Artículo
Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast
Autor/es | Jaafar, Mariam
Contreras Fernández, Julia Mª Dominique, Carine Martín Villanueva, Sara Capeyrou, Régine Vitali, Patrice Rodríguez Galán, Olga Velasco Ramírez, María del Carmen Humbert, Odile Watkins, Nicholas J. Villalobo Polo, Eduardo Bohnsack, Katherine E. Cruz Díaz, Jesús de la Henras, Anthony K. |
Departamento | Universidad de Sevilla. Departamento de Genética Universidad de Sevilla. Departamento de Microbiología |
Fecha de publicación | 2021 |
Fecha de depósito | 2021-11-08 |
Publicado en |
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Resumen | Synthesis of eukaryotic ribosomes involves the assembly and maturation of precursor particles (pre-ribosomal particles) containing ribosomal RNA (rRNA) precursors, ribosomal proteins (RPs) and a plethora of assembly factors ... Synthesis of eukaryotic ribosomes involves the assembly and maturation of precursor particles (pre-ribosomal particles) containing ribosomal RNA (rRNA) precursors, ribosomal proteins (RPs) and a plethora of assembly factors (AFs). Formation of the earliest precursors of the 60S ribosomal subunit (pre-60S r-particle) is among the least understood stages of ribosome biogenesis. It involves the Npa1 complex, a protein module suggested to play a key role in the early structuring of the pre-rRNA. Npa1 displays genetic interactions with the DExD-box protein Dbp7 and interacts physically with the snR190 box C/D snoRNA. We show here that snR190 functions as a snoRNA chaperone, which likely cooperates with the Npa1 complex to initiate compaction of the pre-rRNA in early pre-60S r-particles. We further show that Dbp7 regulates the dynamic base-pairing between snR190 and the pre-rRNA within the earliest pre-60S r-particles, thereby participating in structuring the peptidyl transferase center (PTC) of the large ribosomal subunit. |
Identificador del proyecto | PID2019-103859-GB-I00
AEI/ 10.13039/501100011033 SFB860 |
Cita | Jaafar, M., Contreras Fernández, J.M., Dominique, C., Martín Villanueva, S., Capeyrou, R., Vitali, P.,...,Henras, A.K. (2021). Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast. Nature Communications, 12 (1), 6153. |
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