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dc.creatorChacin, Erikaes
dc.creatorBansal, Priyankaes
dc.creatorReusswig, Karl-Uwees
dc.creatorDíaz Santín, Luis M.es
dc.creatorOrtega Moreno, Pedroes
dc.creatorVizjak, Petraes
dc.creatorGómez González, Belénes
dc.creatorMüller-Planitz, Felixes
dc.creatorAguilera López, Andréses
dc.creatorPfander, Borises
dc.creatorCheung, Alan C. M.es
dc.creatorKurat, Christoph F.es
dc.date.accessioned2021-09-17T15:16:36Z
dc.date.available2021-09-17T15:16:36Z
dc.date.issued2021
dc.identifier.citationChacin, E., Bansal, P., Reusswig, K., Díaz Santín, L.M., Ortega Moreno, P., Vizjak, P.,...,Kurat, C.F. (2021). A CDK-regulated chromatin segregase promoting chromosome replication. Nature Communications, 12 (1), 5224.
dc.identifier.issn2041-1723es
dc.identifier.urihttps://hdl.handle.net/11441/125968
dc.description.abstractThe replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can result in genome instability, which is a major driver of cancer. Yet how chromatin is made accessible during eukaryotic DNA synthesis is poorly understood. Here, we report the characterization of a chromatin remodeling enzyme—Yta7—entirely distinct from classical SNF2-ATPase family remodelers. Yta7 is a AAA+ -ATPase that assembles into ~1 MDa hexameric complexes capable of segregating histones from DNA. The Yta7 chromatin segregase promotes chromosome replication both in vivo and in vitro. Biochemical reconstitution experiments using purified proteins revealed that the enzymatic activity of Yta7 is regulated by S phase-forms of Cyclin-Dependent Kinase (S-CDK). S-CDK phosphorylation stimulates ATP hydrolysis by Yta7, promoting nucleosome disassembly and chromatin replication. Our results present a mechanism for how cells orchestrate chromatin dynamics in co-ordination with the cell cycle machinery to promote genome duplication during S phase.es
dc.description.sponsorshipGerman Research Foundation ID 213249687, SFB 1064, MU 3613/3-1, PF794/5-1es
dc.formatapplication/pdfes
dc.format.extent12 p.es
dc.language.isoenges
dc.publisherSpringer Naturees
dc.relation.ispartofNature Communications, 12 (1), 5224.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleA CDK-regulated chromatin segregase promoting chromosome replicationes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Genéticaes
dc.relation.projectIDID 213249687es
dc.relation.projectIDSFB 1064es
dc.relation.projectIDMU 3613/3-1es
dc.relation.projectIDPF794/5-1es
dc.relation.publisherversionhttps://doi.org/10.1038/s41467-021-25424-7es
dc.identifier.doi10.1038/s41467-021-25424-7es
dc.journaltitleNature Communicationses
dc.publication.volumen12es
dc.publication.issue1es
dc.publication.initialPage5224es

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