Listar Artículos (Fisiología Médica y Biofísica) por título
Mostrando ítems 281-300 de 332
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STIM and Orai1 Variants in Store-Operated Calcium Entry
(Frontiers Research Foundation, 2016-01-13)Store-operated Ca2+ entry (SOCE) is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx ...
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Store-operated calcium entry in breast cancer cells is insensitive to Orai1 and STIM1 N-linked glycosylation
(MDPI, 2022-12-29)N-linked glycosylation is a post-translational modification that affects protein function, structure, and interaction ...
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Structure/Function Analysis of Ca2 + Binding to the C2A Domain of Synaptotagmin 1
(2002)Synaptotagmin 1, a Ca2+ sensor for fast synaptic vesicle exocytosis, contains two C2 domains that form Ca2+ -dependent ...
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Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation
(American Association for the Advancement of Science, 2022)Effective T cell-mediated immune responses require the proper allocation of metabolic resources to sustain growth, ...
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Sushi domain-containing protein 4 controls synaptic plasticity and motor learning
(2021)Fine control of protein stoichiometry at synapses underlies brain function and plasticity. How proteostasis is controlled ...
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Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains
(Frontiers Media S.A., 2022)The appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the ...
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Synaptic defects in spinal muscular atrophy animal models
(Wiley, 2011)Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss ...
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Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy
(OXFORD UNIV PRESS, 2016)Spinal muscular atrophy (SMA) is the most frequent genetic cause of infant mortality. The disease is characterized ...
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Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions
(AMER PHYSIOLOGICAL SOC, 2015)Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions. ...
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Targeting Aquaporin Function: Potent Inhibition of Aquaglyceroporin-3 by a Gold-Based Compound
(Public Library of Science, 2012-05-18)Aquaporins (AQPs) are membrane channels that conduct water and small solutes such as glycerol and are involved in many ...
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Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension
(European Respiratory Society, 2021-03-04)Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart ...
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Ten simple rules for aspiring graduate students
(Public Library of Science, 2021-08-19)Several supervillains have higher degrees—why don’t you? There can be a variety of reasons for wanting to go to grad school ...
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The Active and Periactive Zone Organization and the Functional Properties of Small and Large Synapses
(2016-05-24)The arrival of an action potential (AP) at a synaptic terminal elicits highly synchronized quanta release. Repetitive APs ...
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The carotid body, a neurogenic niche in the adult peripheral nervous system
(Univ pisa, 2010)We have described a new population of adult neural stem cells residing in the carotid body, a chemoreceptor organ in the ...
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The carotid body: a physiologically relevant germinal niche in the adult peripheral nervous system
(Springer, 2018-11-29)Oxygen constitutes a vital element for the survival of every single cell in multicellular aerobic organisms like mammals. ...
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The Childhood-Onset Neurodegeneration with Cerebellar Atrophy (CONDCA) Disease Caused by AGTPBP1 Gene Mutations: The Purkinje Cell Degeneration Mouse as an Animal Model for the Study of this Human Disease
(MDPI, 2021-09-04)Recent reports have identified rare, biallelic damaging variants of the AGTPBP1 gene that cause a novel and documented ...
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The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells
(Frontiers Media, 2018-03-21)Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. ...
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The effects of dendritic cell-based vaccines in the tumor microenvironment Impact on myeloid-derived suppressor cells
(Frontiers Media, 2022-11-15)Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished ...
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