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Browsing Artículos (Fisiología Médica y Biofísica) by Author "Macías, David"
Now showing items 1-7 of 7
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Article
2-hydroxyglutarate metabolism is altered in an in vivo model of LPS induced endotoxemia
Fitzpatrick, S. F.; Lambden, S.; Macías, David; Puthucheary, Z.; Pietsch, S.; Mendil, L. (Frontiers Media, 2020)The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the ...
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Article
An Indocyanine Green-Based Nanoprobe for In Vivo Detection of Cellular Senescence
Baker, Andrew G.; Hartono, Muhamad; Ou, Hui-Ling; Popov, Andrea Bistrovic; Brown, Emma L.; Joseph, James; Golinska, Monika; Gonzalez-Gualda, Estela; Macías, David; Fruk, Ljiljana (Wiley, 2024)Abstract: There is an urgent need to improve conventional cancer-treatments by preventing detrimental side effects, cancer ...
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Article
Carotid body oxygen sensing and adaptation to hipoxia
López Barneo, José; Macías, David; Platero-Luengo, Aida; Ortega Sáenz, Patricia; Pardal Redondo, Ricardo (Springer, 2015-09)The carotid body (CB) is the principal arterial chemoreceptor that mediates the hyperventilatory response to hypoxia. Our ...
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Article
Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors
Lambden, Simon; Cowburn, Andrew S.; Macías, David; Garrud, Tessa A. C.; Krause, Bernardo J.; Giussani, Dino A.; Summers, Charlotte; Johnson, Randall S. (SpringerOpen, 2021-06-11)Background The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular ...
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Article
Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity
González-Gualda, E.; Páez-Ribes, M.; Lozano-Torres, B.; Macías, David; Wilson III, J. R.; González-López, C.; Ou, H. L. (Wiley Open Access, 2020)Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ...
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Article
HIF-2a is essential for carotid body development and function
Macías, David; Cowburn, Andrew S.; Torres Torrelo, Hortensia; Ortega Sáenz, Patricia; López Barneo, José; Johnson, Randall S (eLife Sciences Publications, 2018-04-19)Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations ...
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Article
Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension
Macías, David; Moore, Stephen; Crosby, Alexi; Southwood, Mark; Du, Xinlin; Tan, Huiling; Cowburn, Andrew S. (European Respiratory Society, 2021-03-04)Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart ...