Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery
Pérez-Puyana, Víctor Manuel
Ostos Marcos, Francisco José
Sepúlveda Ferrer, Ranier Enrique
Romero García, Alberto
Rafii-El-Idrissi Benhnia, Mohammed
Chicardi Augusto, Ernesto
|Department||Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte
Universidad de Sevilla. Departamento de Ingeniería Química
Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología
|Abstract||A gelatin-based hydrogel was infiltrated and degraded-released in two different titanium foams with porosities of 30 and 60 vol.% (Ti30 and Ti60 foams) and fabricated by the space holder technique to evaluate its potential ...
A gelatin-based hydrogel was infiltrated and degraded-released in two different titanium foams with porosities of 30 and 60 vol.% (Ti30 and Ti60 foams) and fabricated by the space holder technique to evaluate its potential to act as an innovative, alternative, and localised method to introduce both active pharmaceutical ingredients, such as antibiotics and non-steroidal anti-inflammatory drugs, and growth factors, such as morphogens, required after bone-tissue replacement surgeries. In addition, the kinetic behaviour was studied for both infiltration and degradation-release processes. A higher infiltration rate was observed in the Ti60 foam. The maximum infiltration hydrogel was achieved for the Ti30 and Ti60 foams after 120 min and 75 min, respectively. Further, both processes followed a Lucas-Washburn theoretical behaviour, typical for the infiltration of a fluid by capillarity in porous channels. Regarding the subsequent degradation-release process, both systems showed similar exponential degradation performance, with the full release from Ti60 foam (80 min), versus 45 min for Ti30, due to the greater interconnected porosity open to the surface of the Ti60 foam in comparison with the Ti30 foam. In addition, the optimal biocompatibility of the hydrogel was confirmed, with the total absence of cytotoxicity and the promotion of cell growth in the fibroblast cells evaluated.
|Funding agencies||Universidad de Sevilla|
|Citation||Mehdi-Sefiani, H., Pérez-Puyana, V.M., Ostos Marcos, F.J., Sepúlveda Ferrer, R.E., Romero García, A., Rafii-El-Idrissi Benhnia, M. y Chicardi Augusto, E. (2023). Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery. Polymers, 15 (2), 275. https://doi.org/10.3390/polym15020275.|