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- Fisiología Médica y Biofísica
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Listar Artículos (Fisiología Médica y Biofísica) por autor "Gao Chen, Lin"
Mostrando ítems 1-9 de 9
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Artículo
Age-mediated transcriptomic changes in adult mouse substantia nigra
Gao Chen, Lin; Hidalgo-Figueroa, María; Escudero Cuadrado, Luis María; Díaz Martín, Juan; López Barneo, José; Pascual Bravo, Alberto (2013)Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson’s disease ...
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Gene expression analyses reveal metabolic specifications in acute O-2-sensing chemoreceptor cells
Gao Chen, Lin; Bonilla Henao, Victoria; García-Flores, Paula; Arias-Mayenco, Ignacio; Ortega Sáenz, Patricia; López Barneo, José (Wiley, 2017-09)Acute O2sensing is a fundamental property of cells in the peripheral chemoreceptors,e.g. glomus cells in the carotid body ...
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Glucose sensing by carotid body glomus cells: potential implications in disease
Gao Chen, Lin; Ortega Sáenz, Patricia; García Fernández, María; González Rodríguez, Patricia; Caballero Eraso, Candela; López Barneo, José (Frontiers Media, 2014-10-15)The carotid body (CB) is a key chemoreceptor organ in which glomus cells sense changes in blood O2, CO2, and pH levels. ...
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Molecular mechanisms of acute oxygen sensing by arterial chemoreceptor cells. Role of Hif2α
Ortega Sáenz, Patricia; Moreno Domínguez, Alejandro; Gao Chen, Lin; López Barneo, José (Frontiers Research Foundation, 2020)Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical ...
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Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors
Cabello Rivera, Daniel; Ortega Sáenz, Patricia; Gao Chen, Lin; Muñoz Cabello, Ana María; Bonilla-Henao, Victoria; Schumacker, Paul T.; López Barneo, José (National Academy of Sciences, 2022)Acute oxygen (O2) sensing is essential for adaptation of organisms to hypoxic environments or medical conditions with ...
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Redox signaling in acute oxygen sensing
Gao Chen, Lin; González Rodríguez, Patricia; Ortega Sáenz, Patricia; López Barneo, José (Elsevier, 2017-04-26)Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the ...
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Reduced expression of mitochondrial complex I subunit Ndufs2 does not impact healthspan in mice
McElroy, Gregory S.; Chakrabarty, Ram P.; D’Alessandro, Karis B.; Vasan, Karthik; Tan, Jerica; Stoolman, Joshua S.; Gao Chen, Lin; López Barneo, José; Navdeep S. (Nature Publishing Group, 2022)Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial electron transport chain complex I. ...
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Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice
Jiménez Gómez, Blanca; Ortega Sáenz, Patricia; Gao Chen, Lin; González Rodríguez, Patricia; García-Flores, Paula; Chandel, Navdeep; López Barneo, José (NATURE PUBLISHING GROUP, 2023)The hypoxic ventilatory response (HVR) is a life-saving reflex, triggered by the activation of chemoreceptor glomus cells ...
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Using redox-sensitive fluorescent probes to record real-time reactive oxygen species production in cells from mouse carotid body slices
Gao Chen, Lin; Arias-Mayenco, Ignacio; Ortega Sáenz, Patricia; López Barneo, José (Cell Press, 2021)Reactive oxygen species (ROS) are important signaling molecules for physiologic processes such as acute response to ...