Artículo
MUFAs in High-Fat Diets Protect against Obesity-Induced Bias of Hematopoietic Cell Lineages
Autor/es | Lemus Conejo, Ana
Medrano, Mayte López Martín, Sergio Millán-Linares, María del Carmen Rosillo Ramírez, María de los Ángeles Pérez Simón, José Antonio Muriana, Francisco J. G. Abia González, María del Rocío |
Departamento | Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-02-14 |
Publicado en |
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Resumen | Scope: The role of dietary fatty acids in the generation of bone marrow (BM) immune cells and their trafficking to extramedullary compartments in the obesity is not yet fully understood.
Methods and Results: C57BL/6J mice ... Scope: The role of dietary fatty acids in the generation of bone marrow (BM) immune cells and their trafficking to extramedullary compartments in the obesity is not yet fully understood. Methods and Results: C57BL/6J mice are randomly assigned to isocaloric high-fat diets (HFDs) formulate with dietary fats rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs fortified with eicosapentaenoic and docosahexaenoic acids for 20 weeks, followed by profiling of the obese metabolic phenotype and immunophenotypic features of immune cells in blood, spleen, and BM. All HFDs induce an obese phenotype, but it becomes largely less disruptive after the HFDs are enriched in MUFAs, which also induce signs of granulopoiesis and an expansion of long-term hematopoietic stem and granulocyte-macrophage progenitor cells in BM. In contrast, a HFD enriched in SFAs disturbs the fitness of medullary lymphocytes and promotes monopoiesis in favor of pro-inflammatory activated subsets. Conclusion: The reshaping of the fatty acid pools with MUFAs from the diet serves to manipulate the generation and trafficking of immune cells that are biased during obesity. These findings reveal a novel strategy by which dietary MUFAs may be instrumental in combating HFD-induced dysfunctional immune systems. |
Agencias financiadoras | Ministerio de Ciencia, Innovación y Universidades (MICINN). España |
Identificador del proyecto | AGL2016-80852-R |
Cita | Lemus Conejo, A., Medrano, M., López Martín, S., Millán Linares, M.C., Rosillo Ramírez, M.d.l.Á., Pérez Simón, J.A.,...,Abia González, M.d.R. (2021). MUFAs in High-Fat Diets Protect against Obesity-Induced Bias of Hematopoietic Cell Lineages. Molecular Nutrition & Food Research, 65, 2001203. https://doi.org/10.1002/mnfr.202001203. |
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