Artículos (Bioquímica Vegetal y Biología Molecular)
Recent Submissions
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RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [Article]
(Elsevier, 2020)Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) ...
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An End to a Means: How DNA-End Structure Shapes the Double-Strand Break Repair Process [Article]
(Frontiers Media, 2020)Endogenously-arising DNA double-strand breaks (DSBs) rarely harbor canonical 5'-phosphate, 3'-hydroxyl moieties at the ends, which are, regardless of the pathway used, ultimately required for their repair. Cells are therefore ...
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Ubiquitin carboxyl-terminal hydrolases are required for period maintenance of the circadian clock at high temperature in Arabidopsis [Article]
(Nature Research, 2019)Protein ubiquitylation participates in a number of essential cellular processes including signal transduction and transcription, often by initiating the degradation of specific substrates through the 26S proteasome. Within ...
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The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [Article]
(American Association for Cancer Research, 2017)Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that ...
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Genes for asparagine metabolism in Lotus japonicus: Differential expression and interconnection with photorespiration [Article]
(Springer Nature, 2017)Background: Asparagine is a very important nitrogen transport and storage compound in plants due to its high nitrogen/carbon ratio and stability. Asparagine intracellular concentration depends on a balance between asparagine ...
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New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools [Article]
(BMC, 2019)BACKGROUND: Ovarian cancer is the leading cause of gynecologic cancer-related death, due in part to a late diagnosis and a high rate of recurrence. Primary and acquired platinum resistance is related to a low response ...
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Mujeres invisibles [Article]
(Universidad de Málaga (UMA), 2008)En el Prólogo del Informe "Política Científica en la Unión Europea: Promover la excelencia potenciando la igualdad de género", elaborado por el grupo ETAN de la Comisión Europea1, el entonces Comisario de Investigación ...
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The singular properties of photosynthetic cytochrome c 550 from the diatom Phaeodactylum tricornutum suggest new alternative functions [Article]
(Wiley-Blackwell, 2019)Cytochrome c 550 is an extrinsic component in the luminal side of photosystem II (PSII) in cyanobacteria, as well as in eukaryotic algae from the red photosynthetic lineage including, among others, diatoms. We have established ...
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Chloroplast Redox Regulatory Mechanisms in Plant Adaptation to Light and Darkness [Article]
(Frontiers Media, 2019)Light is probably the most important environmental stimulus for plant development. As sessile organisms, plants have developed regulatory mechanisms that allow the rapid adaptation of their metabolism to changes in light ...
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Paving the way for the production of secretory proteins by yeast cell factories [Article]
(Wiley Open Access, 2019) -
Regulation of K+ Nutrition in Plants [Article]
(Frontiers Media, 2019)Modern agriculture relies on mineral fertilization. Unlike other major macronutrients, potassium (K+) is not incorporated into organic matter but remains as soluble ion in the cell sap contributing up to 10% of the dry ...
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Cell stress by phosphate of two protozoa tetrahymena thermophila and tetrahymena pyriformis [Article]
(Scientific Research Publishing, 2017)Phosphorus is one of the bioelements most needed as a compound cell by living organisms. Phosphorus is involved in several pathologies: in human with bone and kidney diseases, in mammals with metabolism disorder (glucose, ...
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Inorganic Pyrophosphatases: Study of Interest [Article]
(Scientific Research Publishing, 2017)Inorganic pyrophosphatases are enzymes that catalyze the hydrolysis of inorganic pyrophosphate to orthophosphate. These enzymes are divided into two groups: the soluble pyrophosphatases and the membrane pyrophosphatases. ...
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N-terminal chimaeras with signal sequences enhance the functional expression and alter the subcellular localization of heterologous membrane-bound inorganic pyrophosphatases in yeast [Article]
(Portland Press, 2010)Expression of heterologous multispanning membrane proteins in Saccharomyces cerevisiae is a difficult task. Quite often, the use of multicopy plasmids where the foreign gene is under the control of a strong promoter does ...
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The ciliate protist tetrahymena pyriformis as a cellular adhesion model for the pathogenic bacterium staphylococcus aureus [Article]
(Scientific Research Publishing, 2017)Staphylococcus aureus is one of the main pathogenic agents responsible for nosocomial and community-acquired bacterial infections. The pathogenicity of this Gram-positive bacterium is ensured by its different adhesion ...
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Intracellular proton pumps as targets in chemotherapy: V-ATPases and cancer [Article]
(Bentham Science Publishers, 2012)Cancer cells show a metabolic shift that makes them overproduce protons; this has the potential to disturb the cellular acid-base homeostasis. However, these cells show cytoplasmic ...
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Intraorganellar acidification by V-ATPases: a target in cellproliferation and cancer therapy [Article]
(Bentham Science Publishers, 2010)V-ATPases are multicomponent proton pumps involved in the acidification of singlemembrane intracellular compartments such as endosomes and lysosomes. They couple thehydrolysis of ATP to the translocation of one to two ...
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Copper effect on cytochrome b559 of photosystem II under photoinhibitory conditions [Article]
(Wiley, 2004)Toxic Cu (II) effect on cytochrome b559 under aerobic photoinhibitory conditions was examined in two different photosystem II (PSII) membrane preparations active in oxygen evolution. The preparations differ in the content ...
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Peculiar properties of chlorophyll thermoluminescence emission of autotrophically or mixotrophically grown Chlamydomonas reinhardtii [Article]
(Elsevier, 2011)The microalgae Chlamydomonas reinhardtii and Chlorella sp. CCAP 211/84 were grown autotrophically and mixotrophically and their thermoluminescence emissions were recorded above 0 °C after excitation by 1, 2 or 3 xenon ...
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Photosynthetic cytochrome c550 [Article]
(Elsevier, 2012)Cytochrome c550 (cyt c550) is a membrane component of the PSII complex in cyanobacteria and some eukaryotic algae, such as red and brown algae. Cyt c550 presents a bis-histidine heme coordination which is very unusual for ...