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Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseases

García Heredia, José Manuel; Carnero Moya, Amancio (BioMed Central, 2018)
Inflammation is a common defensive response that is activated after different harmful stimuli. This chronic, or ...
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MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma

Ferrer, Irene; Quintanal Villalonga, Álvaro Diego; Molina Pinelo, Sonia; García Heredia, José Manuel; Pérez, Marco; Carnero Moya, Amancio (BMC, 2018)
Background The high incidence and mortality of lung tumours is a major health problem. Therefore, the identification both ...
Article
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NUMB and NUMBL differences in gene regulation

García Heredia, José Manuel; Carnero Moya, Amancio (Impact Journals, 2018)
NUMB, and its close homologue NUMBL, behave as tumor suppressor genes by regulating the Notch pathway. The downregulation ...
Article
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The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB

García Heredia, José Manuel; Lucena Cacace, Antonio; Verdugo Sivianes, Eva María; Pérez, Marco; Carnero Moya, Amancio (American Association for Cancer Research, 2017)
Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor ...
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Machine learning techniques to discover genes with potential prognosis role in Alzheimer’s disease using different biological sources

Martínez Ballesteros, María del Mar; García Heredia, José Manuel; Nepomuceno Chamorro, Isabel de los Ángeles; Riquelme Santos, José Cristóbal (Elsevier, 2017)
Alzheimer’s disease is a complex progressive neurodegenerative brain disorder, being its prevalence ex pected to rise over ...
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The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment

García Heredia, José Manuel; Carnero Moya, Amancio (Impact Journals, 2017)
Inflammation is a complex defensive response activated after various harmful stimuli allowing the clearance of damaged ...
Article
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Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer

Verdugo Sivianes, Eva María; Navas, Lola; Molina Pinelo, Sonia; Quintanal Villalonga, Álvaro Diego; García Heredia, José Manuel; Felipe Abrio, Blanca; Muñoz Galván, Sandra (Impact Journals, 2017)
The scaffold protein Spinophilin (Spinophilin, PPP1R9B) is one of the regulatory subunits of phosphatase-1 (PP1), directing ...
Presentation
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Discovery of Genes Implied in Cancer by Genetic Algorithms and Association Rules

Sánchez Medina, Alejandro; Gil Pichardo, Alberto; García Heredia, José Manuel; Martínez Ballesteros, María del Mar (Springer, 2016)
This work proposes a methodology to identify genes highly related with cancer. In particular, a multi-objective evolutionary ...
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Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy

García Heredia, José Manuel; Verdugo Sivianes, Eva María; Lucena Cacace, Antonio; Molina Pinelo, Sonia; Carnero Moya, Amancio (Impact Journals, 2016)
NumbL, or Numb-like, is a close homologue of Numb, and is part of an evolutionary conserved protein family implicated in ...
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Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1

Pérez, Marco; Peinado Serrano, Javier; García Heredia, José Manuel; Felipe Abrio, Irene; Tous Rivera, Cristina; Ferrer, Irene; Martín Broto, Javier (Impact Journals, 2016)
Sarcomas are malignant tumors accounting for a high percentage of cancer morbidity and mortality in children and young ...
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Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain

García Heredia, José Manuel; Carnero Moya, Amancio (Impact Journals, 2015)
Otto Warburg observed that cancer cells derived their energy from aerobic glycolysis by converting glucose to lactate. ...
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Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome

García Heredia, José Manuel; Díaz Moreno, Irene; Díaz Quintana, Antonio Jesús; Orzáez, Mar; Navarro Carruesco, José Antonio; Hervás Morón, Manuel; Rosa Acosta, Miguel Ángel de la (Elsevier, 2012)
Under nitroxidative stress, a minor fraction of cytochrome c can be modified by tyrosine nitration. Here we analyze the ...
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Cytochrome c signalosome in mitochondria

Díaz Moreno, Irene; García Heredia, José Manuel; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Springer, 2011)
Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life ...
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Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation

García Heredia, José Manuel; Díaz Moreno, Irene; Nieto Mesa, Pedro Manuel; Orzáez, Mar; Kocanis, Stella; Teixeira, Miguel; Pérez Payá, Enrique; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la (Elsevier, 2010)
Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure ...
Patent. Invention
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Construcción génica que codifica para el citocromo c y procedimiento de obtención

Rosa Acosta, Miguel Ángel de la; Cerda Haynes, Berta de la; Molina Heredia, Fernando Publio; Rodríguez Roldán, Vicente; Hervás Morón, Manuel; García Heredia, José Manuel; Navarro Carruesco, José Antonio (Oficina Española de Patentes y Marcas (OEPM), 2009)
Construcción génica que codifica para el citocromo c y procedimiento de obtención. Se describe una construcción génica que ...
PhD Thesis
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Análisis comparado en animales y plantas de la función del citocromo c respiratorio en el proceso de muerte celular programada

García Heredia, José Manuel; Rosa Acosta, Miguel Ángel de la; Navarro Carruesco, José Antonio (2008)