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dc.creatorRosillo Ramírez, María de los Ángeleses
dc.creatorMontserrat de la Paz, Sergioes
dc.creatorAbia González, María del Rocíoes
dc.creatorCastejón Martínez, María Luisaes
dc.creatorMillán-Linares, María del Carmenes
dc.creatorAlarcón de la Lastra Romero, Catalinaes
dc.creatorFernández-Bolaños Guzmán, José Maríaes
dc.creatorMuriana, Francisco J. G.es
dc.date.accessioned2022-03-23T11:34:57Z
dc.date.available2022-03-23T11:34:57Z
dc.date.issued2020
dc.identifier.citationRosillo Ramírez, M.d.l.Á., Montserrat de la Paz, S., Abia González, M.d.R., Castejón Martínez, M.L., Millán Linares, M.C., Alarcón de la Lastra Romero, C.,...,Muriana, F.J.G. (2020). Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function. Food and Function, 11 (5), 4038-4048. https://doi.org/10.1039/D0FO00433B.
dc.identifier.issn2042-6496es
dc.identifier.issn2042-650Xes
dc.identifier.urihttps://hdl.handle.net/11441/131179
dc.description.abstractDuring chronic inflammation, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) have well established effects on gene networks that stimulate osteoclastogenesis, which is the culprit of several bone diseases. In this study, we investigated the anti-osteoclastogenic effects in vitro of oleuropein (OL) and its peracetylated derivative (Per-OL) by exploring the expression level of key hub genes involved in fate decision and lineage commitment, differentiation, and function of human blood monocyte-derived osteoclasts. Monocytes were purified from peripheral blood mononuclear cells of healthy individuals using commercial antibodies coated with magnetic beads and treated with M-CSF/RANKL in the presence or absence of OL or Per-OL (25 and 50 μM) for 6 days. We demonstrated that OL and especially Per-OL impair transcriptional gene circuits able to support osteoclastogenesis from human blood monocytes. Our results indicate that OL and notably Per-OL are promising candidates to control osteoclastogenesis.es
dc.formatapplication/pdfes
dc.format.extent11 p.es
dc.language.isoenges
dc.publisherRoyal Society of Chemistryes
dc.relation.ispartofFood and Function, 11 (5), 4038-4048.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleOleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and functiones
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química orgánicaes
dc.relation.publisherversionDOI https://doi.org/10.1039/D0FO00433Bes
dc.identifier.doi10.1039/D0FO00433Bes
dc.journaltitleFood and Functiones
dc.publication.volumen11es
dc.publication.issue5es
dc.publication.initialPage4038es
dc.publication.endPage4048es

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional