NameCruz Díaz, Jesús de la
DepartmentGenética
Knowledge areaGenética
Professional categoryCatedrático de Universidad
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PhD Thesis
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Molecular description of the role of protein synthesis in the cellular response to the treatment with the antitumoral drug Sorafenib in HCC lines

Contreras Bernal, Laura; Cruz Díaz, Jesús de la; Muntané Relat, Jordi (2023)
El carcinoma hepatocellular (CHC) es reconocido como el principal cáncer primario de hígado y uno de los cánceres con mayor ...
PhD Thesis
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eL15 and eL22 proteins and their functional environments during ribosome assembly in Saccharomyces cerevisiae

Fernández Fernández, José; Cruz Díaz, Jesús de la (2023)
Ribosomes are ribonucleoprotein complexes in charge of protein translation. Translation is an essential process in all ...
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The Terminal Extensions of Dbp7 Influence Growth and 60S Ribosomal Subunit Biogenesis in Saccharomyces cerevisiae

Contreras Fernández, Julia Mª; Ruiz Blanco, Óscar; Dominique, Carine; Humbert, Odile; Henry, Yves; Henras, Anthony K.; Cruz Díaz, Jesús de la; Villalobo Polo, Eduardo (Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Ribosome synthesis is a complex process that involves a large set of protein trans-acting factors, among them DEx(D/H)-box ...
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Broad Transcriptomic Impact of Sorafenib and Its Relation to the Antitumoral Properties in Liver Cancer Cells

Contreras Bernal, Laura; Rodríguez Gil, Alfonso; Muntané Relat, Jordi; Cruz Díaz, Jesús de la (Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Hepatocellular carcinoma (HCC) is one of the most frequent and essentially incurable cancers in its advanced stages. The ...
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Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation

Micic, Jelena; Rodríguez Galán, Olga; Babiano González, Reyes; Fitzgerald, Fiona; Fernández Fernández, José; Gao, Ning; Woolford, John L.; Cruz Díaz, Jesús de la (Oxford University Press, 2022)
During translation, nascent polypeptide chains travel from the peptidyl transferase center through the nascent polypeptide ...
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The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation

Rossler, Ingrid; Weigl, Sarah; Fernández Fernández, José; Martín Villanueva, Sara; Strauss, Daniela; Hurt, Ed; Cruz Díaz, Jesús de la; Pertschy, Brigitte (Taylor & Francis, 2022)
The small ribosomal subunit protein Rps15/uS19 is involved in early nucleolar ribosome biogenesis and subsequent nuclear ...
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A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae

Rodríguez Galán, Olga; García Gómez, Juan José; Valle Rosado, Iván; Wei, Wu; Méndez-Godoy, Alfonso; Pillet, Benjamin; Alekseenko, Alisa; Steinmetz, Lars M.; Pelechano, Vicent; Kressler, Dieter; Cruz Díaz, Jesús de la (Oxford University Press, 2021)
Proteostasis needs to be tightly controlled to meet the cellular demand for correctly de novo folded proteins and to avoid ...
Article
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Ubiquitin and Ubiquitin-Like Proteins and Domains in Ribosome Production and Function: Chance or Necessity?

Martín Villanueva, Sara; Gutiérrez Pozo, Gabriel; Kressler, Dieter; Cruz Díaz, Jesús de la (Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Ubiquitin is a small protein that is highly conserved throughout eukaryotes. It operates as a reversible post-translational ...
Article
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Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast

Jaafar, Mariam; Contreras Fernández, Julia Mª; Dominique, Carine; Martín Villanueva, Sara; Capeyrou, Régine; Vitali, Patrice; Rodríguez Galán, Olga; Velasco Ramírez, María del Carmen; Humbert, Odile; Watkins, Nicholas J.; Villalobo Polo, Eduardo; Bohnsack, Katherine E.; Cruz Díaz, Jesús de la; Henras, Anthony K. (Springer Nature, 2021)
Synthesis of eukaryotic ribosomes involves the assembly and maturation of precursor particles (pre-ribosomal particles) ...
PhD Thesis
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RNA Helicases in 60S Ribosomal Subunit Biogenesis in Saccharomyces cerevisiae

Contreras Fernández, Julia Mª; Villalobo Polo, Eduardo; Cruz Díaz, Jesús de la (2020)
The ribosomes are the cellular organelles responsible for translating messenger RNA (mRNA) to proteins. In eukaryotic ...
Article
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Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells

Navarro Villarán, Elena; Cruz Ojeda, Patricia de la; Contreras, Laura; González, Raul; Negrete, María; Rodríguez Hernández, María A.; Marín Gómez, Luis Miguel; Álamo Martínez, José M.; Calvo, Antonio; Gómez Bravo, Miguel Ángel; Cruz Díaz, Jesús de la; Padillo Ruiz, Francisco Javier; Muntané Relat, Jordi (1421-9778, 2020)
Background/Aims: Orthotopic liver transplantation (OLT) is the recommended treatment for patients at early stages of ...
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Overexpression of budding yeast protein phosphatase Ppz1 impairs translation

Calafí Pascual, Carlos Alberto; López Malo, María; Velázquez, Diego; Zhang, Chunyi; Fernández Fernández, José; Rodríguez Galán, Olga; Cruz Díaz, Jesús de la (Elsevier, 2020)
The Ser/Thr protein phosphatase Ppz1 from Saccharomyces cerevisiae is the best characterized member of a family of enzymes ...
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Prefoldin-like Bud27 influences the transcription of ribosomal components and ribosome biogenesis in Saccharomyces cerevisiae

Martínez Fernández, Verónica; Cuevas Bermúdez, Abel; Gutiérrez Santiago, Francisco; Garrido Godino, Ana Isabel; Rodríguez Galán, Olga; Jordán Pla, Antonio; Lois, Sergio; Triviño, Juan C.; Cruz Díaz, Jesús de la; Navarro, Francisco (Cold Spring Harbor Laboratory Press, 2020)
Understanding the functional connection that occurs for the three nuclear RNA polymerases to synthesize ribosome components ...
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The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes

Olombrada, Miriam; Pena, Cohue; Rodríguez Galán, Olga; Klingauf Nerurkar, Purnima; Portugal Calisto, Daniela; Oborska Oplová, Michaela; Altvater, Martín; Gavilanes, Jose G.; Martínez del Pozo, Álvaro; Cruz Díaz, Jesús de la (Oxford University Press, 2020)
The ribotoxin α-sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional ...
PhD Thesis
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Role of ribosomal proteins eL40 and eS12 in the biogenesis and function of yeast ribosomes

Martín Villanueva, Sara; Cruz Díaz, Jesús de la (2019)
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The Ubiquitin Moiety of Ubi1 Is Required for Productive Expression of Ribosomal Protein eL40 in Saccharomyces cerevisiae

Martín Villanueva, Sara; Fernández Pevida, Antonio; Kressler, Dieter; Cruz Díaz, Jesús de la (MDPI, 2019)
Ubiquitin is a highly conserved small eukaryotic protein. It is generated by proteolytic cleavage of precursor proteins ...
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Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae

Ramos Sáenz, Ana; González Álvarez, Daniel; Rodríguez Galán, Olga; Rodríguez Gil, Alfonso; Gaspar, Sonia G.; Villalobo Polo, Eduardo; Dosil, Mercedes; Cruz Díaz, Jesús de la (Cold Spring Harbor Laboratory Press, 2019)
In Saccharomyces cerevisiae, more than 250 trans-acting factors are involved in the maturation of 40S and 60S ribosomal ...
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Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells

Rodríguez Hernández, María A.; González, Raúl; Rosa, Ángel J. de la; Gallego, Paloma; Ordóñez, Raquel; Navarro Villarán, Elena; Contreras Bernal, Laura; Rodríguez Arribas, M.; Cruz Díaz, Jesús de la (Wiley-Blackwell, 2018)
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular ...
Article
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Ribosomal protein L14 contributes to the early assembly of 60S ribosomal subunits in Saccharomyces cerevisiae

Espinar Marchena, Francisco José; Rodríguez Galán, Olga; Fernández Fernández, José; Linnemann, Jan; Cruz Díaz, Jesús de la (Oxford University Press, 2018)
The contribution of most ribosomal proteins to ribo- some synthesis has been quite well analysed in Sac- charomyces ...
PhD Thesis
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Estudio del ensamblaje ribosómico en Saccharomyces Cerevisae.

Espinar Marchena, Francisco José; Cruz Díaz, Jesús de la (2017)
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Placeholder factors in ribosome biogenesis: please, pave my way

Espinar Marchena, Francisco José; Babiano González, Reyes; Cruz Díaz, Jesús de la (Shared Science Publishers, 2017)
The synthesis of cytoplasmic eukaryotic ribosomes is an extraordinarily energy-demanding cellular activity that occurs ...
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The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation

Gómez Herreros, Fernando; Margaritis, Thanasis; Rodríguez Galán, Olga; Pelechano, Vicent; Begley, Victoria Sarah; Millán Zambrano, Gonzalo; Morillo Huesca, Macarena; Muñoz Centeno, María de la Cruz; Pérez Ortín, José Enrique; Cruz Díaz, Jesús de la; Holstege, Frank C.P.; Chávez de Diego, Sebastián (Oxford University Press, 2017)
Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA ...
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The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits

Fernández Pevida, Antonio; Martín Villanueva, Sara; Murat, Guillaume; Lacombe, Thierry; Kressler, Dieter; Cruz Díaz, Jesús de la (Oxford University Press, 2016)
The archaea-/eukaryote-specific 40S-ribosomal-subunit protein S31 is expressed as an ubiquitin fusion protein in eukaryotes ...
Article
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The dedicated chaperone acl4 escorts ribosomal protein rpl4 to its nuclear pre-60s assembly site

Pillet, Benjamin; García Gómez, Juan José; Pausch, Patrick; Falquet, Laurent; Bange, Gert; Cruz Díaz, Jesús de la; Kressler, Dieter (Public Library of Science, 2015)
Ribosomes are the highly complex macromolecular assemblies dedicated to the synthesis of all cellular proteins from mRNA ...
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The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two β-propellers during the assembly of large ribosomal subunits in eukaryotes

Wegreck, Marcin; Rodríguez Galán, Olga; Cruz Díaz, Jesús de la; Bravo, Jerónimo (Oxford University Press, 2015)
Ribosome biogenesis is one of the most essential pathways in eukaryotes although it is still not fully characterized. Given ...
PhD Thesis
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Role of ubiquitin fusion ribosomal proteins in the synthesis and function of yeast ribosomes

Fernández Pevida, Antonio; Cruz Díaz, Jesús de la (2014)
Article
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Final pre-40s maturation depends on the functional integrity of the 60s subunit ribosomal protein l3

García Gómez, Juan José; Fernández Pevida, Antonio; Lebaron, Simon; Valle Rosado, Iván; Tollervey, David W.; Kressler, Dieter; Cruz Díaz, Jesús de la (Public Library of Science, 2014)
Ribosomal protein L3 is an evolutionarily conserved protein that participates in the assembly of early pre-60S particles. ...
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The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription

Mirón García, María Carmen; Garrido Godino, Ana Isabel; Martínez Fernández, Verónica; Fernández Pevida, Antonio; Cuevas Bermúdez, Abel; Martín Expósito, Manuel; Chávez de Diego, Sebastián; Cruz Díaz, Jesús de la; Navarro, Francisco (Oxford University Press, 2014)
Bud27, the yeast orthologue of human URI/RMP, is a member of the prefoldin-like family of ATPindependent molecular chaperones. ...
PhD Thesis
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Estudio funcional de proteínas ribosómicas durante la biogénesis de ribosomas en saccharomyces cerevisiae

Babiano González, Reyes; Cruz Díaz, Jesús de la (2013)
En el Capítulo I de esta tesis se muestran los resultados de la caracterización funcional de la proteína ribosómica L35, ...
PhD Thesis
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Análisis funcional de factores de actuación en trans y proteínas ribosómicas durante la síntesis de subunidades ribosómicas en Saccharomyces cerevisiae

García Gómez, Juan José; Cruz Díaz, Jesús de la (2013)
El estudio de la síntesis de los ribosomas eucariotas es un campo de investigación muy prolífico debido, sin duda, a la ...
Article
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Yeast Polypeptide Exit Tunnel Ribosomal Proteins L17, L35, and L37 are Necessary to Recruit Late-assembling Factors Required for 27SB Pre-rRNA Processing

Woolford, John L.; Babiano González, Reyes; Cruz Díaz, Jesús de la; Gamalinda, Michael; Jakovljevic, Jelena; Talkish, Jason (2013)
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Yeast ribosomal protein L7 and its homologue Rlp7 are simultaneously present at distinct sites on pre-60S ribosomal particles

Saveanu, Cosmin; Babiano González, Reyes; Badis, Gwenael; Díaz Quintana, Antonio Jesús; Cruz Díaz, Jesús de la; Doyen, Antonia; Fromont Racine, Micheline; Jacquier, Alain; Namame, Abdelkader; Saveanu, Cosmin (2013)
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Balanced production of ribosome components is required for proper G/S transition in saccharomyces cerevisiae

Gómez Herreros, Fernando; Rodríguez Galán, Olga; Morillo Huesca, Macarena; Maya, Douglas; Arista Romero, María; Cruz Díaz, Jesús de la; Chávez de Diego, Sebastián; Muñoz Centeno, María de la Cruz (American Society for Biochemistry and Molecular Biology Inc., 2013)
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Saccharomyces cerevisiae ribosomal protein L26 is not essential for ribosome assembly and function

Babiano González, Reyes; Gamalinda, Michael; Woolford, John L.; Cruz Díaz, Jesús de la (American Society for Microbiology, 2012)
Ribosomal proteins play important roles in ribosome biogenesis and function. Here, we study the evolutionarily conserved ...
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Yeast ribosomal protein L40 assembles late into precursor 60 S ribosomes and is required for their cytoplasmic maturation

Fernández Pevida, Antonio; Rodríguez Galán, Olga; Díaz Quintana, Antonio Jesús; Kressler, Dieter; Cruz Díaz, Jesús de la (Elsevier, 2012)
Background: The contribution of ribosomal proteins to ribosome assembly and function is often not well understood. Results: ...
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Nab2 functions in the metabolism of RNA driven by polymerases II and III

González Aguilera, Cristina; Tous, Cristina; Babiano González, Reyes; Cruz Díaz, Jesús de la; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Cell Biology, 2011)
Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One ...
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Dynamics of the putative RNA helicase spb4 during ribosome assembly insaccharomyces cerevisiae

García Gómez, Juan José; Lebaron, Simon; Froment, Carine; Monsarrat, Bernard; Henry, Yves; Cruz Díaz, Jesús de la (American Society for Microbiology, 2011)
Spb4 is a putative ATP-dependent RNA helicase that is required for proper processing of 27SB pre-rRNAs and therefore for ...
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Ribosomal protein L35 is required for 27SB pre-rRNA processing in Saccharomyces cerevisiae

Babiano González, Reyes; Cruz Díaz, Jesús de la (2010)
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Role and dynamics of the ribosomal protein p0 and its related trans-acting factor Mrt4 during ribosome assembly in Saccharomyces cerevisiae

Remacha, Miguel; Cruz Díaz, Jesús de la; García Gómez, Juan José; Ballesta, Juan Pedro G.; Francisco Velilla, Rosario; Francisco Velilla, Rosario (2009)
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The amino terminal domain from Mrt4 protein can functionally replace the RNA binding domain of the ribosomal P0 protein

Santos, C.; Abia, David; Ballesta, Juan Pedro G.; Cruz Díaz, Jesús de la; García Gómez, Juan José; Morreale, Antonio; Remacha, Miguel; Rodríguez Mateos, M. (2009)
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Functional analysis of saccharomyces cerevisiae ribosomal protein Rpl3p in ribosome synthesis

Valle Rosado, Iván; Kressler, Dieter; Cruz Díaz, Jesús de la (Oxford University Press, 2007)
Ribosome synthesis in eukaryotes requires a multitude oftrans-acting factors. These factors act at many steps as the ...
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Characterization of saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis

Rosado, Iván; Dez, Christophe; Lebaron, Simon; Caizergues-Ferrer, Michèle; Henry, Yves; Cruz Díaz, Jesús de la (American Society for Microbiology, 2007)
We report the characterization of the yeast Npa2p (Urb2p) protein, which is essential for 60S ribosomal subunit biogenesis. ...
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The essential WD-repeat protein Rsa4p is required for rRNA processing and intra-nuclear transport of 60S ribosomal subunits

Cruz Díaz, Jesús de la; Sanz Martínez, Eloisa; Remacha, Miguel (Oxford University Press, 2005)
We report the characterization of a novel factor, Rsa4p (Ycr072cp), which is essential for the synthesis of 60S ribosomal ...
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Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae

Valle Rosado, Iván; Cruz Díaz, Jesús de la (Cold Spring Harbor Laboratory Press, 2004)
Ribosome biogenesis requires > 100 nonribosomal proteins, which are associated with different preribosomal particles. The ...
Patent. Invention
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Proteína con actividad antifúngica

Rey Barrera, Manuel; Soler Castells, Andrés; Ait Lahsen, Hassane; Cruz Díaz, Jesús de la; Monte Vázquez, Enrique; Llobell González, Antonio (Oficina Española de Patentes y Marcas (OEPM), 2003)
Proteína con actividad antifúngica. Esta invención se refiere a una proteína con actividad antifúngica que posee, además, ...
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Increased sensitivity to protein synthesis inhibitors in cells lacking tmRNA

Cruz Díaz, Jesús de la; Vioque Peña, Agustín (Cold Spring Harbor Laboratory Press, 2001)
tmRNA (also known as SsrA or 10Sa RNA) is involved in a trans-translation reaction that contributes to the recycling of ...
Article
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An Antifungal Exo-alpha 1,3-Glucanase (AGN13.1) from the Biocontrol Fungus Trichoderma harzianum

Ait Lahsen, Hassane; Soler, Andrés; Rey, Manuel; Cruz Díaz, Jesús de la; Monte, Enrique; Llobell González, Antonio (American Society for Microbiology, 2001)
Trichoderma harzianum secretes α-1,3-glucanases when it is grown on polysaccharides, fungal cell walls, or autoclaved ...
Article
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Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae

Kressler, Dieter; Rojo, Manuel; Linder, Patrick; Cruz Díaz, Jesús de la (Oxford University Press, 1999)
Several mutants (spb1-spb7) have been previously identified as cold-sensitive extragenic suppressors of loss-of-function ...
Article
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Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae

Kressler, Dieter; Linder, Patrick; Cruz Díaz, Jesús de la (American Society for Microbiology, 1999)
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Spb4p, an essential putative RNA helicase, is required for a late step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae

Cruz Díaz, Jesús de la; Kressler, Dieter; Rojo, Manuel; Tollervey, David W.; Linder, Patrick (Cold Spring Harbor Laboratory Press, 1998)
Spb4p is a putative ATP-dependent RNA helicase that is required for synthesis of 60S ribosomal subunits. Polysome analyses ...
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Dbp6p is an essential putative ATP-dependent RNA helicase required for 60S-ribosomal-subunit assembly in Saccharomyces cerevisiae

Kressler, Dieter; Cruz Díaz, Jesús de la; Rojo, Manuel; Linder, Patrick (American Society for Microbiology, 1998)
A previously uncharacterizedSaccharomyces cerevisiaeopen reading frame, YNR038W, was analyzed in the context of the European ...
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Fal1p is an essential DEAD-box protein involved in 40S-ribosomal- subunit biogenesis in saccharomyces cerevisiae

Kressler, Dieter; Cruz Díaz, Jesús de la; Rojo, Manuel; Linder, Patrick (American Society for Microbiology, 1997)
A previously uncharacterizedSaccharomyces cerevisiaegene,FAL1, was found by sequence comparison as a homolog of the ...
Article
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Purification and characterization of an endo-beta-1,6-glucanase from Trichoderma harzianum that is related to its mycoparasitism

Cruz Díaz, Jesús de la; Pintor Toro, José Antonio; Benítez Fernández, Concepción Tahía; Llobell González, Antonio (American Society for Microbiology, 1995)
he enzymes from Trichoderma species that degrade fungal cell walls have been suggested to play an important role in ...
Article
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A novel endo-β-1,3-glucanase, BGN13.1, involved in the mycoparasitism of Trichoderma harzianum

Cruz Díaz, Jesús de la; Pintor Toro, José Antonio; Benítez Fernández, Concepción Tahía; Llobell González, Antonio; Romero González, Luis Carlos (American Society for Microbiology, 1995)
The mycoparasitic fungus Trichoderma harzianum CECT 2413 produces at least three extracellular β-1,3-glucanases. The most ...
PhD Thesis
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Purificación y caracterización de hidrolasas implicadas en el microparasitismo de Trichoderma harzianum

Cruz Díaz, Jesús de la; Benítez Fernández, Concepción Tahía; Llobell González, Antonio (1994)
Los hongos del genero Trichoderma son buenos agentes de control biológico. Entre los mecanismos que estos utilizan para ...