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Artículo
Peripheral inflammatory immune response differs among sporadic and familial Parkinson’s disease
(Springer, 2023)
Peripheral inflammatory immune responses are thought to play a major role in the pathogenesis of Parkinson’s disease (PD). The neutrophil-to-lymphocyte ratio (NLR), a biomarker of systemic inflammation, has been reported ...
Artículo
Embracing monogenic Parkinson's disease: the MJFF global genetic PD cohort
(Wiley, 2023)
ABSTRACT: Background: As gene-targeted therapies are increasingly being developed for Parkinson’s disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a ...
Artículo
Homocysteine levels, genetic background, and cognitive impairment in Parkinson’s disease
(Springer Nature, 2023)
Background: Hyperhomocysteinemia is considered an independent risk factor for cognitive impairment. Objective: To study the correlation between homocysteine levels and cognitive impairment in patients with PD. Methods: ...
Artículo
Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome
(Nature Publishing Group, 2023)
Tourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a year. It is highly polygenic in nature with both rare and common previously associated variants. ...
Artículo
Mendelian randomisation confirms the role of Y-chromosome loss in Alzheimer’s disease aetiopathogenesis in men
(MDPI, 2023)
Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY ...
Artículo
Sex differences in motor and non-motor symptoms among Spanish patients with Parkinson’s disease
(MDPI, 2023)
Background and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the ...
Artículo
Falls predict acute hospitalization in Parkinson's disease
(IOS Press, 2023)
Background: There is a need for identifying risk factors for hospitalization in Parkinson’s disease (PD) and also interventions to reduce acute hospital admission. Objective: To analyze the frequency, causes, and predictors ...