NamePérez Simón, José Antonio
DepartmentMedicina
Knowledge areaMedicina
Professional categoryProfesor Titular de Universidad (Pza. V)
E-mailRequest
       
  • No. publications

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Impact of disease burden and late loss of B cell aplasia on the risk of relapse after CD19 chimeric antigen receptor T Cell (Tisagenlecleucel) infusion in pediatric and young adult patients with relapse/refractory acute lymphoblastic leukemia: role of B-cell monitoring

Molinos-Quintana, Águeda; Alonso-Saladrigues, Anna; Herrero, Blanca; Caballero Velázquez, Teresa; Galán-Gómez, Víctor; Panesso, Melissa; Torrebadell, Montserrat; Delgado-Serrano, Javier; Pérez de Soto, Concepción; Pérez Simón, José Antonio (Frontiers Media S.A., 2024)
Introduction: Loss of B-cell aplasia (BCA) is a well-known marker of functional loss of CD19 CAR-T. Most relapses and loss ...
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Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions

Medrano, M.; Contreras, M.; Caballero Velázquez, Teresa; Martínez, L.; Bejarano-García, J. A.; Calderón Ruiz, Rocío; García-Calderón, C. B.; Valle Rosado, Iván; Pérez Simón, José Antonio (Nature Publishing Group, 2024)
BACKGROUND: Several studies have described a potential anti-tumour effect of cannabinoids (CNB). CNB receptor 2 (CB2) is ...
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Outcomes after intensive chemotherapy for secondary and myeloid-related changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry

Martínez-Cuadrón, David; Megías-Vericat, Juan E.; Gil, Cristina; Bernal, Teresa; Tormo, Mar; Martínez-Sánchez, Pilar; Rodríguez-Medina, Carlos; Serrano, Josefina; Herrera, Pilar; Pérez Simón, José Antonio (Ferrata Storti Foundation, 2024)
Treatment options for patients with secondary acute myeloid leukemia (sAML) and AML with myeloid-related changes (AMLMRC) ...
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ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party

Penack, Olaf; Peczynski, Christophe; Boreland, William; Lemaitre, Jessica; Afanasyeva, Ksenia; Kornblit, Brian; Pérez Simón, José Antonio; Peric, Zinaida (Frontiers Media S.A., 2023)
Introduction: Extracorporal Photophoresis (ECP) is in clinical use for steroidrefractory and steroid-dependent acute GVHD ...
PhD Thesis
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Uso de cannabinoides para el tratamiento de hemopatías malignas

Medrano Domínguez, María Teresa; Pérez Simón, José Antonio; Valle Rosado, Iván (2023)
Aunque el sistema hematopoyético e inmunológico muestran altos niveles del receptor cannabinoide CB2, el efecto de los ...
PhD Thesis
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Inhibición de la vía de señalización Hedgehog con glasdegib en pacientes con enfermedad injerto contra receptor crónica esclerodermiforme: resultados de un ensayo piloto de fase I/II

Rodríguez Arbolí, Eduardo; Pérez Simón, José Antonio (2023)
La enfermedad injerto contra receptor crónica esclerodermiforme (EICRcs) se caracteriza por la fibrosis cutánea progresiva ...
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Prognostic value of measurable residual disease in patients with AML undergoing HSCT: a multicenter study

Caballero Velázquez, Teresa; Pérez-López, Olga; Yeguas Bermejo, Ana; Rodríguez Arbolí, Eduardo; Colado Varela, Enrique; Sempere Talens, Amparo; Pérez Simón, José Antonio (MDPI, 2023)
Allogeneic hematopoietic stem cell transplantation (HSCT) represents the best therapeutic option for many patients with ...
PhD Thesis
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Leucemia mieloide aguda con cambios relacionados con mielodisplasia: caracterización citomorfológica, citogenética y molecular, y valor pronóstico de mutaciones en el gen ASXL1

Prats Martín, Concepción; Pérez Simón, José Antonio; Morales Camacho, Rosario María (2023)
La clasificación de las leucemias mieloides agudas (LMA) tiene como objeto la definición de entidades con un perfil clínico, ...
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Editorial: Regulatory T cells in graft versus host disease

Rodríguez Gil, Alfonso; Pérez Simón, José Antonio; Ritz, Jerome; Lacerda, João F.; Soares, Maria V.D. (Frontiers Media, 2023)
Regulatory T cells (Tregs) are modulators of the immune system that play a key role in maintaining self-tolerance. Treg ...
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Integrated flow cytometry and sequencing to reconstruct evolutionary patterns from dysplasia to acute myeloid leukemia

Simoes, Catia; Chillón, María Carmen; Martínez-Cuadrón, David; Calasanz, María José; Vridiales, María Belén; Vazquez, Iria; Ruano, Montserrat; Pérez Simón, José Antonio; Paiva, Bruno (Elsevier, 2023)
Clonal evolution in acute myeloid leukemia (AML) originates long before diagnosis and is a dynamic process that may affect ...
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Targeting Hedgehog Signaling with Glasdegib in Patients with Refractory Sclerotic Chronic GVHD: A Report of Two Phase I/II Trials

Rodríguez-Arbolí, Eduardo; Lee, Catherine J; Caballero Velázquez, Teresa; Martinez, Carmen; García Calderón, Clara Beatriz; Jiménez León, María Reyes; Bermudez-Rodriguez, Maria Aranzazu; Pérez Simón, José Antonio (American Association for Cancer Research, 2023)
Purpose: Sclerotic chronic GVHD (scGVHD) is characterized by progressive skin fibrosis and frequent refractoriness to ...
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Molecular landscape and validation of new genomic classification in 2668 adult AML patients: real life data from the PETHEMA registry

Sargas, Claudia; Ayala, Rosa; Larráyoz, María José; Chillón, María Carmen; Carrillo-Cruz, Estrella; Bilbao-Sieyro, Cristina; Pérez Simón, José Antonio; Montesinos, Pau (MDPI, 2023)
Next–Generation Sequencing (NGS) implementation to perform accurate diagnosis in acute myeloid leukemia (AML) represents ...
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All-trans retinoic acid works synergistically with the γ-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells

García-Guerrero, Estefanía; Rodríguez-Lobato, Luis G.; Sierro-Martínez, Belén; Danhof, Sophia; Bates, Stephan; Frenz, Silke; Pérez Simón, José Antonio; Prommersberger, Sabrina R. (Ferrata Storti Foundation, 2023)
B-cell maturation antigen (BCMA) is the lead antigen for chimeric antigen receptor (CAR) T-cell therapy in multiple ...
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LAG3 genotype of the donor and clinical outcome after allogeneic transplantation from HLA-identical sibling donors

Cruz, David; Rodríguez-Romanos, Rocío; González-Bartulos, Marta; García-Cadenas, Irene; de la Cámara, Rafael; Heras, Inmaculada; Pérez Simón, José Antonio; Gallardo, David (Frontiers Media S.A., 2023)
Introduction: The association of polymorphisms in molecules involved in the immune response (checkpoint inhibitors) with ...
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Monitoring of kinetics and exhaustion markers of circulating CAR-T cells as early predictive factors in patients with B-cell malignancies

García Calderón, Clara Beatriz; Sierro-Martínez, Belén; García-Guerrero, Estefanía; Sanoja-Flores, Luzalba; Muñoz-García, Raquel; Ruiz-Maldonado, Victoria; Carrasco-Brocal, Inmaculada; Pérez Simón, José Antonio; Caballero Velázquez, Teresa (Frontiers Media, 2023)
Purpose: CAR-T cell therapy has proven to be a disruptive treatment in the hematology field, however, less than 50% of ...
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A phase II, prospective, randomized, open-label study of defibrotide added to standard-of-care prophylaxis for the prevention of acute graft-versus-host disease after allogeneic hematopoietic cell transplantation

Hudspeth, Michelle; Mori, Shahram; Nachbaur, David; Pérez Simón, José Antonio; Stölzel, Friedrich; Riches, Marcie; Wu, Wendy; Zhang, Peixin; Agarwal, Shirali; Yakoub-Agha, Ibrahim (Ferrata Storti Foundation, 2023)
Acute graft-versus-host disease (aGvHD) is a life-threatening complication typically occurring within 100 days after ...
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Comparison of the 2022 and 2017 European LeukemiaNet risk classifications in a real-life cohort of the PETHEMA group

Sargas, C.; Ayala, R.; Larráyoz, M. J.; Chillón, M. C.; Rodríguez-Arboli, E.; Bilbao, C.; Pérez Simón, José Antonio; Montesinos, P. (Springer Nature, 2023)
Next-Generation Sequencing is needed for the accurate genetic risk stratification of acute myeloid leukemia according to ...
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Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression

Río, María Luisa del; Yago-Díez de Juan, Carla; Roncador, Giovanna; Caleiras, Eduardo; Álvarez-Esteban, Ramón; Pérez Simón, José Antonio; Rodríguez-Barbosa, José Ignacio (Frontiers Media S.A., 2023)
Introduction: A high frequency of mutations affecting the gene encoding Herpes Virus Entry Mediator (HVEM, TNFRSF14) is a ...
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First-in-human study of JNJ-63709178, a CD123/CD3 targeting antibody, in relapsed/refractory acute myeloid leukemia

Boyiadzis, Michael; Desai, Pinkal; Daskalakis, Nikki; Donnellan, William; Ferrante, Lucille; Goldberg, Jenna D.; Pérez Simón, José Antonio; Alonso-Domínguez, Juan Manuel (Wiley, 2022)
This study aimed to identify a recommended phase II dose and evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics, ...
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Impact of FLT3–ITD mutation status and its ratio in a cohort of 2901 patients undergoing upfront intensive chemotherapy: a PETHEMA registry study

Ayala, Rosa; Carreño-Tarragona, Gonzalo; Barragán, Eva; Boluda, Blanca; Larráyoz, María J.; Chillón, María Carmen; Pérez Simón, José Antonio; Montesinos, Pau (MDPI, 2022)
FLT3–ITD results in a poor prognosis in terms of overall survival (OS) and relapse-free survival (RFS) in acute myeloid ...
PhD Thesis
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Linfocitos T reguladores para pacientes con enfermedad injerto contra receptor crónica que no obtienen remisión completa con ruxolitinib

Escamilla Gómez, Virginia; Pérez Simón, José Antonio; Rodríguez Gil, Alfonso (2022)
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Combined treatment of graft versus host disease using donor regulatory T cells and ruxolitinib

Rodríguez Gil, Alfonso; Escamilla Gómez, Virginia; Nufer, Melanie; Andújar Sánchez, Félix; Lopes Ramos, Teresa; Bejarano García, José Antonio; Caballero Velázquez, Teresa; Villadiego Luque, Francisco Javier; Pérez Simón, José Antonio (Nature Publishing Group, 2022)
Donor derived regulatory T lymphocytes and the JAK1/2 kinase inhibitor ruxolitinib are currently being evaluated as ...
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Phase II Trial of Allogeneic Transplantation Plus Novel Drugs in Multiple Myeloma: Effect of Intensifying Reduced-Intensity Conditioning with Bortezomib and Adding Maintenance Treatment

Reinoso-Segura, Marta; Caballero Velázquez, Teresa; Herrera, Pilar; Patriarca, Francesca; Herrera, Pilar; Fanin, Renato; Bruno, Benedetto; Gahrton, Gösta; Pérez Simón, José Antonio (Elsevier Inc., 2022)
The use of reduced-intensity conditioning (RIC) regimens has decreased the risk of nonrelapse mortality (NRM) after ...
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Comparison of outcomes for HLA-matched sibling and haplo identical donors in Myelodysplastic syndromes: report from the chronic malignancies working party of EBMT

Raj, Kavita; Eikema, Dirk Jan; Sheth, Vipul; Koster, Linda; Wreede, Liesbeth C:; Blaise, Didier; Pérez Simón, José Antonio; Yakoub Agha, Ibrahim (Springer Nature, 2022)
Myelodysplastic syndromes (MDS) are the second common indication for an Allo-HCT. We compared the outcomes of 1414 matched ...
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CD4+ and CD8+ T-cell responses in bone marrow to fatty acids in high-fat diets

Medrano, Mayte; Lemus Conejo, Ana; López Martín, Sergio; Millán-Linares, María del Carmen; Rosillo Ramírez, María de los Ángeles; Muñiz Guinea, Manuel; Calderón Ruíz, Rocío; Pérez Simón, José Antonio; Abia González, María del Rocío (Elsevier, 2022)
Obesity is associated with disruptions in the adaptive immune system; however, dietary fatty acids in high-fat diets (HFDs) ...
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The impact of CD160 deficiency on alloreactive CD8 T cell responses and allograft rejection

Río, María Luisa del; Nguyen, Tuan H.; Tesson, Laurent; Heslan, Jean Marie; Gutiérrez-Adán, Alfonso; Fernández-González, Raúl; Pérez Simón, José Antonio; Rodríguez-Barbosa, José Ignacio (Elsevier, 2022)
CD160 is a member of the immunoglobulin superfamily with a pattern of expression mainly restricted to cytotoxic cells. To ...
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Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/ PD-1 Interaction and NK Cell Mediated Hybrid Resistance

Río, María Luisa del; Pérez Simón, José Antonio; Rodríguez-Barbosa, José Ignacio (FRONTIERS MEDIA SA, 2022)
The contribution of natural killer (NK) cells to tumor rejection in the context of programmed death-ligand 1/programmed ...
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Mesenchymal Stromal Cells for Treating Steroid-Resistant Acute and Chronic Graft Versus Host Disease: A Multicenter Compassionate Use Experience

Macías Sánchez, María Del Mar; Morata Tarifa, Cynthia; Cuende, Natividad; Cardesa Gil, Ana; Cuesta Casas, María Ángeles; Pascual Cascon, María Jesús; Pérez Simón, José Antonio; Espigado Tocino, Ildefonso; Sánchez Pernaute, Rosario (WILEY, 2022)
Graft versus host disease (GVHD) is a severe complication after allogenic hematopoietic cell transplantation (HSCT). Several ...
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Effect of Vitamin D on Graft-versus-Host Disease

Rodríguez Gil, Alfonso; Carrillo-Cruz, Estrella; Marrero-Cepeda, Cristina; Rodríguez, Guillermo; Pérez Simón, José Antonio (MDPI, 2022)
The different cell subsets of the immune system express the vitamin D receptor (VDR). Through the VDR, vitamin D exerts ...
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Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis

Fielding, Claire; García García, Andrés; Korn, Claudia; Gadomski, Stephen; Fang, Zijian; Reguera, Juan Luis; Pérez Simón, José Antonio; Göttgens, Berthold; Méndez Ferrer, Simón (Nature Publishing Group, 2022)
The sympathetic nervous system has been evolutionary selected to respond to stress and activates haematopoietic stem cells ...
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Spanish Society of Hematology and Hemotherapy expert consensus opinion for SARS-CoV-2 vaccination in onco-hematological patients

Piñana, José L.; Vázquez, Lourdes; Martino, Rodrigo; García Gutiérrez, Valentín; Pérez Simón, José Antonio; Hernández Rivas, José Ángel; Bosch, Francesc (Taylor & Francis LTD, 2022)
In the midst of the COVID-19 pandemic, different vaccines in front of SARS-CoV-2 have been approved and administered in ...
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Publisher correction: Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab (Leukemia, (2021), 35, 1, (201-214), 10.1038/s41375-020-0840-y)

García-Guerrero, Estefanía; Götz, Ralph; Doose, Sören; Sauer, Markus; Rodríguez Gil, Alfonso; Pérez Simón, José Antonio; Danhof, Sophia (Springer Nature, 2022)
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Networking for advanced molecular diagnosis in acute myeloid leukemia patients is possible: the PETHEMA NGS-AML project

Sargas, Claudia; Ayala, Rosa; Chillón, María del Carmen; Larráyoz, María J.; Carrillo-Cruz, Estrella; Bilbao, Cristina; Pérez Simón, José Antonio; Montesinos, Pau (Ferrata Storti Foundation, 2021)
Next-generation sequencing (NGS) has recently been introduced to efficiently and simultaneously detect genetic variations ...
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Current Status of CAR-T Cell Therapy in Multiple Myeloma

Reguera-Ortega, Juan Luis; García-Guerrero, Estefanía; Pérez Simón, José Antonio (MDPI, 2021)
Current data on CAR-T cell-based therapy is really promising in multiple myeloma, especially in terms of response. In ...
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Delayed administration of ixazomib modifies the immune response and prevents chronic graft-versus-host disease

Ramos, Teresa L.; García Guerrero, Estefanía; Caballero Velázquez, Teresa; Rodríguez Gil, Alfonso; Caracuel García, Rocío; Nufer, Melanie; Robles Frías, María José; Barbado González, Mª Victoria; Pérez Simón, José Antonio (Nature Publishing Group, 2021)
In this study, we aimed to modify the immune response in the long term after allogeneic bone marrow transplantation ...
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A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction

Millán-Uclés, África; Díaz-Castro, Blanca; García-Flores, Paula; Báez, Alicia; Pérez Simón, José Antonio; Piruat, José I. (Public Library Science, 2021)
Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/ paraganglioma ...
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Clinical benefit of glasdegib plus low-dose cytarabine in patients with de novo and secondary acute myeloid leukemia: long-term analysis of a phase II randomized trial

Heuser, Michael; Smith, B. Douglas; Fiedler, Walter; Sekeres, Mikkael A.; Montesinos, Pau; Leber, Brian; Pérez Simón, José Antonio; Cortes, Jorge E. (Springer, 2021)
This analysis from the phase II BRIGHT AML 1003 trial reports the long-term efficacy and safety of glasdegib + low-dose cytarabine ...
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MUFAs in High-Fat Diets Protect against Obesity-Induced Bias of Hematopoietic Cell Lineages

Lemus Conejo, Ana; Medrano, Mayte; López Martín, Sergio; Millán-Linares, María del Carmen; Rosillo Ramírez, María de los Ángeles; Pérez Simón, José Antonio; Muriana, Francisco J. G.; Abia González, María del Rocío (Wiley, 2021)
Scope: The role of dietary fatty acids in the generation of bone marrow (BM) immune cells and their trafficking to ...
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Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab

García-Guerrero, Estefanía; Götz, Ralph; Doose, Sören; Sauer, Markus; Rodríguez Gil, Alfonso; Pérez Simón, José Antonio; Danhof, Sophia (Nature Publishing Group, 2021)
Multiple myeloma (MM) is incurable, so there is a significant unmet need for effective therapy for patients with relapsed ...
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Long-Term Outcomes After Autologous Versus Allogeneic Stem Cell Transplantation in Molecularly-Stratified Patients With Intermediate Cytogenetic Risk Acute Myeloid Leukemia: A PETHEMA Study.

Rodríguez-Arbolí, Eduardo; Martínez-Cuadrón, David; Rodríguez-Veiga, Rebeca; Carrillo-Cruz, Estrella; Gil-Cortés, Cristina; Serrano-López, Josefina; Pérez Simón, José Antonio; Montesinos, Pau (Elsevier, 2021)
Acute myeloid leukemia (AML) with intermediate risk cytogenetics (IRcyto) comprises a variety of biological enti- ties ...
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Long-Term Impact of an Educational Antimicrobial Stewardship Program on Management of Patients with Hematological Diseases

Guisado Gil, Ana Belén; Aguilar Guisado, Manuela; Peñalva, Germán; Lepe Jiménez, José Antonio; Espigado Tocino, Ildefonso; Rodríguez-Arbolí, Eduardo; Pérez Simón, José Antonio; Cisneros, José Miguel;  (MDPI, 2021)
Antimicrobial stewardship programs (ASPs) in hematological patients are especially relevant. However, information about ...
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T-cells immune response controls the high incidence of adenovirus infection in adult allogenic hematopoietic transplantation recipients

Sánchez Céspedes, Javier; Marrugal-Lorenzo, José Antonio; Martín-Gandul, Cecilia; Rodríguez-Torres, Nancy; Montero-Mateos, Enrique; Serna Gallego, Ana; Espigado Tocino, Ildefonso; Pachón Díaz, Jerónimo; Pérez Simón, José Antonio; Aguilar Guisado, Manuela (FERRATA STORTI FOUNDATION, 2021)
Human adenovirus (HAdV) can produce disseminated disease with high mortality in pediatric allogenic hematopoietic stem ...
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Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model

Alvarez Laderas, Isabel; Ramos, Teresa L.; Medrano, Mayte; Caracuel García, Rocío; Barbado, María Victoria; Sánchez Hidalgo, Marina; Zamora, Rosario; Alarcón de la Lastra Romero, Catalina; Hidalgo, Francisco J.; Piruat, José Ignacio; Caballero Velázquez, Teresa; Pérez Simón, José Antonio (Elsevier, 2020)
Polyphenols are a group of chemical substances found in plants, with immunomodulatory, antiproliferative, and anti-inflammatory ...
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The role of TNFR2 and DR3 in the in vivo expansion of tregs in t cell depleting transplantation regimens

Rodriguez-Barbosa, Jose Ignacio; Schneider, Pascal; Graca, Luis; Bühler, Leo; Pérez Simón, José Antonio; Del Rio, Maria Luisa (MDPI, 2020)
Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and ...
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ASXL1 mutation as a surrogate marker in acute myeloid leukemia with myelodysplasia-related changes and normal karyotype

Prats-Martín, Concepción; Burillo-Sanz, Sergio; Morales-Camacho, Rosario M.; Pérez-López, Olga; Suito, Milagros; Vargas de los Monteros, María Teresa; Caballero Velázquez, Teresa; Pérez Simón, José Antonio (Wiley Open Access, 2020)
Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) are poor outcome leukemias. Its diagnosis is based ...
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Efficacy of bortezomib to intensify the conditioning regimen and the graft-versus-host disease prophylaxis for high-risk myeloma patients undergoing transplantation

Caballero Velázquez, Teresa; Calderón Cabrera, Cristina; López-Corral, L.; Puig, N.; Marquez-Malaver, F.; Pérez-López, E.; Pérez Simón, José Antonio (Springer Nature, 2020)
This multicenter phase I trial was designed to evaluate the safety and efficacy of bortezomib (Bz) as part of both the ...
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First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia

Salamero, Olga; Montesinos, Pau; Willekens, Christophe; Pérez Simón, José Antonio; Pigneux, Arnaud; Récher, Christian; Somervaille, Tim C.P. (American Society of Clinical Oncology, 2020)
PURPOSE Iadademstat is a novel, highly potent, and selective inhibitor of LSD1 (KDM1A), with preclinical in vitro and in ...
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Overcoming Chimeric Antigen Receptor (CAR) Modified T-Cell Therapy Limitations in Multiple Myeloma

García-Guerrero, Estefanía; Sierro-Martínez, Belén; Pérez Simón, José Antonio (Frontiers Media, 2020)
Multiple myeloma (MM) remains an incurable disease regardless of recent advances in the field. Therefore, a substantial ...
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Ruxolitinib in refractory acute and chronic graft-versus-host disease: a multicenter survey study

Escamilla Gómez, Virginia; García-Gutiérrez, Valentín; López Corral, Lucía; García Cadenas, Irene; Pérez Martínez, Ariadna; Márquez Malaver, Francisco J.; Caballero Velázquez, Teresa; Espigado Tocino, Ildefonso; Pérez Simón, José Antonio (Springer Nature, 2020)
Graft-versus-host disease is the main cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. ...
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Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications

Medrano, Mayte; Carrillo-Cruz, Estrella; Montero, Isabel; Pérez Simón, José Antonio (MDPI, 2018)
Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It plays a main role in the calcium ...
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RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation

Buchrieser, Julian; Oliva Martín, María José; Moore, Michael D.; Long, Joshua C. D.; Cowley, Sally A.; Long, Joshua C. D.; Pérez Simón, José Antonio; Venero Recio, José Luis (Springer Nature, 2018)
In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate ...
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Reduced intensity conditioning increases risk of severe cGVHD: identification of risk factors for cGVHD in a multicenter setting

Afram, Gabriel; Pérez Simón, José Antonio; Remberger, Mats; Caballero Velázquez, Teresa; Martino, Rodrigo; Piñana, Jose Luis; Ringden, Olle; Esquirol, Albert; Lopez-Corral, Lucia; Hägglund, Hans (Springer, 2018)
Chronic graft-versus-host disease (cGVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic ...
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Selection of Tumor-Specific Cytotoxic T Lymphocytes in Acute Myeloid Leukemia Patients Through the Identification of T-Cells Capable to Establish Stable Interactions With the Leukemic Cells: “Doublet Technology”

García Guerrero, Estefanía; Sánchez Abarca, Luis Ignacio; Domingo, Esther; Ramos, Teresa L.; Bejarano García, José Antonio; González Campos, José; Caballero Velázquez, Teresa; Pérez Simón, José Antonio (Frontiers Media, S.A., 2018)
The relevance of the immune system in cancer has long been studied. Autologous adoptive T cell therapies, based on the use ...
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IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q-AML

Lopez-Millan, Belen; Diaz de la Guardia, Rafael; Roca-Ho, Heleia; Anguita, Eduardo; Islam, Abul B.M.M.K.; Romero-Moya, Damia; Pérez Simón, José Antonio; Menendez, Pablo (Taylor & Francis, 2018)
Treatment for acute myeloid leukemia (AML) remains suboptimal and many patients remain refractory or relapse upon standard ...
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Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation

Rodriguez-Barbosa, J. I.; Ferreras, M. C.; Buhler, L.; Jones, N. D.; Schneider, P.; Pérez Simón, José Antonio; del Rio, M. L. (Taylor & Francis, 2018)
Natural killer (NK) cells are a population of innate type I lymphoid cells essential for early anti-viral responses and ...
PhD Thesis
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Nuevas modalidades de inmunoprofilaxis en trasplante: Inhibidores del proteosoma

Calderón Cabrera, Cristina; Pérez Simón, José Antonio; Caballero Velázquez, Teresa (2017)
El trasplante alogénico de progenitores hematopoyéticos es una opción potencialmente curativa para numerosos pacientes con ...
PhD Thesis
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Strategies to obtain tumor-reactive cells for cancer immunotherapy by cell sorting and genetic modifications of T lymphocytes.

García Guerrero, Estefanía; Pérez Simón, José Antonio; Hudecek, Michael (2017)
Los recientes avances en el campo de la inmunoterapia contra el cáncer han hecho posible que dicha técnica se convierta ...
PhD Thesis
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Nuevas estrategias y mecanismos de inmunomodulación en el tratamiento de las hemopatías malignas.

Álvarez Laderas, Isabel; Pérez Simón, José Antonio; Caballero Velázquez, Teresa (2017)
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Compassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis

Maldonado, Mauricio Sarmiento; Ramírez Villanueva, Pablo; Bertín Cortes-Monroy, Pablo; Jara Arias, Veronica; Soto Donoso, Katherine; Uribe Gonzalez, Pablo; Ocqueteau Tachini, Mauricio; Pérez Simón, José Antonio (BioMed Central, 2017)
Background: Ruxolitinib is a potent inhibitor of JAK1/2 with proven efcacy in myelofbrosis. In recent years, research in ...
PhD Thesis
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Nuevos fármacos en hemopatía aguda maligna: antagonistas del receptor NK-1 en leucemia aguda mieloblástica

Molinos Quintana, Águeda; Pérez Simón, José Antonio; Muñoz Sáez, Miguel (2016)
PhD Thesis
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Efecto inmunomodulador de la vitamina D en el periodo postrasplante alogénico de progenitores hematopoyéticos

Montero Cuadrado, María Isabel; Pérez Simón, José Antonio; Caballero Velázquez, Teresa (2016)
El presente trabajo de tesis se basa en un ensayo clínico multicéntrico realizado a nivel nacional sobre una población de ...
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Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion

Bejarano García, José Antonio; Millán-Uclés, África; Valle Rosado, Iván; Sánchez Abarca, Luis Ignacio; Caballero Velázquez, Teresa; Durán Galván, María José; Pérez Simón, José Antonio; Piraut Palomo, José Ignacio (2016)
It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to ...
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The Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor

García Guerrero, Estefanía; Pérez Simón, José Antonio; Sánchez Abarca, Luis Ignacio; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la; Díaz Quintana, Antonio Jesús (Public Library of Science, 2016)
Generating the immune response requires the discrimination of peptides presented by the human leukocyte antigen complex ...
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Multivariable time-dependent analysis of the impact of azacitidine in patients with lower-risk myelodysplastic syndrome and unfavorable specific lower-risk score

Falantes, José F.; García Delgado, Regina; Calderón Cabrera, Cristina; Márquez Malaver, Francisco J.; Valcárcel, D.; De Miguel, Dunia; Bailén, Alicia; Bargay, Joan; Bernal, Teresa; González Porras, José R.; Tormo, Mar; Ramos, Fernando; Andreu, Rafael; Xicoy, Blanca; Nomdedeu, Benet; Brunet, Salut; Sánchez, Joaquín; Fernández Jurado, Antonio; Bonabad, Santiago; Pérez Simón, José Antonio; Sanz, Guillermo (Elsevier, 2015)
Scoring systems for lower-risk myelodysplastic syndrome (LR-MDS) recognize patients with a poorer than expected outcome. ...
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Human Bone Marrow Stromal Cells Differentiate Into Corneal Tissue and Prevent Ocular Graft-Versus-Host Disease in Mice

Sánchez Abarca, Luis Ignacio; Hernández Galilea, Emiliano; Lorenzo, Rebeca; Herrero, Carmen; Verlasco, Almudena; Carrancio, Soraya; Caballero Velázquez, Teresa; Rodríguez Barbosa, José Ignacio; Parrilla, Marta; Del Cañizo, Consuelo; San Miguel, Jesús; Aijón, José; Pérez Simón, José Antonio (SAGE Journals, 2015)
Clinical trials have assessed the use of human bone marrow stromal cells (hBMSCs) for the treatment of immune-related ...
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Panobinostat as part of induction and maintenance for elderly patients with newly diagnosed acute myeloid leukemia: phase Ib/II panobidara study

Ocio, Enrique M.; Herrera, Pilar; Olave, María Teresa; Castro, Nerea; Pérez Simón, José Antonio; Brunet, Salut; Oriol, Albert; San Miguel, Jesús F. (Ferrata Storti Foundation, 2015)
This phase Ib/II trial combined the pan-deacetylase inhibitor panobinostat with chemotherapy followed by panobinostat ...
Article
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PTPN13 and beta-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche

López-Ruano, Guillermo; Prieto-Bermejo, Rodrigo; Ramos, Teresa L.; San-Segundo, Laura; Sánchez-Abarca, Luis Ignacio; Sánchez-Guijo, Fermín; Pérez Simón, José Antonio; Hernández-Hernández, Ángel (Elsevier, 2015)
The regulation of hematopoietic stem cells (HSCs) depends on the integration of the multiple signals received from the ...
PhD Thesis
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Cambios en los perfiles de expresión génica en condiciones fisiológicas versus patológicas en el sistema hematopoyético

Báez Palomo, Alicia; Pérez Simón, José Antonio; Urbano Ispizua, Álvaro (2014)
El trabajo realizado en esta tesis doctoral consiste en el estudio de los cambios en la expresión génica que sufren las ...
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An Active Isodicentric X Chromosome in a Case of Refractory Anaemia with Ring Sideroblasts Associated with Marked Thrombocytosis

Morales Camacho, Rosario María; Sánchez, Javier; Marcos Luque, Irene; Bernal, Ricardo; Falantes, José F.; Pérez Simón, José Antonio (Hindawi, 2014)
Refractory anaemia with ring sideroblasts and marked thrombocytosis (RARS-T) is a provisional entity in the World Health ...
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A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction

Díaz Castro, Blanca; García Flores, Gloria Paula; Báez Palomo, Alicia; Millán Uclés, África; Pérez Simón, José Antonio; Piruat Palomo, José Ignacio; López Barneo, José (2014)
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The Granulocyte colony-stimulating factor produces long-term changes on gene and miRNA expression profiles in CD34+ cells from healthy donors

Urbano Ispizua, Álvaro; Prats Martín, Concepción; Álvarez Laderas, Isabel; Barbado González, Mª Victoria; Carmona González, Magdalena; Pérez Simón, José Antonio; Báez Palomo, Alicia; Martín Antonio, Beatriz; Piruat Palomo, José Ignacio (2014)
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Differential cytogenetic profile in advanced chronic myeloid leukemia with sequential lymphoblastic and myeloblastic blast crisis

Calderón Cabrera, Cristina; Montero, I.; Morales, R. M.; Sánchez, J.; Carrillo, E.; Caballero Velázquez, Teresa; Prats, C.; Bernal, R.; De Blas, J. M.; Pérez Simón, José Antonio (Elsevier, 2013)
Frequency of additional chromosomal abnormalities in chronic myeloid leukemia (CML) is estimated to be 7% in chronic phase ...
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The combination of sirolimus plus tacrolimus improves outcome after reduced-intensity conditioning, unrelated donor hematopoietic stem cell transplantation compared with cyclosporine plus mycofenolate

Pérez Simón, José Antonio; Martino, Rodrigo; Parody, Rocío; Cabrero, Mónica; López Corral, Lucía; Valcárcel, D.; Martínez, Carmen; Solano, Carlos; Vázquez, Lourdes; Márquez Malaver, Francisco J.; Sierra, Jordi; Caballero, Dolores (Ferrata Storti Foundation, 2013)
Different types of graft-versus-host disease prophylaxis have been proposed in the setting of reduced intensity and ...
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The novel combination of sirolimus and bortezomib prevents graft-versus-host disease but maintains the graft-versus-leukemia effect after allogeneic transplantation

Caballero Velázquez, Teresa; Sánchez-Abarca, Luis Ignacio; Gutiérrez-Cosío, Silvia; Blanco, Belén; Calderón, Cristina; Herrero, Carmen; Carrancio, Soraya; Serrano, Concepción; del Cañizo, Consuelo; San Miguel, Jesús F.; Pérez Simón, José Antonio (Ferrata Storti Foundation, 2012)
Background We have previously shown that bortezomib induces a depletion of alloreactive T cells and allows the expansion ...
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Evaluation of prognostic factors among patients with chronic graft-versus-host disease

Pérez Simón, José Antonio; Afram, Gabriel; Martino, Rodrigo; Piñana, José L.; Caballero Velázquez, Teresa; Ringden, Olle; Valcárcel, D.; Caballero, Dolores; Remberger, Mats; De Paz, Yanira; Sierra, Jordi; San Miguel, Jesús; Hagglund, Hans;  (Ferrata-Storti Foundation, 2011)
Background: Chronic graft-versus-host disease (cGVHD) is a major complication after allogeneic stem cell transplantation ...
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Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial

Pérez Simón, José Antonio; López-Villar, Olga; Andreu, Enrique J.; Rifón, José; Muntion, Sandra; Campelo, María Diez; Sánchez-Guijo, Fermín; Martinez, Carmen; Valcarcel, David; Del Cañizo, Consuelo (2011)
This trial evaluated the feasibility and efficacy of the infusion of mesenchymal stem cells expanded using human serum for ...