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The Multitasker Protein: A Look at the Multiple Capabilities of NUMB

dc.creatorOrtega Campos, Sara M.es
dc.creatorGarcía Heredia, José Manueles
dc.date.accessioned2023-04-20T14:32:08Z
dc.date.available2023-04-20T14:32:08Z
dc.date.issued2023
dc.identifier.citationOrtega Campos, S.M. y García Heredia, J.M. (2023). The Multitasker Protein: A Look at the Multiple Capabilities of NUMB. Cells, 12 (2), 333. https://doi.org/10.3390/cells12020333.
dc.identifier.issn2073-4409es
dc.identifier.urihttps://hdl.handle.net/11441/144709
dc.description.abstractNUMB, a plasma membrane-associated protein originally described in Drosophila, is involved in determining cell function and fate during early stages of development. It is secreted asymmetrically in dividing cells, with one daughter cell inheriting NUMB and the other inheriting its antagonist, NOTCH. NUMB has been proposed as a polarizing agent and has multiple functions, including endocytosis and serving as an adaptor in various cellular pathways such as NOTCH, Hedgehog, and the P53-MDM2 axis. Due to its role in maintaining cellular homeostasis, it has been suggested that NUMB may be involved in various human pathologies such as cancer and Alzheimer’s disease. Further research on NUMB could aid in understanding disease mechanisms and advancing the field of personalized medicine and the development of new therapies.es
dc.description.sponsorshipMinisterio de Ciencia e Innovación RTI2018-097455-B-I00, PID2021-122629OB-I00es
dc.description.sponsorshipCentro de Investigación Biomédica en Red CB16/12/00275es
dc.description.sponsorshipConsejeria de Salud PI-0397-2017es
dc.description.sponsorshipAsociación Española Contra el Cáncer GC16173720CARes
dc.formatapplication/pdfes
dc.format.extent19 p.es
dc.language.isoenges
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es
dc.relation.ispartofCells, 12 (2), 333.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAlzheimeres
dc.subjectCanceres
dc.subjectDevelopmentes
dc.subjectIsoformses
dc.subjectNeurogenesises
dc.subjectNUMBes
dc.titleThe Multitasker Protein: A Look at the Multiple Capabilities of NUMBes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Moleculares
dc.relation.projectIDRTI2018-097455-B-I00es
dc.relation.projectIDPID2021-122629OB-I00es
dc.relation.projectIDCB16/12/00275es
dc.relation.projectIDPI-0397-2017es
dc.relation.projectIDGC16173720CARes
dc.relation.publisherversionhttps://dx.doi.org/10.3390/cells12020333es
dc.identifier.doi10.3390/cells12020333es
dc.journaltitleCellses
dc.publication.volumen12es
dc.publication.issue2es
dc.publication.initialPage333es
dc.contributor.funderMinisterio de Ciencia e Innovación (MICIN). Españaes
dc.contributor.funderCentro de Investigación Biomédica en Red (CIBER)es
dc.contributor.funderConsejeria de Saludes
dc.contributor.funderAsociación Española Contra el Cáncer (AECC)es

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