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Mostrando ítems 41-50 de 59
Artículo
Yra1-bound RNA–DNA hybrids cause orientation-independent transcription– replication collisions and telomere instability
(Cold Spring Harbor Laboratory Press, 2018)
R loops are an important source of genome instability, largely due to their negative impact on replication progression. Yra1/ALY is an abundant RNA-binding factor conserved from yeast to humans and required for mRNA export, ...
Artículo
Artículo
Dna-rna hybrids at dsbs interfere with repair by homologous recombination
(eLife Sciences Publications, 2021)
DNA double-strand breaks (DSBs) are the most harmful DNA lesions and their repair is crucial for cell viability and genome integrity. The readout of DSB repair may depend on whether DSBs occur at transcribed versus ...
Artículo
The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
(Elsevier, 2011)
Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. Examining checkpoint-dependent mechanisms controlling fork stability, we find that fork reversal and ...
Artículo
The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage
(Public Library of Science, 2017)
RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence of RNase H enzymes, RNA-DNA hybrids accumulate, resulting in replication stress, DNA damage and ...
Artículo
A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs
(Elsevier B.V., 2019)
Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by double-strand breaks (DSBs). Inaccuracies in this process can drive aneuploidy and developmental defects, ...
Artículo
Histone Mutants Separate R Loop Formation from Genome Instability Induction
(Elsevier, 2017)
R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms for this are unknown. Here we identified yeast histone H3 and H4 mutations that facilitate R ...
Artículo
Epigenetic features of human telomeres
(Oxford University Press, 2018)
Although subtelomeric regions in humans are heterochromatic, the epigenetic nature of human telomeres remains controversial. This controversy might have been influenced by the confounding effect of subtelomeric regions and ...
Artículo
WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.
(Nature Research, 2022)
Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR) causes genomic instability. Genomic instability occurs in Wiskott-Aldrich syndrome (WAS), a primary immunodeficiency disorder, yet the ...
Artículo
Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination
(Oxford University Press, 2013)
While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of double-strand break (DSB) repair is exerted at several steps, the key step is DNA end resection, which in ...