Browsing Artículos (Fisiología Médica y Biofísica) by Title
Now showing items 270-289 of 332
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SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models
(MDPI, 2022-10-20)muscular atrophy (SMA). SMN forms the core of a protein complex localized at the cytoplasm and nuclear gems and that ...
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SMN Requirement for Synaptic Vesicle, Active Zone and Microtubule Postnatal Organization in Motor Nerve Terminals
(2011-10-12)Low levels of the Survival Motor Neuron (SMN) protein produce Spinal Muscular Atrophy (SMA), a severe monogenetic disease ...
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Smn-Deficiency Increases the Intrinsic Excitability of Motoneurons
(2017-09-05)During development, motoneurons experience significant changes in their size and in the number and strength of connections ...
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Sodium and Calcium Currents in Dispersed Mammalian Septal Neurons
(1991)Voltage-gated Na+ and Ca2+ conductances of freshly dissociated septal neurons were studied in the whole-cell configuration ...
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SOS GEFs in health and disease
(Elsevier, 2020)SOS1 and SOS2 are the most universal and widely expressed family of guanine exchange factors (GEFs) capable or activating ...
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SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology
(MDPI, 2021-06-21)The SOS family of Ras-GEFs encompasses two highly homologous and widely expressed members, SOS1 and SOS2. Despite their ...
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Spanish Cell Therapy Network (TerCel): 15 years of successful collaborative translational research
(Elsevier, 2020)In the current article we summarize the 15-year experience of the Spanish Cell Therapy Network (TerCel), a successful ...
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Spike protein of SARS-CoV-2 Omicron variant An in-silico study evaluating spike interactions and immune evasion
(Frontiers Media, 2022-11-29)Background: The fundamentals of the infectivity and immune evasion of the SARS-CoV-2 Omicron variant are not yet fully ...
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SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
(Nature Portfolio, 2020)Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for ...
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State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
(Cell Press, 2019-02-26)Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the ...
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Statistical Agnostic Mapping: A framework in neuroimaging based on concentration inequalities
(Elsevier, 2021-02)In the 1970s a novel branch of statistics emerged focusing its effort on the selection of a function for the pattern ...
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STIM and Orai1 Variants in Store-Operated Calcium Entry
(Frontiers Research Foundation, 2016-01-13)Store-operated Ca2+ entry (SOCE) is an ubiquitous mechanism for Ca2+ entry in eukaryotic cells. This route for Ca2+ influx ...
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Store-operated calcium entry in breast cancer cells is insensitive to Orai1 and STIM1 N-linked glycosylation
(MDPI, 2022-12-29)N-linked glycosylation is a post-translational modification that affects protein function, structure, and interaction ...
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Structure/Function Analysis of Ca2 + Binding to the C2A Domain of Synaptotagmin 1
(2002)Synaptotagmin 1, a Ca2+ sensor for fast synaptic vesicle exocytosis, contains two C2 domains that form Ca2+ -dependent ...
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Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation
(American Association for the Advancement of Science, 2022)Effective T cell-mediated immune responses require the proper allocation of metabolic resources to sustain growth, ...
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Sushi domain-containing protein 4 controls synaptic plasticity and motor learning
(2021)Fine control of protein stoichiometry at synapses underlies brain function and plasticity. How proteostasis is controlled ...
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Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains
(Frontiers Media S.A., 2022)The appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the ...
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Synaptic defects in spinal muscular atrophy animal models
(Wiley, 2011)Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss ...
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Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy
(OXFORD UNIV PRESS, 2016)Spinal muscular atrophy (SMA) is the most frequent genetic cause of infant mortality. The disease is characterized ...
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Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions
(AMER PHYSIOLOGICAL SOC, 2015)Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions. ...