Perfil del autor: García Heredia, José Manuel
Datos institucionales
| Nombre | García Heredia, José Manuel |
| Departamento | Bioquímica Vegetal y Biología Molecular |
| Área de conocimiento | Bioquímica y Biología Molecular |
| Categoría profesional | Profesor Titular de Universidad |
| Correo electrónico | Solicitar |
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Estadísticas
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Nº publicaciones
25
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Nº visitas
2411
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Nº descargas
3435
| Publicaciones |
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Ponencia
 A Feature Selection and Association Rule Approach to Identify Genes Associated with Metastasis and Low Survival in Sarcoma
(SpringerLink, 2023)
Sarcomas are rare mesodermal tumors of heterogeneous nature and have a higher incidence in children. The relative 5-year ... |
Artículo
The Multitasker Protein: A Look at the Multiple Capabilities of NUMB
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
NUMB, a plasma membrane-associated protein originally described in Drosophila, is involved in determining cell function ... |
| Artículo |
Artículo
PAI1 is a Marker of Bad Prognosis in Rectal Cancer but Predicts a Better Response to Treatment with PIM Inhibitor AZD1208
(MDPI, 2020)
Colorectal cancer (CRC) is the third most common cancer worldwide. The standard treatment in locally advanced rectal cancer ... |
Artículo
Autoencoded DNA methylation data to predict breast cancer recurrence: Machine learning models and gene-weight significance
(Elsevier, 2020)
Breast cancer is the most frequent cancer in women and the second most frequent overall after lung cancer. Although the ... |
Artículo
Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment
(Springer Nature, 2020)
Sarcomas constitute a rare heterogeneous group of tumors, including a wide variety of histological subtypes. Despite ... |
Artículo
Role of Mitochondria in Cancer Stem Cell Resistance
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Cancer stem cells (CSC) are associated with the mechanisms of chemoresistance to different cytotoxic drugs or radiotherapy, ... |
Artículo
Breast tumor cells promotes the horizontal propagation of EMT, stemness, and metastasis by transferring the MAP17 protein between subsets of neoplastic cells
(Springer Nature, 2020)
MAP17 (PDZK1IP1) is a small protein regulating inflammation and tumor progression, upregulated in a broad range of carcinomas. ... |
Artículo
New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools
(BMC, 2019)
BACKGROUND: Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and ... |
Artículo
Dr. Jekyll and Mr. Hyde: MAP17’s up-regulation, a crosspoint in cancer and inflammatory diseases
(BioMed Central, 2018)
Inflammation is a common defensive response that is activated after different harmful stimuli. This chronic, or ... |
Artículo
MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma
(BMC, 2018)
Background The high incidence and mortality of lung tumours is a major health problem. Therefore, the identification both ... |
Artículo
NUMB and NUMBL differences in gene regulation
(Impact Journals, 2018)
NUMB, and its close homologue NUMBL, behave as tumor suppressor genes by regulating the Notch pathway. The downregulation ... |
Artículo
The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB
(American Association for Cancer Research, 2017)
Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor ... |
Artículo
Machine learning techniques to discover genes with potential prognosis role in Alzheimer’s disease using different biological sources
(Elsevier, 2017)
Alzheimer’s disease is a complex progressive neurodegenerative brain disorder, being its prevalence ex pected to rise over ... |
Artículo
The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment
(Impact Journals, 2017)
Inflammation is a complex defensive response activated after various harmful stimuli allowing the clearance of damaged ... |
Artículo
Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer
(Impact Journals, 2017)
The scaffold protein Spinophilin (Spinophilin, PPP1R9B) is one of the regulatory subunits of phosphatase-1 (PP1), directing ... |
Ponencia
Discovery of Genes Implied in Cancer by Genetic Algorithms and Association Rules
(Springer, 2016)
This work proposes a methodology to identify genes highly related with cancer. In particular, a multi-objective evolutionary ... |
Artículo
Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy
(Impact Journals, 2016)
NumbL, or Numb-like, is a close homologue of Numb, and is part of an evolutionary conserved protein family implicated in ... |
Artículo
Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1
(Impact Journals, 2016)
Sarcomas are malignant tumors accounting for a high percentage of cancer morbidity and mortality in children and young ... |
Artículo
Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain
(Impact Journals, 2015)
Otto Warburg observed that cancer cells derived their energy from aerobic glycolysis by converting glucose to lactate. ... |
Artículo
Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome
(Elsevier, 2012)
Under nitroxidative stress, a minor fraction of cytochrome c can be modified by tyrosine nitration. Here we analyze the ... |
Artículo
Cytochrome c signalosome in mitochondria
(Springer, 2011)
Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life ... |
Artículo
Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation
(Elsevier, 2010)
Tyrosine nitration is one of the most common post-transcriptional modifications of proteins, so affecting their structure ... |
Patente. Invención
Construcción génica que codifica para el citocromo c y procedimiento de obtención
(Oficina Española de Patentes y Marcas (OEPM), 2009)
Construcción génica que codifica para el citocromo c y procedimiento de obtención. Se describe una construcción génica que ... |
| Tesis Doctoral |