Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
Batchelor, Hannah Katharine
Bernkop Schnürch, Andreas
Meléndez Martínez, Antonio Jesús
|Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal
|Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient ...
Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
|European Cooperation in Science and Technology (COST)
National Centre for Research and Development
Ministry of Education, Youth and Sports of the Czech Republic
Czech Science Foundation