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Mostrando ítems 41-50 de 53
Artículo
Predictors of global non-motor symptoms burden progression in Parkinson’s disease. Results from the COPPADIS cohort at 2-year follow-up
(MDPI, 2021-06-30)
Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson’s disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after ...
Artículo
Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study
(MDPI, 2022)
Objective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson’s disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients ...
Artículo
Non‑motor symptom burden in patients with parkinson’s disease with impulse control disorders and compulsive behaviours: results from the coppADiS cohort
(Springer Nature, 2020)
The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ...
Artículo
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
(NATURE PUBLISHING GROUP, 2021)
ARTICLE Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk ...
Artículo
NR4A2 Mutations Can Cause Intellectual Disability and Language Impairment With Persistent Dystonia-Parkinsonism
(2021)
The NR4A2/NURR1 gene (MIM*601828) has recently been associated with autosomal-dominant early-onset dystonia-parkinsonism with intellectual disability.1 NR4A2 codifies for a nuclear transcription factor and is expressed ...
Artículo
Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients
(Nature Research, 2021-09-07)
A prodromal phase of Parkinson’s disease (PD) may precede motor manifestations by decades. PD patients’ siblings are at higher risk for PD, but the prevalence and distribution of prodromal symptoms are unknown. The study ...
Artículo
Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage
(Nature Research, 2021-04-06)
Knowledge of genomic features specific to the human lineage may provide insights into brain-related diseases. We leverage high-depth whole genome sequencing data to generate a combined annotation identifying regions ...
Artículo
MNCD: A New Tool for Classifying Parkinson’s Disease in Daily Clinical Practice
(MDPI, 2022)
Background and objective: Parkinson’s disease (PD) is a clinically heterogeneous disorder in which the symptoms and prognosis can be very different among patients. We propose a new simple classification to identify key ...
Artículo
Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project
(MDPI, 2021-07-31)
Abstract: Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common neurodegenerative disease worldwide. In Spain, it affects around 120.000–150.000 individuals, and its ...
Artículo
Consenso de expertos españoles sobre el uso de la safinamida en la enfermedad de Parkinson
(Science Direct, 2021)
La safinamida es un nuevo fármaco para el tratamiento de pacientes con enfermedad de Parkinson (EP) con fluctuaciones como tratamiento complementario a levodopa. Dado que por el momento aún no existen estudios de fase IV ...