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dc.creatorÁlvarez-Amor, Leticiaes
dc.creatorLuque Sierra, Amparoes
dc.creatorCárdenas, Antonioes
dc.creatorLópez-Bermudo, Lucíaes
dc.creatorLópez-Beas, Javieres
dc.creatorAndújar, Eloísaes
dc.creatorVarela Pérez, Lourdes Maríaes
dc.creatorRomero Gómez, Manueles
dc.creatorMartín, Franzes
dc.date.accessioned2022-10-24T13:55:52Z
dc.date.available2022-10-24T13:55:52Z
dc.date.issued2021
dc.identifier.citationÁlvarez-Amor, L., Luque Sierra, A., Cárdenas, A., López-Bermudo, L., López-Beas, J., Andújar, E.,...,Martín, F. (2021). Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr−/−.Leiden mice without attenuation of steatohepatitis. Scientific reports, 11 (1), 8250. https://doi.org/10.1038/s41598-021-87761-3.
dc.identifier.issn2045-2322es
dc.identifier.urihttps://hdl.handle.net/11441/138278
dc.description.abstractDietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic fatty liver disease (NAFLD), which is associated with insulin resistance (IR). Fatty acid composition is critical for IR and subsequent NAFLD development. Extra-virgin olive oil (EVOO) is the main source of monounsaturated fatty acids (MUFA) in Mediterranean diets. This study examined whether EVOO containing high fat diets may prevent diet-induced NAFLD using Ldlr−/−. Leiden mice. In female Ldlr−/−.Leiden mice, the efects of the following high fat diets (HFDs) were examined: a lard-based HFD (HFD-L); an EVOO-based HFD (HFD-EVOO); a phenolic compounds-rich EVOO HFD (HFD-OL). We studied changes in body weight (BW), lipid profle, transaminases, glucose homeostasis, liver pathology and transcriptome. Both EVOO diets reduced body weight (BW) and improved insulin sensitivity. The EVOOs did not improve transaminase values and increased LDL-cholesterol and liver collagen content. EVOOs and HFD-L groups had comparable liver steatosis. The profbrotic efects were substantiated by an up-regulation of gene transcripts related to glutathione metabolism, chemokine signaling and NF-kappa-B activation and down-regulation of genes relevant for fatty acid metabolism. Collectivelly, EVOO intake improved weight gain and insulin sensitivity but not liver infammation and fbrosis, which was supported by changes in hepatic genes expression.es
dc.formatapplication/pdfes
dc.format.extent16 p.es
dc.language.isoenges
dc.publisherNature Publishing Groupes
dc.relation.ispartofScientific reports, 11 (1), 8250.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleExtra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr−/−.Leiden mice without attenuation of steatohepatitises
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.projectIDPAI-BIO311es
dc.relation.projectIDCB07/08/0006es
dc.relation.projectIDAGL2014-54585-Res
dc.relation.projectIDAGL2017-86927-Res
dc.relation.projectIDCP14/00105es
dc.relation.projectIDPI18/01590es
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-021-87761-3es
dc.identifier.doi10.1038/s41598-021-87761-3es
dc.journaltitleScientific reportses
dc.publication.volumen11es
dc.publication.issue1es
dc.publication.initialPage8250es
dc.contributor.funderConsejeria de Economia, Innovacion, Ciencia y Empleo, Junta de Andaluciaes
dc.contributor.funderInstituto de Salud Carlos IIIes
dc.contributor.funderMinisterio de Economia, Industria y Competitividad, Gobierno de Espanaes

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