dc.creator | Sánchez Varo, Raquel María | es |
dc.creator | Mejías Ortega, Marina | es |
dc.creator | Fernández Valenzuela, Juan José | es |
dc.creator | Núñez Díaz, Cristina | es |
dc.creator | Cáceres Palomo, Laura | es |
dc.creator | Vegas Gómez, Laura | es |
dc.creator | Sánchez Mejías, Elisabeth | es |
dc.creator | Trujillo Estrada, Laura Isabel | es |
dc.creator | García León, Juan Antonio | es |
dc.creator | Moreno González, Inés | es |
dc.creator | Vizuete Chacón, María Luisa | es |
dc.creator | Vitorica Ferrández, Francisco Javier | es |
dc.creator | Baglietto Vargas, David | es |
dc.creator | Gutiérrez Pérez, Antonia | es |
dc.date.accessioned | 2022-05-27T16:20:34Z | |
dc.date.available | 2022-05-27T16:20:34Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Sánchez Varo, R.M., Mejías Ortega, M., Fernández Valenzuela, J.J., Núñez Díaz, C., Cáceres Palomo, L., Vegas Gómez, L.,...,Gutiérrez Pérez, A. (2022). Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis. International Journal of Molecular Sciences, 23 (10), 5404. | |
dc.identifier.issn | 1661-6596 | es |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/133812 | |
dc.description.abstract | Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations in amyloid precursor protein (APP) and presenilins (PS) genes. However, due to the repeated failure of translational applications from animal models to human patients, along with the recent advances in genetic susceptibility and our current understanding on disease biology, these models have evolved over time in an attempt to better reproduce the complexity of this devastating disease and improve their applicability. In this review, we provide a comprehensive overview about the major pathological elements of human AD (plaques, tauopathy, synaptic damage, neuronal death, neuroinflammation and glial dysfunction), discussing the knowledge that available mouse models have provided about the mechanisms underlying human disease. Moreover, we highlight the pros and cons of current models, and the revolution offered by the concomitant use of transgenic mice and omics technologies that may lead to a more rapid improvement of the present modeling battery. | es |
dc.description.sponsorship | Instituto de Salud Carlos III PI21/00915, PI21/00914 | es |
dc.description.sponsorship | Junta de Andalucía UMA18-FEDERJA-211, UMA20-FEDERJA-104, P18-RT-2233, US-1262734, PI-0276-2018 | es |
dc.description.sponsorship | Alzheimer Association AARG-22-928219 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID2019-108911RA-100, PID2019-107090RA-100 | es |
dc.description.sponsorship | Universidad de Málaga B1-2019_07, B1-2020_04, B1-2019_06 | es |
dc.format | application/pdf | es |
dc.format.extent | 46 p. | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es |
dc.relation.ispartof | International Journal of Molecular Sciences, 23 (10), 5404. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Alzheimer’s disease | es |
dc.subject | Amyloid | es |
dc.subject | Astrocytes | es |
dc.subject | Microglia | es |
dc.subject | Neurodegeneration | es |
dc.subject | Oligodendrocytes | es |
dc.subject | Tau | es |
dc.subject | Transgenic mice | es |
dc.title | Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.projectID | PI21/00915 | es |
dc.relation.projectID | PI21/00914 | es |
dc.relation.projectID | UMA18-FEDERJA-211 | es |
dc.relation.projectID | UMA20-FEDERJA-104 | es |
dc.relation.projectID | P18-RT-2233 | es |
dc.relation.projectID | US-1262734 | es |
dc.relation.projectID | PI-0276-2018 | es |
dc.relation.projectID | AARG-22-928219 | es |
dc.relation.projectID | PID2019-108911RA-100 | es |
dc.relation.projectID | PID2019-107090RA-100 | es |
dc.relation.projectID | B1-2019_07 | es |
dc.relation.projectID | B1-2020_04 | es |
dc.relation.projectID | B1-2019_06 | es |
dc.relation.publisherversion | https://doi.org/10.3390/ijms23105404 | es |
dc.identifier.doi | 10.3390/ijms23105404 | es |
dc.journaltitle | International Journal of Molecular Sciences | es |
dc.publication.volumen | 23 | es |
dc.publication.issue | 10 | es |
dc.publication.initialPage | 5404 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Alzheimer Association | es |
dc.contributor.funder | Universidad de Málaga | es |