Perfil del autor: Cruz Díaz, Jesús de la
Datos institucionales
Nombre | Cruz Díaz, Jesús de la |
Departamento | Genética |
Área de conocimiento | Genética |
Categoría profesional | Catedrático de Universidad |
Correo electrónico | Solicitar |
Estadísticas
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Nº publicaciones
57
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Nº visitas
7932
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Nº descargas
13739
Publicaciones |
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Artículo
The Beak of Eukaryotic Ribosomes: Life, Work and Miracles
(MDPI, 2024)
Ribosomes are not totally globular machines. Instead, they comprise prominent structural protrusions and a myriad of ... |
Tesis Doctoral
Study of Pol5 protein from Saccharomyces cerevisiae and its human ortholog MYBBP1A in ribosome biogenesis
(2024)
Los ribosomas son los orgánulos celulares que llevan a cabo el llamado proceso de traducción, en el cual las proteínas se ... |
Tesis Doctoral
Molecular description of the role of protein synthesis in the cellular response to the treatment with the antitumoral drug Sorafenib in HCC lines
(2023)
El carcinoma hepatocellular (CHC) es reconocido como el principal cáncer primario de hígado y uno de los cánceres con mayor ... |
Tesis Doctoral
eL15 and eL22 proteins and their functional environments during ribosome assembly in Saccharomyces cerevisiae
(2023)
Ribosomes are ribonucleoprotein complexes in charge of protein translation. Translation is an essential process in all ... |
Artículo
The Terminal Extensions of Dbp7 Influence Growth and 60S Ribosomal Subunit Biogenesis in Saccharomyces cerevisiae
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
Ribosome synthesis is a complex process that involves a large set of protein trans-acting factors, among them DEx(D/H)-box ... |
Artículo
Ribosomal protein eL39 is important for maturation of the nascent polypeptide exit tunnel and proper protein folding during translation
(Oxford University Press, 2022)
During translation, nascent polypeptide chains travel from the peptidyl transferase center through the nascent polypeptide ... |
Artículo
Broad Transcriptomic Impact of Sorafenib and Its Relation to the Antitumoral Properties in Liver Cancer Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Hepatocellular carcinoma (HCC) is one of the most frequent and essentially incurable cancers in its advanced stages. The ... |
Artículo
The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation
(Taylor & Francis, 2022)
The small ribosomal subunit protein Rps15/uS19 is involved in early nucleolar ribosome biogenesis and subsequent nuclear ... |
Artículo
Ubiquitin and Ubiquitin-Like Proteins and Domains in Ribosome Production and Function: Chance or Necessity?
(Multidisciplinary Digital Publishing Institute (MDPI), 2021)
Ubiquitin is a small protein that is highly conserved throughout eukaryotes. It operates as a reversible post-translational ... |
Artículo
A functional connection between translation elongation and protein folding at the ribosome exit tunnel in Saccharomyces cerevisiae
(Oxford University Press, 2021)
Proteostasis needs to be tightly controlled to meet the cellular demand for correctly de novo folded proteins and to avoid ... |
Artículo
Association of snR190 snoRNA chaperone with early pre-60S particles is regulated by the RNA helicase Dbp7 in yeast
(Springer Nature, 2021)
Synthesis of eukaryotic ribosomes involves the assembly and maturation of precursor particles (pre-ribosomal particles) ... |
Tesis Doctoral
RNA Helicases in 60S Ribosomal Subunit Biogenesis in Saccharomyces cerevisiae
(2020)
The ribosomes are the cellular organelles responsible for translating messenger RNA (mRNA) to proteins. In eukaryotic ... |
Artículo
Prefoldin-like Bud27 influences the transcription of ribosomal components and ribosome biogenesis in Saccharomyces cerevisiae
(Cold Spring Harbor Laboratory Press, 2020)
Understanding the functional connection that occurs for the three nuclear RNA polymerases to synthesize ribosome components ... |
Artículo
Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells
(1421-9778, 2020)
Background/Aims: Orthotopic liver transplantation (OLT) is the recommended treatment for patients at early stages of ... |
Artículo
Overexpression of budding yeast protein phosphatase Ppz1 impairs translation
(Elsevier, 2020)
The Ser/Thr protein phosphatase Ppz1 from Saccharomyces cerevisiae is the best characterized member of a family of enzymes ... |
Artículo
The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes
(Oxford University Press, 2020)
The ribotoxin α-sarcin belongs to a family of ribonucleases that cleave the sarcin/ricin loop (SRL), a critical functional ... |
Tesis Doctoral |
Artículo
Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae
(Cold Spring Harbor Laboratory Press, 2019)
In Saccharomyces cerevisiae, more than 250 trans-acting factors are involved in the maturation of 40S and 60S ribosomal ... |
Artículo
The Ubiquitin Moiety of Ubi1 Is Required for Productive Expression of Ribosomal Protein eL40 in Saccharomyces cerevisiae
(MDPI, 2019)
Ubiquitin is a highly conserved small eukaryotic protein. It is generated by proteolytic cleavage of precursor proteins ... |
Artículo
Ribosomal protein L14 contributes to the early assembly of 60S ribosomal subunits in Saccharomyces cerevisiae
(Oxford University Press, 2018)
The contribution of most ribosomal proteins to ribo- some synthesis has been quite well analysed in Sac- charomyces ... |
Artículo
Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells
(Wiley-Blackwell, 2018)
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular ... |
Tesis Doctoral |
Artículo
The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation
(Oxford University Press, 2017)
Ribosome assembly requires the concerted expression of hundreds of genes, which are transcribed by all three nuclear RNA ... |
Artículo
Placeholder factors in ribosome biogenesis: please, pave my way
(Shared Science Publishers, 2017)
The synthesis of cytoplasmic eukaryotic ribosomes is an extraordinarily energy-demanding cellular activity that occurs ... |
Artículo
The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits
(Oxford University Press, 2016)
The archaea-/eukaryote-specific 40S-ribosomal-subunit protein S31 is expressed as an ubiquitin fusion protein in eukaryotes ... |
Artículo
The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two β-propellers during the assembly of large ribosomal subunits in eukaryotes
(Oxford University Press, 2015)
Ribosome biogenesis is one of the most essential pathways in eukaryotes although it is still not fully characterized. Given ... |
Artículo
The dedicated chaperone acl4 escorts ribosomal protein rpl4 to its nuclear pre-60s assembly site
(Public Library of Science, 2015)
Ribosomes are the highly complex macromolecular assemblies dedicated to the synthesis of all cellular proteins from mRNA ... |
Artículo
Final pre-40s maturation depends on the functional integrity of the 60s subunit ribosomal protein l3
(Public Library of Science, 2014)
Ribosomal protein L3 is an evolutionarily conserved protein that participates in the assembly of early pre-60S particles. ... |
Tesis Doctoral |
Artículo
The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription
(Oxford University Press, 2014)
Bud27, the yeast orthologue of human URI/RMP, is a member of the prefoldin-like family of ATPindependent molecular chaperones. ... |
Tesis Doctoral
Estudio funcional de proteínas ribosómicas durante la biogénesis de ribosomas en saccharomyces cerevisiae
(2013)
En el Capítulo I de esta tesis se muestran los resultados de la caracterización funcional de la proteína ribosómica L35, ... |
Tesis Doctoral
Análisis funcional de factores de actuación en trans y proteínas ribosómicas durante la síntesis de subunidades ribosómicas en Saccharomyces cerevisiae
(2013)
El estudio de la síntesis de los ribosomas eucariotas es un campo de investigación muy prolífico debido, sin duda, a la ... |
Artículo |
Artículo
Balanced production of ribosome components is required for proper G/S transition in saccharomyces cerevisiae
(American Society for Biochemistry and Molecular Biology Inc., 2013)
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Artículo |
Artículo
Yeast ribosomal protein L40 assembles late into precursor 60 S ribosomes and is required for their cytoplasmic maturation
(Elsevier, 2012)
Background: The contribution of ribosomal proteins to ribosome assembly and function is often not well understood. Results: ... |
Artículo
Saccharomyces cerevisiae ribosomal protein L26 is not essential for ribosome assembly and function
(American Society for Microbiology, 2012)
Ribosomal proteins play important roles in ribosome biogenesis and function. Here, we study the evolutionarily conserved ... |
Artículo
Nab2 functions in the metabolism of RNA driven by polymerases II and III
(American Society for Cell Biology, 2011)
Gene expression in eukaryotes is an essential process that includes transcription, RNA processing, and export. One ... |
Artículo
Dynamics of the putative RNA helicase spb4 during ribosome assembly insaccharomyces cerevisiae
(American Society for Microbiology, 2011)
Spb4 is a putative ATP-dependent RNA helicase that is required for proper processing of 27SB pre-rRNAs and therefore for ... |
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Artículo |
Artículo |
Artículo
Functional analysis of saccharomyces cerevisiae ribosomal protein Rpl3p in ribosome synthesis
(Oxford University Press, 2007)
Ribosome synthesis in eukaryotes requires a multitude oftrans-acting factors. These factors act at many steps as the ... |
Artículo
Characterization of saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis
(American Society for Microbiology, 2007)
We report the characterization of the yeast Npa2p (Urb2p) protein, which is essential for 60S ribosomal subunit biogenesis. ... |
Artículo
The essential WD-repeat protein Rsa4p is required for rRNA processing and intra-nuclear transport of 60S ribosomal subunits
(Oxford University Press, 2005)
We report the characterization of a novel factor, Rsa4p (Ycr072cp), which is essential for the synthesis of 60S ribosomal ... |
Artículo
Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae
(Cold Spring Harbor Laboratory Press, 2004)
Ribosome biogenesis requires > 100 nonribosomal proteins, which are associated with different preribosomal particles. The ... |
Patente. Invención
Proteína con actividad antifúngica
(Oficina Española de Patentes y Marcas (OEPM), 2003)
Proteína con actividad antifúngica. Esta invención se refiere a una proteína con actividad antifúngica que posee, además, ... |
Artículo
Increased sensitivity to protein synthesis inhibitors in cells lacking tmRNA
(Cold Spring Harbor Laboratory Press, 2001)
tmRNA (also known as SsrA or 10Sa RNA) is involved in a trans-translation reaction that contributes to the recycling of ... |
Artículo
An Antifungal Exo-alpha 1,3-Glucanase (AGN13.1) from the Biocontrol Fungus Trichoderma harzianum
(American Society for Microbiology, 2001)
Trichoderma harzianum secretes α-1,3-glucanases when it is grown on polysaccharides, fungal cell walls, or autoclaved ... |
Artículo
Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae
(Oxford University Press, 1999)
Several mutants (spb1-spb7) have been previously identified as cold-sensitive extragenic suppressors of loss-of-function ... |
Artículo
Protein trans-acting factors involved in ribosome biogenesis in Saccharomyces cerevisiae
(American Society for Microbiology, 1999)
|
Artículo
Dbp6p is an essential putative ATP-dependent RNA helicase required for 60S-ribosomal-subunit assembly in Saccharomyces cerevisiae
(American Society for Microbiology, 1998)
A previously uncharacterizedSaccharomyces cerevisiaeopen reading frame, YNR038W, was analyzed in the context of the European ... |
Artículo
Spb4p, an essential putative RNA helicase, is required for a late step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae
(Cold Spring Harbor Laboratory Press, 1998)
Spb4p is a putative ATP-dependent RNA helicase that is required for synthesis of 60S ribosomal subunits. Polysome analyses ... |
Artículo
Fal1p is an essential DEAD-box protein involved in 40S-ribosomal- subunit biogenesis in saccharomyces cerevisiae
(American Society for Microbiology, 1997)
A previously uncharacterizedSaccharomyces cerevisiaegene,FAL1, was found by sequence comparison as a homolog of the ... |
Artículo
Purification and characterization of an endo-beta-1,6-glucanase from Trichoderma harzianum that is related to its mycoparasitism
(American Society for Microbiology, 1995)
he enzymes from Trichoderma species that degrade fungal cell walls have been suggested to play an important role in ... |
Artículo
A novel endo-β-1,3-glucanase, BGN13.1, involved in the mycoparasitism of Trichoderma harzianum
(American Society for Microbiology, 1995)
The mycoparasitic fungus Trichoderma harzianum CECT 2413 produces at least three extracellular β-1,3-glucanases. The most ... |
Tesis Doctoral
Purificación y caracterización de hidrolasas implicadas en el microparasitismo de Trichoderma harzianum
(1994)
Los hongos del genero Trichoderma son buenos agentes de control biológico. Entre los mecanismos que estos utilizan para ... |