dc.creator | Díez-Quijada Jiménez, Leticia | es |
dc.creator | Casas Rodríguez, Antonio | es |
dc.creator | Guzmán Guillén, Remedios | es |
dc.creator | Molina Hernández, Verónica | es |
dc.creator | González Albaladejo, Rafael | es |
dc.creator | Cameán Fernández, Ana María | es |
dc.creator | Jos Gallego, Ángeles Mencía | es |
dc.date.accessioned | 2022-03-16T16:42:15Z | |
dc.date.available | 2022-03-16T16:42:15Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Díez-Quijada Jiménez, L., Casas Rodríguez, A., Guzmán Guillén, R., Molina Hernández, V., González Albaladejo, R., Cameán Fernández, A.M. y Jos Gallego, Á.M. (2022). Immunomodulatory Effects of Pure Cylindrospermopsin in Rats Orally Exposed for 28 Days. Toxins, 14 (2), 144. | |
dc.identifier.issn | 2072-6651 | es |
dc.identifier.uri | https://hdl.handle.net/11441/130889 | |
dc.description.abstract | Cylindrospermopsin (CYN) is a ubiquitous cyanotoxin showing increasing incidence worldwide. CYN has been classified as a cytotoxin and, among its toxic effects, its immunotoxicity is scarcely studied. This work investigates for the first time the influence of oral CYN exposure (18.75; 37.5 and 75 µg/kg b.w./day, for 28 days) on the mRNA expression of selected interleukin (IL) genes (IL-1β, IL-2, IL-6, Tumor Necrosis Factor alpha (TNF-α), Interferon gamma (IFN-γ)) in the thymus and the spleen of male and female rats, by quantitative real-time polymerase chain reaction (RT-qPCR). Moreover, their serum levels were also measured by a multiplex-bead-based immunoassay, and a histopathological study was performed. CYN produced immunomodulation mainly in the thymus of rats exposed to 75 µg CYN/kg b.w./day in both sexes. However, in the spleen only IL-1β and IL-2 (males), and TNF-α and IFN-γ (females) expression was modified after CYN exposure. Only female rats exposed to 18.75 µg CYN/kg b.w./day showed a significant decrease in TNF-α serum levels. There were no significant differences in the weight or histopathology in the organs studied. Further research is needed to obtain a deeper view of the molecular mechanisms involved in CYN immunotoxicity and its consequences on long-term exposures. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID2019-104890RB-I00, 10.13039/ 501100011033 | es |
dc.format | application/pdf | es |
dc.format.extent | 18 p. | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es |
dc.relation.ispartof | Toxins, 14 (2), 144. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cylindrospermopsin | es |
dc.subject | Immunotoxicity | es |
dc.subject | MRNA expression | es |
dc.subject | Rats | es |
dc.subject | Spleen | es |
dc.subject | Thymus | es |
dc.title | Immunomodulatory Effects of Pure Cylindrospermopsin in Rats Orally Exposed for 28 Days | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Biología Vegetal y Ecología | es |
dc.relation.projectID | PID2019-104890RB-I00 | es |
dc.relation.projectID | 10.13039/ 501100011033 | es |
dc.relation.publisherversion | https://doi.org/10.3390/toxins14020144 | es |
dc.identifier.doi | 10.3390/toxins14020144 | es |
dc.journaltitle | Toxins | es |
dc.publication.volumen | 14 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 144 | es |