dc.creator | Cruz-Chamorro, Ivan | es |
dc.creator | Álvarez-Sánchez, Nuria | es |
dc.creator | Santos-Sánchez, Guillermo | es |
dc.creator | Lardone, Patricia Judith | es |
dc.creator | Bejarano, Ignacio | es |
dc.creator | Guerrero, Juan Miguel | es |
dc.creator | Carrillo Vico, Antonio | es |
dc.date.accessioned | 2021-08-31T09:49:17Z | |
dc.date.available | 2021-08-31T09:49:17Z | |
dc.date.issued | 2020-06-04 | |
dc.identifier.citation | Cruz-Chamorro, I., Álvarez-Sánchez, N., Santos-Sánchez, G., Lardone, P.J., Bejarano, I., Guerrero, J.M. y Carrillo Vico, A. (2020). Immunomodulatory and Antioxidant Properties of Wheat Gluten Protein Hydrolysates in Human Peripheral Blood Mononuclear Cells. Nutrients, 12 (6), art.n.1673. https://doi.org/10.3390/nu12061673. | |
dc.identifier.issn | 2072-6643 (electrónica) | es |
dc.identifier.uri | https://hdl.handle.net/11441/125234 | |
dc.description.abstract | Peptides from several plant food proteins not only maintain the nutritional values of the
original protein and decrease the environmental impact of animal agriculture, but also exert biological
activities with significant health-beneficial effects. Wheat is the most important food grain source
in the world. However, negative attention on wheat-based products has arose due to the role of
gluten in celiac disease. A controlled enzymatic hydrolysis could reduce the antigenicity of wheat
gluten protein hydrolysates (WGPHs). Therefore, the aims of the present study were to evaluate
the effects of the in vitro administration of Alcalase-generated WGPHs on the immunological and
antioxidant responses of human peripheral blood mononuclear cells (PBMCs) from 39 healthy subjects.
WGPH treatment reduced cell proliferation and the production of the Type 1 T helper (Th1) and
Th17 pro-inflammatory cytokines IFN-γ and IL-17, respectively. WPGHs also improved the cellular
anti-inflammatory microenvironment, increasing Th2/Th1 and Th2/Th17 balances. Additionally,
WGPHs improved global antioxidant capacity, increased levels of the reduced form of glutathione
and reduced nitric oxide production. These findings, not previously reported, highlight the beneficial
capacity of these vegetable protein hydrolysates, which might represent an effective alternative in
functional food generation. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad (AGL2012-40247-C02-01 and AGL2012-40247-C02-02) | es |
dc.description.sponsorship | Andalusian Government Ministry of Health (PC-0111-2016-0111) | es |
dc.description.sponsorship | PAIDI Program from the Andalusian Government (CTS160) | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad (AGL2012-40247-C02-02) | es |
dc.description.sponsorship | Ministerio de Educación, Cultura y Deporte (FPU13/01210) | es |
dc.description.sponsorship | Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (RD06/0013/0001 and RD12/0043/0012) | es |
dc.description.sponsorship | Ministerio de Educación, Cultura y Deporte (FPU16/02339) | es |
dc.description.sponsorship | VI Program of Inner Initiative for Research and Transfer of University of Seville (VI PPIT-US) | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Nutrients, 12 (6), art.n.1673. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Wheat gluten protein hydrolysates | es |
dc.subject | Bioactive peptides | es |
dc.subject | Pro-inflammatory cytokines | es |
dc.subject | Oxidative stress | es |
dc.subject | Antioxidant capacity | es |
dc.subject | Glutathione | es |
dc.subject | Peripheral blood mononuclear cells | es |
dc.title | Immunomodulatory and Antioxidant Properties of Wheat Gluten Protein Hydrolysates in Human Peripheral Blood Mononuclear Cells | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.projectID | AGL2012-40247-C02-01 | es |
dc.relation.projectID | AGL2012-40247-C02-02 | es |
dc.relation.projectID | PC-0111-2016-0111 | es |
dc.relation.projectID | CTS160 | es |
dc.relation.projectID | AGL2012-40247-C02-02 | es |
dc.relation.projectID | FPU13/01210 | es |
dc.relation.projectID | RD06/0013/0001 | es |
dc.relation.projectID | RD12/0043/0012 | es |
dc.relation.projectID | FPU16/02339 | es |
dc.relation.projectID | VI PPIT-US | es |
dc.relation.publisherversion | https://www.mdpi.com/2072-6643/12/6/1673 | es |
dc.identifier.doi | 10.3390/nu12061673 | es |
dc.journaltitle | Nutrients | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | art.n.1673 | es |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina | |