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Mostrando ítems 51-57 de 57
Artículo
Roles of Extracellular Vesicles Associated Non-coding RNAs in Diabetes Mellitus
(Frontiers Media SA, 2022)
Extracellular vesicles (EVs), especially exosomes (50 to 150 nm), have been shown to play important roles in a wide range of physiological and pathological processes, including metabolic diseases such as Diabetes Mellitus ...
Artículo
Enzyme-Responsive Zr-Based Metal-Organic Frameworks for Controlled Drug Delivery: Taking Advantage of Clickable PEG-Phosphate Ligands
(American Chemical Society, 2023)
We report for the first time the controlled drug release from a nanoscale Zr-based metal-organic framework (MOF), UiO-66, in the presence of the enzyme alkaline phosphatase (ALP). This unprecedented reactivity was possible ...
Artículo
FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine
(Springer Nature, 2022)
Fanconi anemia (FA) is a rare hereditary disorder caused by mutations in any one of the FANC genes. FA cells are mainly characterized by extreme hypersensitivity to interstrand crosslink (ICL) agents. Additionally, the FA ...
Artículo
Mitochondrial Factors in the Cell Nucleus
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
The origin of eukaryotic organisms involved the integration of mitochondria into the ancestor cell, with a massive gene transfer from the original proteobacterium to the host nucleus. Thus, mitochondrial performance relies ...
Artículo
Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
(Oxford University Press, 2023-03-29)
Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are ...
Artículo
UBE2D3 Facilitates NHEJ by Orchestrating ATM Signalling through Multi-level Control of RNF168
(Springer Nature, 2024)
Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation and ubiquitination representing key elements. How these events are coordinated to achieve ...
Artículo
Prevalence of root canal treatments among diabetic patients: systematic review and meta-analysis
(Mdpi, 2023)
(1) Apical periodontitis (AP) is the inflammatory response of the periapical tissue to bacterial antigens and toxins arriving from inside the root canal after pulp necrosis. To control AP, it is necessary to interrupt ...