Artículo
Multivariable time-dependent analysis of the impact of azacitidine in patients with lower-risk myelodysplastic syndrome and unfavorable specific lower-risk score
Autor/es | Falantes, José F.
García Delgado, Regina Calderón Cabrera, Cristina Márquez Malaver, Francisco J. Valcárcel, D. De Miguel, Dunia Bailén, Alicia Bargay, Joan Bernal, Teresa González Porras, José R. Tormo, Mar Ramos, Fernando Andreu, Rafael Xicoy, Blanca Nomdedeu, Benet Brunet, Salut Sánchez, Joaquín Fernández Jurado, Antonio Bonabad, Santiago Pérez Simón, José Antonio Sanz, Guillermo |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2015 |
Fecha de depósito | 2022-02-11 |
Publicado en |
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Resumen | Scoring systems for lower-risk myelodysplastic syndrome (LR-MDS) recognize patients with a poorer than expected outcome. This study retrospectively analyzes the role of azacitidine in LR-MDS with adverse risk score and ... Scoring systems for lower-risk myelodysplastic syndrome (LR-MDS) recognize patients with a poorer than expected outcome. This study retrospectively analyzes the role of azacitidine in LR-MDS with adverse risk score and compared to an historical cohort treated with best supportive care or erythropoiesis-stimulating agents. Overall response to AZA was 40%. One and 2-year probabilities of survival were 62% and 45% for AZA vs. 25% and 11% (P=10(-4)). In a multivariable time-dependent analysis, response to AZA (CR/PR/HI) was associated with an improved survival (HR=0.234, 95% CI, 0.063-0.0863; P=0.029). Thrombocytopenia (<50 × 10(9)L(-1)) is confirmed as an adverse parameter in LR-MDS (HR=1.649, 95% CI, 1.012-2.687; P=0.045). |
Cita | Falantes, J.F., García Delgado, R., Calderón Cabrera, C., Márquez Malaver, F.J., Valcárcel, D., De Miguel, D.,...,Sanz, G. (2015). Multivariable time-dependent analysis of the impact of azacitidine in patients with lower-risk myelodysplastic syndrome and unfavorable specific lower-risk score. Leukemia Research, 39 (1), 52-57. |
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