dc.creator | Jaafar, Mariam | es |
dc.creator | Contreras Fernández, Julia Mª | es |
dc.creator | Dominique, Carine | es |
dc.creator | Martín Villanueva, Sara | es |
dc.creator | Capeyrou, Régine | es |
dc.creator | Vitali, Patrice | es |
dc.creator | Rodríguez Galán, Olga | es |
dc.creator | Velasco Ramírez, María del Carmen | es |
dc.creator | Humbert, Odile | es |
dc.creator | Watkins, Nicholas J. | es |
dc.creator | Villalobo Polo, Eduardo | es |
dc.creator | Bohnsack, Katherine E. | es |
dc.creator | Cruz Díaz, Jesús de la | es |
dc.creator | Henras, Anthony K. | es |
dc.date.accessioned | 2021-11-08T16:40:42Z | |
dc.date.available | 2021-11-08T16:40:42Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Jaafar, M., Contreras Fernández, J.M., Dominique, C., Martín Villanueva, S., Capeyrou, R., Vitali, P.,...,Henras, A.K. (2021). Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast. Nature Communications, 12 (1), 6153. | |
dc.identifier.issn | 2041-1723 | es |
dc.identifier.uri | https://hdl.handle.net/11441/127175 | |
dc.description.abstract | Synthesis of eukaryotic ribosomes involves the assembly and maturation of precursor particles (pre-ribosomal particles) containing ribosomal RNA (rRNA) precursors, ribosomal proteins (RPs) and a plethora of assembly factors (AFs). Formation of the earliest precursors of the 60S ribosomal subunit (pre-60S r-particle) is among the least understood stages of ribosome biogenesis. It involves the Npa1 complex, a protein module suggested to play a key role in the early structuring of the pre-rRNA. Npa1 displays genetic interactions with the DExD-box protein Dbp7 and interacts physically with the snR190 box C/D snoRNA. We show here that snR190 functions as a snoRNA chaperone, which likely cooperates with the Npa1 complex to initiate compaction of the pre-rRNA in early pre-60S r-particles. We further show that Dbp7 regulates the dynamic base-pairing between snR190 and the pre-rRNA within the earliest pre-60S r-particles, thereby participating in structuring the peptidyl transferase center (PTC) of the large ribosomal subunit. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID2019-103859-GB-I00, AEI/ 10.13039/501100011033 | es |
dc.description.sponsorship | Deutsche Forschungsgemeinschaft SFB860 | es |
dc.format | application/pdf | es |
dc.format.extent | 17 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer Nature | es |
dc.relation.ispartof | Nature Communications, 12 (1), 6153. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
dc.relation.projectID | PID2019-103859-GB-I00 | es |
dc.relation.projectID | AEI/ 10.13039/501100011033 | es |
dc.relation.projectID | SFB860 | es |
dc.relation.publisherversion | https://doi.org/10.1038/s41467-021-26207-w | es |
dc.identifier.doi | 10.1038/s41467-021-26207-w | es |
dc.journaltitle | Nature Communications | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 6153 | es |