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Mostrando ítems 1-10 de 18
Artículo
Systematic evaluation of plasma signaling cascades by functional proteomics approaches SARS-CoV-2 infection as model
(Wiley, 2022-09-28)
Purpose Acute phase reactants (APRs) play a critical role in inflammation. The difference in their physiological functions or the different dynamic ranges of these proteins in plasma makes it difficult to detect them ...
Artículo
Homocysteine levels, genetic background, and cognitive impairment in Parkinson’s disease
(Springer Nature, 2023)
Background: Hyperhomocysteinemia is considered an independent risk factor for cognitive impairment. Objective: To study the correlation between homocysteine levels and cognitive impairment in patients with PD. Methods: ...
Artículo
Extracellular Vesicles as Biomarkers in Liver Disease
(MDPI, 2022-12-19)
Extracellular vesicles (EVs) are membrane-derived vesicles released by a variety of cell types, including hepatocytes, hepatic stellate cells, and immune cells in normal and pathological conditions. Depending on their ...
Artículo
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
(OXFORD UNIV PRESS, 2022)
Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease worldwide, accounting for a high liver-related mortality and morbidity with extensive multi organ involvement. This entity has ...
Artículo
Assessing the Impact of SARS-CoV-2 Lineages and Mutations on Patient Survival
(MDPI, 2022)
Objectives: More than two years into the COVID-19 pandemic, SARS-CoV-2 still remains a global public health problem. Successive waves of infection have produced new SARS-CoV-2 variants with new mutations for which the ...
Artículo
Sofosbuvir improves HCV-induced insulin resistance by blocking IRS1 degradation
(WILEY, 2021-01-12)
In the present study, we have demonstrated that sofos buvir (SOF) treatment improves systemic insulin resis tance in hepatitis C virus (HCV)-patients, and, for the first time, revealed which molecular mechanisms are ...
Artículo
Similar CD4/CD8 Ratio Recovery After Initiation of Dolutegravir Plus Lamivudine Versus Dolutegravir or Bictegravir-Based Three-Drug Regimens in Naive Adults With HIV
(FRONTIERS MEDIA SA, 2022)
The initiation of antiretroviral treatment based on a 2-drug regimen (2DR) with dolutegravir plus lamivudine has demonstrated non-inferior efficacy than dolutegravir-based three-drug regimens (3DR). We aimed to assess ...
Artículo
Orthohepevirus C infection as an emerging cause of acute hepatitis in Spain: First report in Europe
(Elsevier, 2022-02-12)
Background & Aim Hepatitis E virus (HEV) was considered the only member of the Hepeviridae family with zoonotic potential. Nevertheless, this consideration has been reassessed owing to several reported cases of acute and ...
Artículo
Mutations, Genes, and Phenotypes Related to Movement Disorders and Ataxias
(MDPI, 2022-12-08)
Our clinical series comprises 124 patients with movement disorders (MDs) and/or ataxia with cerebellar atrophy (CA), many of them showing signs of neurodegeneration with brain iron accumulation (NBIA). Ten NBIA genes are ...
Artículo
Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged people
(Journal of clinical investigation, 2022)
The immune factors associated with impaired SARS-CoV-2 vaccine response in elderly people are mostly unknown. We studied individuals older than 60 and younger than 60 years, who had been vaccinated with SARS-CoV-2 ...