Artículo
State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
Autor/es | García-Junco Clemente, Pablo
![]() ![]() ![]() ![]() ![]() ![]() Tring, Elaine Ringach, Dario L. Trachtenberg, Joshua T. |
Departamento | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica |
Fecha de publicación | 2019-02-26 |
Fecha de depósito | 2020-09-30 |
Publicado en |
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Resumen | Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is
reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory
input from the ... Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition. We find that fast-spiking, parvalbuminexpressing inhibitory neurons, which exert state-dependent control of network gain and spike patterns, cluster into two stable and functionally distinct subnetworks that are differentially engaged by ascending neuromodulation. One group is excited as a function of increased arousal state; this excitation is driven in part by the increase in cortical norepinephrine that occurs when the locus coeruleus is active. A second group is suppressed during movement when acetylcholine is released into the cortex via projections from the nucleus basalis. These data establish the presence of functionally independent subnetworks of Parvalbumin (PV) cells in the upper layers of the neocortex that are differentially engaged by the ascending reticular activating system. |
Identificador del proyecto | R01 EY023871
![]() R01 EY018322 ![]() EB022915 ![]() P12-CTS-2232 ![]() RYC-2016-19906 ![]() |
Cita | García-Junco Clemente, P., Tring, E., Ringach, D.L. y Trachtenberg, J.T. (2019). State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex. Cell Reports, 26 (9) |
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cell reports.pdf | 1.849Mb | ![]() | Ver/ | State-Dependent Subnetworks |