Artículo
T-cells immune response controls the high incidence of adenovirus infection in adult allogenic hematopoietic transplantation recipients
Autor/es | Sánchez Céspedes, Javier
Marrugal-Lorenzo, José Antonio Martín-Gandul, Cecilia Rodríguez-Torres, Nancy Montero-Mateos, Enrique Serna Gallego, Ana Espigado Tocino, Ildefonso Pachón Díaz, Jerónimo Pérez Simón, José Antonio Aguilar-Guisado, Manuela |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2021-01 |
Fecha de depósito | 2022-12-22 |
Publicado en |
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Resumen | Human adenovirus (HAdV) can produce disseminated disease with high mortality in pediatric allogenic hematopoietic stem cell transplant (allo-HSCT) recipients. In adult recipients, prospective studies addressing the incidence ... Human adenovirus (HAdV) can produce disseminated disease with high mortality in pediatric allogenic hematopoietic stem cell transplant (allo-HSCT) recipients. In adult recipients, prospective studies addressing the incidence of HAdV infection and disease are lacking. The aim of this study was to characterize the kinetics of HAdV replication, the specific T-cell immune response, and the clinical impact of HAdV infection in adult allo- HSCT recipients. We found a high incidence of HAdV viremia, which was controlled by the T-cell immune response and without association with disseminated HAdV disease. Therefore, these data argue against the pre-emptive therapy for HAdV infection in adult allo- HSCT recipients. |
Cita | Sánchez Céspedes, J., Marrugal-Lorenzo, J.A., Martín-Gandul, C., Rodríguez-Torres, N., Montero-Mateos, E., Serna-Gallego, A.,...,Aguilar-Guisado, M. (2021). T-cells immune response controls the high incidence of adenovirus infection in adult allogenic hematopoietic transplantation recipients. Hematologica, 106 (1), 275-278. https://doi.org/10.3324/HAEMATOL.2019.240101. |
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