Artículo
Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model
Autor/es | Alvarez Laderas, Isabel
Ramos, Teresa L. Medrano, Mayte Caracuel García, Rocío Barbado, María Victoria Sánchez Hidalgo, Marina ![]() ![]() ![]() ![]() ![]() ![]() ![]() Zamora, Rosario Alarcón de la Lastra Romero, Catalina ![]() ![]() ![]() ![]() ![]() ![]() ![]() Hidalgo, Francisco J. Piruat, José Ignacio Caballero Velázquez, Teresa ![]() ![]() ![]() ![]() ![]() Pérez Simón, José Antonio ![]() ![]() ![]() ![]() ![]() |
Departamento | Universidad de Sevilla. Departamento de Farmacología |
Fecha de publicación | 2020 |
Fecha de depósito | 2021-12-27 |
Publicado en |
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Resumen | Polyphenols are a group of chemical substances found in plants, with immunomodulatory, antiproliferative, and anti-inflammatory properties that might be useful in the prophylaxis and treatment of graft-versus-host disease ... Polyphenols are a group of chemical substances found in plants, with immunomodulatory, antiproliferative, and anti-inflammatory properties that might be useful in the prophylaxis and treatment of graft-versus-host disease (GVHD). Polyphenolic extract (PE) obtained from extra virgin olive oil (EVOO) decreased the activation and proliferation of activated T cells. In addition, a decreased production of proinflammatory cytokines was observed upon exposure to PE. Western blot assays showed a marked inhibition of Akt phosphorylation and nuclear translocation of NF-κB in activated T cells. In a murine model of acute GVHD, we observed that mice that received a diet supplemented in PE (600 ppm) presented a higher survival rate and lower risk of developing GVHD when compared with the group that received a control diet. Histopathologic examination showed a significantly lower gut involvement in mice receiving PE, with a decrease in proinflammatory cytokines (IL-2, IL-17, and TNF-α) in serum and the reestablishment of butyrate concentration in the gut. In conclusion, PE obtained from EVOO exerted a potent immunomodulatory effect, reducing the activation and proliferation of activated T cells and the production of proinflammatory cytokines. In a murine model of acute GVHD, a PE-supplemented diet reduced the incidence and severity of the disease and increased survival after transplantation. |
Cita | Alvarez Laderas, I., Ramos, T.L., Medrano, M., Caracuel García, R., Barbado, M.V., Sánchez Hidalgo, M.,...,Pérez Simón, J.A. (2020). Polyphenolic Extract (PE) from Olive Oil Exerts a Potent Immunomodulatory Effect and Prevents Graft-versus-Host Disease in a Mouse Model. Biology of Blood and Marrow Transplantation, 26 (4), 615-624. |
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